Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature

Abstract

Lymphomatoid papulosis (LyP) is a cutaneous CD30-positive T-cell lymphoproliferative disorder that occurs primarily in adults and presents with crops of papules that become necrotic and spontaneously regress. It is classified according to the histopathologic findings; currently recognized subtypes include A, B, C, D, and E. LyP is uncommon in children. Herein we describe a child with an unusual clinical presentation of LyP type D and review the literature of reported cases in children.

Lymphomatoid papulosis types D and E: a multicentre series of the French Cutaneous Lymphomas Study Group

“…Since the first description of LyP D in 2010, < 50 cases have been described, in patients with an age range of 5–91 years 9,12–19 . In our series, the clinical presentation was similar to classic LyP types.…”

“…11 Since the first description of LyP D in 2010, < 50 cases have been described, in patients with an age range of 5-91 years. 9,[12][13][14][15][16][17][18][19] In our series, the clinical presentation was similar to classic LyP types. The lesions seem to exist on a spectrum ranging from small erythematous scaly PLC-like papules to lesions developing central erosion, and finally to large papulonodules with central necrosis.…”

Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature review

“…Lymphomatoid papulosis (LyP) is a rare condition within primary cutaneous CD30 + lymphoproliferative disorders [ 1 – 3 ]. LyP is clinically characterized by papules, small nodules with varying degrees of central hemorrhage and necrotic ulceration, and histologically by a dermal infiltrate of atypical CD30 + large T-lymphoid cells [ 1 – 4 ].…”

“…LyP is clinically characterized by papules, small nodules with varying degrees of central hemorrhage and necrotic ulceration, and histologically by a dermal infiltrate of atypical CD30 + large T-lymphoid cells [ 1 – 4 ]. Usually, the lesions regress after several weeks or months with topical or systemic therapy, with an overall favorable prognosis [ 3 ]. However, LyP is characterized by a chronic course, and it has been rarely associated with progression to secondary lymphoma (mycosis fungoides, anaplastic large cell lymphoma, or Hodgkin’s lymphoma) [ 5 ].…”

“…LyP occurs primarily in adults in the third and fourth decades of life and is unusual in children [ 3 ]. The most common subtype in pediatric age is type A, and LyP type D has been reported in only 7 pediatric patients younger than 18 years of age [ 1 – 4 , 6 – 8 ].…”