Lymphoplasmacytic plaque in children: Case report and literature review

Abstract

We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm. K E Y W O R D Slymphoplasmacytic plaque, pseudolymphoma

A 13‐year‐old boy with a red‐brown plaque on his leg

“…Lymphoproliferative conditions of plasma cells may be ruled out with kappa‐lambda light chain detection for monoclonality 6 . In several prior case series and case reports, authors have argued for an infectious workup to rule out fungal, mycobacterial, leishmania, and spirochete infections with histologic stains, PCR, serology, or culture 2,6 . However, no instances of an associated infectious agent have been reported with published cases of lymphoplasmocytic plaques thus far.…”

“…This condition classically occurs on the pretibial area but has since been found on the upper extremities, trunk, and buttocks. [1][2][3] Morphologically, patients present with a solitary erythematous or red-brown plaque that may sometimes occur as a result of coalescing red-brown papules. Diagnosis has been reported during childhood or adolescence.…”

“…Lymphoplasmacytic plaque of childhood, also known as pretibial lymphoplasmocytic plaque, is a rare, recently described clinicopathologic entity characterized by a clinically stable cutaneous plaque in conjunction with the histologic finding of a dense dermal lymphoplasmacytic infiltrate in the absence of identifiable infectious triggers or systemic disease. This condition classically occurs on the pretibial area but has since been found on the upper extremities, trunk, and buttocks 1‐3 . Morphologically, patients present with a solitary erythematous or red‐brown plaque that may sometimes occur as a result of coalescing red‐brown papules.…”

“…The clinical course of lymphoplasmocytic plaque of childhood is generally considered benign and without systemic involvement. While spontaneous resolution has not been reported, two published pediatric cases have shown clinical stability over 10 years 2,6,7 . Still, insufficient knowledge on the eventual natural history of these lesions in adulthood was found.…”

“…While spontaneous resolution has not been reported, two published pediatric cases have shown clinical stability over 10 years. 2,6,7 Still, insufficient knowledge on the eventual natural history of these lesions in adulthood was found. Topical and intralesional steroids may provide partial improvement, but recurrence or persistence is more typical.…”