Lymphoscintigraphic Demonstration of Chyle Leak After Kidney Transplantation and Gamma Camera Detection of Radioactivity in Chylous Aspirate

Oh, Jin Kyoung; Yoon, Hye Eun; Chung, Yun Kyung

doi:10.1097/rlu.0000000000000482

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…Chyluria 14is secondary to a fistula between the paraaortic lymph nodes and the kidney, with backflow toward the renal lymph nodes and extravasation in the collecting system. It is associated with filariasis, cancer, abdominal surgery (including live-donor nephrectomy, renal transplantation, and oncologic procedures (17)(18)(19)), or lymphangiitis (20). Forty-one patients with chyluria were imaged using 99m Tc-dextran, and only the early appearance of kidney or pelvis activity was indicative of lymphourinary fistula (20).…”

Section: Discussionmentioning

confidence: 99%

Lymphoscintigraphy of Chylous Anomalies: Chylothorax, Chyloperitoneum, Chyluria, and Lymphangiomatosis—15-Year Experience in a Pediatric Setting and Review of the Literature

Turpin

Lambert

2018

J. Nucl. Med. Technol.

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In the pediatric setting, lymphoscintigraphy is used mostly for the evaluation of lymphedema. Only a few cases of chylous anomalies and lymphatic malformations imaged with lymphoscintigraphy have been reported in the literature. The aim of this study was to review the use of lymphoscintigraphy in those pathologies. All lymphoscintigraphy studies performed for chylous anomalies between 2001 and 2017 in our hospital were retrospectively reviewed. The results were correlated to clinical and radiologic findings. Lymphoscintigraphy consisted of sequential imaging after injection of 3.7-9.25 MBq (100-250 μCi) ofTc-filtered sulfur colloid at the level of the feet or hands. Twenty-five studies were performed on 21 patients. Fourteen studies were obtained for the evaluation of chylothorax. Eleven were performed for chyloperitoneum, chyluria, chylopericardium, exudative enteropathy, or lymphangiomatosis. Ten studies were positive for lymphatic leakage, and 1 had uncertain results. After correlation with radiologic findings and follow-up, there were 7 true-negative and 5 false-negative results (previousGa-interfering activity in 1, injection in only the hands in 3, and a low-fat diet in 1). One study became positive after injection in the feet, and another became positive after a switch to a high-fat diet. Lymphoscintigraphy is a useful tool for imaging lymphatic anomalies in children. Suggestions to optimize results include placing the patient on a high-fat diet, withholding octreotide, injecting the 4 extremities, and imaging with SPECT/CT.

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Section: Discussionmentioning

confidence: 99%

Lymphoscintigraphy of Chylous Anomalies: Chylothorax, Chyloperitoneum, Chyluria, and Lymphangiomatosis—15-Year Experience in a Pediatric Setting and Review of the Literature

Turpin

Lambert

2018

J. Nucl. Med. Technol.

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“…[ 9 – 16 ] For many years, lymphoscintigraphy has been widely considered as the first-line imaging to confirm the diagnosis of lymphedema and to visualize the functional state of the lymphatic system. [ 15 , 17 – 23 ]…”

Section: Introductionmentioning

confidence: 99%

“…Lymphatic system imaging in nuclear medicine directly reflects the function of lymphatic drainage [9–16] . For many years, lymphoscintigraphy has been widely considered as the first-line imaging to confirm the diagnosis of lymphedema and to visualize the functional state of the lymphatic system [15,17–23] …”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11][12][13][14][15][16] For many years, lymphoscintigraphy has been widely considered as the first-line imaging to confirm the diagnosis of lymphedema and to visualize the functional state of the lymphatic system. [15,[17][18][19][20][21][22][23] The purpose of this study was to investigate the relationship between iliolumbar LNs, inguinal LNs, and unilateral pelvic cancer-related lymphedema by retrospective analysis of 99m Tcantimony sulfide colloid (ASC) lymphoscintigraphy data.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between the drainage function of inguinal lymph nodes and unilateral pelvic cancer-related lymphedema

et al. 2021

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The aim of this study was to investigate the relationship between iliolumbar lymph nodes (LNs), inguinal LNs, and unilateral pelvic cancer-related lymphedema by retrospective analysis of lymphoscintigraphy data. Ninety-six patients (3 men and 93 women; mean age, 53.3 ± 11.3 years) with pelvic cancer-related lymphedema were enrolled in this retrospective study. Lymphoscintigraphy was performed at 1 hour and 4 to 6 hours after injection. The visualization of inguinal LNs and iliolumbar LNs were recorded. According to statistical analysis, the display of inguinal LNs in lymphoscintigraphy has a significant negative correlation with ipsilateral lower limb lymphedema ( P < .01, r = –0.561). However, there is no correlation between the show of iliolumbar LNs and ipsilateral lower extremity lymphedema ( P = .056, r = –0.138). When lymphoscintigraphy was performed at 1 hour after injection, there were 13 out of 96 patients without inguinal LNs revealed on imaging, but at 4 to 6 hours after injection, inguinal LNs were seen in lymphoscintigraphy. The drainage function of inguinal LNs has a significant negative correlation with ipsilateral pelvic cancer-related lymphedema. Treatment dedicated to restoring the drainage function of LNs in the inguinal region may effectively relieve lymphedema. The image acquisition at 4 to 6 hours after injection is necessary for significant additional information.

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“…Lymphoscintigraphy using 99m Tc-SC is inexpensive with a safety profile and has long been used in the evaluation of pathologies involving lymphatic drainage. 1 – 7 However, 99m Tc-SC scintigraphy also has several disadvantages, including minimal absorption from the injection site and slow transport from the injection site after subcutaneous administration. 8 Evans blue dye is used for the determination of plasma volume and map for the drainage basins of sentinel node localization.…”

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confidence: 99%

Potential Applications of Using 68Ga–Evans Blue PET/CT in the Evaluation of Lymphatic Disorder

Zhang

et al. 2016

Clinical Nuclear Medicine

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PurposePotentials of 68Ga-NEB as a PET tracer in the evaluation of a variety of lymphatic drainage disorders were analyzed.Methods68Ga-NEB was injected subcutaneously, and the PET/CT images were acquired in 13 patients with different suspected lymphatic drainage abnormality. The 68Ga-NEB PET/CT findings were compared with 99mTc-SC lymphoscintigraphy.Results68Ga-NEB activity could be clearly observed in the lymphatic route on the PET/CT images from all the patients. In 5 (38.5%) of 13 patients tested, 68Ga-NEB PET/CT provided more information than the 99mTc-SC lymphoscintigraphy.Conclusions68Ga-NEB PET/CT can be used as an alternative of 99mTc-SC lymphoscintigraphy in the evaluation of lymphatic disorders, which enables fast results and might be more accurate than the conventional 99mTc-SC lymphoscintigraphy.

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Lymphoscintigraphic Demonstration of Chyle Leak After Kidney Transplantation and Gamma Camera Detection of Radioactivity in Chylous Aspirate

Cited by 3 publications

References 6 publications

Lymphoscintigraphy of Chylous Anomalies: Chylothorax, Chyloperitoneum, Chyluria, and Lymphangiomatosis—15-Year Experience in a Pediatric Setting and Review of the Literature

Lymphoscintigraphy of Chylous Anomalies: Chylothorax, Chyloperitoneum, Chyluria, and Lymphangiomatosis—15-Year Experience in a Pediatric Setting and Review of the Literature

The relationship between the drainage function of inguinal lymph nodes and unilateral pelvic cancer-related lymphedema

Potential Applications of Using 68Ga–Evans Blue PET/CT in the Evaluation of Lymphatic Disorder

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