Lymphoproliferative disorders and motor neuron disease

Gordon, Paul H.; Rowland, Lewis P.; Younger, David S.; Sherman, William H.; Hays, Arthur P.; Louis, Elan D.; Lange, Dale J.; Trojaborg, W.; Lovelace, Robert E.; Murphy, Peregrine L.; Latov, N.

doi:10.1212/wnl.48.6.1671

Cited by 114 publications

(44 citation statements)

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“…Only rare improvement occurs with immunosuppressive treatment. 43,94 Based on these studies, it has been suggested that patients with motor neuron disease and cerebrospinal fluid protein levels greater than 75 mg/dl, oligoclonal bands, or monoclonal serum proteins should undergo evaluation for lymphoproliferative disease. 153 Most amyotrophic lateral sclerosis centers have not reported a similar experience in patients with amyotrophic lateral sclerosis and these may be chance associations.…”

Section: Clinical Presentationsmentioning

confidence: 99%

Lymphoma and peripheral neuropathy: A clinical review

2004

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Lymphoma occasionally affects the peripheral nervous system. When it does, the diagnosis can be elusive since many patients present without known lymphoma. Most peripheral nerve complications are due to non-Hodgkin's lymphoma (NHL), which infiltrates nerves causing axonal damage. This disorder can affect nerve roots and cranial nerves, often associated with lymphomatous meningitis. NHL may also infiltrate peripheral nerves and cause plexopathy, mononeuropathy, or generalized neuropathy. These neuropathies may resemble an asymmetric mononeuropathy multiplex or a generalized disorder such as chronic inflammatory demyelinating polyradiculoneuropathy. When NHL infiltrates diffusely, the term neurolymphomatosis is used. Hodgkin's lymphoma (HL), by contrast, rarely infiltrates nerves. More often, HL causes immunological disorders of the peripheral nervous system such as inflammatory plexopathy or Guillain-Barré syndrome. Other rare lymphomas such as intravascular lymphoma and Waldenstrom's macroglobulinemia can also affect peripheral nerves in specific ways. In addition, other malignant and nonmalignant lymphoproliferative disorders enter into the differential diagnosis of lymphomatous neuropathy. This review discusses the multiple peripheral nerve presentations of lymphoma from the clinician's point of view and provides a guide to the evaluation and diagnosis of these uncommon, challenging disorders.

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Section: Clinical Presentationsmentioning

confidence: 99%

Lymphoma and peripheral neuropathy: A clinical review

2004

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“…Heavy metals, especially aluminium, have also been regarded as possible causes of SALS [11] as have such organic toxins as pesticides, herbicides, formaldehyde, glutamatergic agonists and cyanotoxins [12][13][14][15]. SALS has also been associated with cellular proliferative diseases, especially haemopoetic ones [16], and with electrical shocks [17], excessive physical exercise [18,19] and dietary habits [20]. However, the evidence available has not allowed any of these possible factors to be sustained as a cause of SALS, and there is thus a need to look elsewhere.…”

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confidence: 99%

Is amyotrophic lateral sclerosis a primary astrocytic disease?

Sica¹

2012

Medical Hypotheses

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“…(ALS) [1][2][3][4][5][6][7], but several studies, dating back to the 1940s, have reported the co-occurrence of cancer and MND [8- [17,211 suggests that MND may in certain cases be a paraneoplastic syndrome. We report 14 patients with cancer and M N D who could be divided into three distinct groups.…”

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confidence: 99%

Motor neuron syndromes in cancer patients

Forsyth

Dalmau

Graus

et al. 1997

Annals of Neurology

170

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Previous reports indicate that motor neuron disease (MND) may rarely be associated with systemic cancer. We have encountered 14 patients with MND and cancer who formed three distinct groups. Group 1: Three patients developed a rapidly progressive MND, less prominent symptoms of involvement of other areas of the nervous system, and anti-Hu antibodies. Group 2: Five women developed signs of upper motor neuron (UMN) disease, initially resembling primary lateral sclerosis (PLS), and breast cancer. In 4, symptoms of UMN occurred within 3 months of cancer diagnosis or tumor recurrence. They had no metastases or spinal cord compression. Serum anti-neuronal antibodies were negative. Three patients are alive (follow-up of 156, 15, and 12 months), and 2 remain without lower motor neuron signs. Group 3: Six patients developed MND resembling amyotrophic lateral sclerosis between 47 months before and 48 months after their cancer diagnosis. In group 1, the MND associated with the anti-Hu antibody is unequivocally paraneoplastic. In group 2, the proximate onset of MND with the diagnosis of cancer or its recurrence, its pure or long-lasting UMN signs, and its association with breast cancer, suggest that the disorder may be paraneoplastic. Although for most cancer patients who develop MND the occurrence of both disorders is probably coincidental, in some patients with MND a careful search for an underlying cancer is warranted (ie, patients in groups 1 and 2).

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Lymphoproliferative disorders and motor neuron disease

Cited by 114 publications

References 0 publications

Lymphoma and peripheral neuropathy: A clinical review

Lymphoma and peripheral neuropathy: A clinical review

Is amyotrophic lateral sclerosis a primary astrocytic disease?

Motor neuron syndromes in cancer patients

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