“…11 It has been reported but not confirmed that subtypes A and D of LyP have been associated with a lower risk for developing a second malignancy while subtypes B and C present a higher risk. 2 Although the histopathological subtypes have not been included in the article of Melchers et al to rule out or confirm these findings, a manuscript of the same group including a large part of these same patients showed that there are no prognostic differences between the different histological subtypes, considering in particular A and C subtypes. 11 Other prognostic markers that has been suggested as useful to predict the development of a second lymphoid neoplasm such as frequent relapses of LyP lesions, involvement of the face, an older age, the expression of fascin by CD30+ large cells, high blood levels of soluble CD30, CD25, interleukin (IL) 6, and IL-8 and a detectable T-cell clone 3 have not been highlighted by this study, and the risk factors for developing a second HM remains pending.…”