Lymphotoxin ? An immunologic hormone with anticarcinogenic and antitumor activity

A cytotoxic substance (CTS-51) produced by human buffy coat cultures stimulated by Staphylococcal enterotoxin B: Further characterizations and combined action with interferon.

“…Lymphokine preparations are generally known to contain mixtures of several biological active molecules, each of which may have individual immunological activities in vivo (Evans 1982). The CTS-51 preparation used in this study was isolated from the culture supernatant of the human bully coat cultures stimulated by staphlococcal enterotoxin B (SE B) during the mass production process of the immune interferon and interleukin-2, as previously described (Hirai et al 1985).…”

“…The susceptibility of Daudi lymphoma cells to the antiproliferative action of HuIFN-a (Le) was further potentiated by treating the cells with CTS-51 for 16 hr. On the other hand, the CTS-51 activity which was revealed to be prescribed by its concentration in the medium, was not potentiated at 39°C when compared to that at 37°C in contrast to HuIFN-a (Le) action, and was reduced according to the increase of the fetal calf serum concentration in the medium.cytokine ; interferon ; cytotoxicity It is generally known that lymphocytes or monocytes, when activated by the antigen-or mitogen-stimulation, release a mixture of several biologically active soluble factors, with various molecular sizes, which are usually called lymphokines or monokines, generally called "cytokines" as a whole (Evans 1982). It has been argued, from several quarters (Evans 1982;Ransom and Evans 1982; …”

“…cytokine ; interferon ; cytotoxicity It is generally known that lymphocytes or monocytes, when activated by the antigen-or mitogen-stimulation, release a mixture of several biologically active soluble factors, with various molecular sizes, which are usually called lymphokines or monokines, generally called "cytokines" as a whole (Evans 1982). It has been argued, from several quarters (Evans 1982;Ransom and Evans 1982; …”

“…Some of these factors, such as, for example, interferons and interleukin-2, are revealed to have a property to potentiate the cytotoxic activities of several cellular immunological systems, such as, for example, natural killer cell system or MLC derived cell mediated cytotoxicity system (Heron et al 1976(Heron et al , 1979Marx 1983). On the other hand, several other cytokines have been reported to have a property directly cytotoxic to the target cells in vitro, which include lymphotoxins (Evans 1982), tumor necrosis factors (williamson et al 1983), natural killer cytotoxic factors (Bonavida et al 1982) and immune interferons (Rubin and Gupta 1980).…”

Control of the carcinogenic potential of 99mTechnetium by the immunologic hormone lymphotoxin

“…The immune system can suppress and/or inhibit the growth of carcinogen-induced preneoplastic cells [1,22]. Both cellular (macrophages and natural killer cells) and molecular (immunologic hormones, lymphokines) immune mediators have been identified in controlling the development of cancer [9,21]. The natural immunologic hormones may provide new immunopharmacologic agents for the prevention of cancer [9,12,27].…”