Lymphopenia during the COVID-19 infection: What it shows and what can be learned

Tavakolpour, Soheil; Rakhshandehroo, Taha; Wei, Enoch P.; Rashidian, Mohammad

doi:10.1016/j.imlet.2020.06.013

Cited by 286 publications

(265 citation statements)

References 12 publications

Supporting

Mentioning

240

Contrasting

Unclassified

Order By: Relevance

“…The presence of lymphopenia can be related to the inflammatory cytokine storm. Decreased T cell counts, particularly CD8+, has been observed in severe cases [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Chest CT Severity Scores and the Clinical Parameters of Adult Patients with COVID-19 Pneumonia

Saeed

Gaba

Shah

et al. 2021

Radiology Research and Practice

118

119

View full text Add to dashboard Cite

Purpose. Our aim is to correlate the clinical condition of patients with COVID-19 infection with the 25-point CT severity score by Chang et al. (devised for assessment of ARDS in patients with SARS in 2005). Materials and Methods. Data of consecutive symptomatic patients who were suspected to have COVID-19 infection and presented to our hospital were collected from March to April 2020. All patients underwent two consecutive RT-PCR tests and had a noncontrast HRCT scan done at presentation. From the original cohort of 1062 patients, 160 patients were excluded leaving a total number of 902 patients. Results. The mean age was 44.2 ± 11.9 years (85.3% males, 14.7% females). CT severity score was found to be positively correlated with lymphopenia, increased serum CRP, d-dimer, and ferritin levels ( p < 0.0001 ). The oxygen requirements and length of hospital stay were increasing with the increase in scan severity. Conclusion. The 25-point CT severity score correlates well with the COVID-19 clinical severity. Our data suggest that chest CT scoring system can aid in predicting COVID-19 disease outcome and significantly correlates with lab tests and oxygen requirements.

show abstract

“…The presence of lymphopenia can be related to the inflammatory cytokine storm. Decreased T cell counts, particularly CD8+, has been observed in severe cases [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Chest CT Severity Scores and the Clinical Parameters of Adult Patients with COVID-19 Pneumonia

Saeed

Gaba

Shah

et al. 2021

Radiology Research and Practice

118

119

View full text Add to dashboard Cite

show abstract

“…This correlates with the risk of severe and fatal COVID-19 disease, which is higher in males than in females and also increases with age 49 . Several evidences also reveal the occurrence of significant lymphopenia in a large proportion of COVID-19 patients [2][3][4]49,62 . Recently, a ferroptosis signature was reported in a case report of COVID-19 patient (48-year-old, male), showing 4-HNE, a reactive breakdown product of the lipid peroxides or oxidized phosphatidylcholine was positive in myocardial tissue staining and in the proximal tubules of acute kidney injury, with decreased lymphocytes in the blood 63 .…”

Section: A Hypothesis On the Association Between Covid-19 And Ferroptmentioning

confidence: 99%

SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

Yang

Lai

2020

Cell Death Discov.

View full text Add to dashboard Cite

Since the outbreak of the new coronavirus in 2019 (SARS-CoV-2), many studies have been performed to better understand the basic mechanisms and clinical features of the disease. However, uncertainties of the underlying mechanisms of multiple organ involvement remain. A substantial proportion of severe coronavirus disease 2019 (COVID-19) patients have lymphopenia, low serum iron levels, and multiple organ involvement. Several therapeutic agents have been used for different stages of the disease, but the treatment for severe disease is still suboptimal. Understanding the mechanism of programmed cell death in COVID-19 may lead to better therapeutic strategies for these patients. On the basis of observations of basic science studies and clinical researches on COVID-19, we hypothesize that ferroptosis, a novel programmed cell death, may be an important cause of multiple organ involvement in COVID-19 and it might serve as a new treatment target. In spite of the existing findings on the involvement of ferroptosis in SARS-CoV-2 infection, there is no reported study to uncover how does ferroptosis acts in SARS-CoV-2 infection yet. Uncovering the role of ferroptosis in SARS-CoV-2 infection is essential to develop new treatment strategies for COVID-19. Intracellular cell iron depletion or new generation of ferroptosis inhibitors might be potential drug candidates for COVID-19. We hope this hypothesis may launch a new wave of studies to uncover the association of ferroptosis and SARS-CoV-2 infection in vitro and in vivo.

show abstract

“…All of these factors are associated with immune cell recruitment that can amplify the acute and sustained inflammatory state in the lungs. Interestingly, other studies have observed an important lymphopenia characterized by a drastic decrease of CD4 + and CD8 + cells in patients with severe forms of COVID-19 (Tavakolpour et al, 2020). This was often associated with decreased circulating levels of IFN-γ, which is known to have antiviral properties by stimulating the recruitment of lymphocytes.…”

Section: Most Common Cytokines Identified In Severe Forms Of Covid-19mentioning

confidence: 98%

Nutraceutical Targeting of Inflammation-Modulating microRNAs in Severe Forms of COVID-19: A Novel Approach to Prevent the Cytokine Storm

et al. 2020

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19) pandemic has become the number one health problem worldwide. As of August 2020, it has affected more than 18 million humans and caused over 700,000 deaths worldwide. COVID-19 is an infectious disease that can lead to severe acute respiratory syndrome. Under certain circumstances, the viral infection leads to excessive and uncontrolled inflammatory response, which is associated with the massive release of inflammatory cytokines in pulmonary alveolar structures. This phenomenon has been referred to as the “cytokine storm,” and it is closely linked to lung injury, acute respiratory syndrome and mortality. Unfortunately, there is currently no vaccine available to prevent the infection, and no effective treatment is available to reduce the mortality associated with the severe form of the disease. The cytokine storm associate with COVID-19 shows similarities with those observed in other pathologies such as sepsis, acute respiratory distress syndrome, acute lung injury and other viral infection including severe cases of influenza. However, the specific mechanisms that cause and modulate the cytokine storm in the different conditions remain to be determined. micro-RNAs are important regulators of gene expression, including key inflammatory cytokines involved in the massive recruitment of immune cells to the lungs such as IL1β, IL6, and TNFα. In recent years, it has been shown that nutraceutical agents can modulate the expression of miRs involved in the regulation of cytokines in various inflammatory diseases. Here we review the potential role of inflammatory-regulating-miRs in the cytokine storm associated with COVID-19, and propose that nutraceutical agents may represent a supportive therapeutic approach to modulate dysregulated miRs in this condition, providing benefits in severe respiratory diseases.

show abstract

Lymphopenia during the COVID-19 infection: What it shows and what can be learned

Cited by 286 publications

References 12 publications

Correlation between Chest CT Severity Scores and the Clinical Parameters of Adult Patients with COVID-19 Pneumonia

Correlation between Chest CT Severity Scores and the Clinical Parameters of Adult Patients with COVID-19 Pneumonia

SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

Nutraceutical Targeting of Inflammation-Modulating microRNAs in Severe Forms of COVID-19: A Novel Approach to Prevent the Cytokine Storm

Contact Info

Product

Resources

About