Abstract:The LTβR plays an essential role in the initiation of immune responses to intracellular pathogens. In mice, the LTβR is crucial for surviving acute toxoplasmosis, however, up to now a functional analysis is largely incomplete. Here, we demonstrate that the LTβR is a key regulator required for the intricate balance of adaptive immune responses. T. gondii infected LTβR−/− mice show globally altered IFNγ regulation, reduced IFNγ-controlled host effector molecule expression, impaired T cell functionality and an ab… Show more
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