Abstract:To maintain the size of T cell pools throughout life, homeostatic mechanisms regulate both survival and proliferation through IL-7 and TCR signaling. IL-7 (through lymphopenia-induced proliferation/LIP) can also mediate expansion of autoreactive clones leading to the onset of autoimmune disease or enhance effector function against tumors and viruses. In the present study, we hypothesized that in a setting of chronic inflammatory environment, such as HIV infection, LIP could contribute to the immune activation … Show more
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