Lymphomatoid Granulomatosis of the Skin and Lung

McNiff, Jennifer M.; Cooper, Dennis; Howe, Greg; Crotty, Paul; Tallini, Giovanni; Crouch, Jill; Eisen, Richard N.

doi:10.1001/archderm.1996.03890360054010

Cited by 61 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other neoplastic lymphocytes display a strong angiocentric distribution pattern. and presumably are being directed by a different set of trafficking signals (23). Another group of neoplastic lymphocytes remain confined largely to within vascular lumina, the so-called intravascular lymphomas (24).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous infiltrate of chronic lymphocytic leukemia and relationship to primary cutaneous epithelial neoplasms

Smoller¹,

Warnke²

1998

J Cutan Pathol

View full text Add to dashboard Cite

Chronic lymphocytic leukemia involves the skin in a small percentage of patients and may portend an ominous prognosis in some patients. We report a series of eight biopsies from seven different patients in which the cutaneous leukemic infiltrate was confined exclusively to the region immediately surrounding primary epithelial neoplasms including squamous cell carcinoma (6), basal cell carcinoma (1) and actinic keratosis (1). The malignant lymphocytes appear to constitute a host response to these neoplasms and do not appear to suggest a rapid downhill course for these patients. These observations serve to 1) suggest a new pattern of cutaneous involvement by leukemic cells and 2) offer some insights into potential cellular trafficking patterns of these neoplastic cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Cutaneous infiltrate of chronic lymphocytic leukemia and relationship to primary cutaneous epithelial neoplasms

Smoller¹,

Warnke²

1998

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…[9][10][11][12][13][14][15][16] Neoplastic conditions should also be considered. In the past, these processes may have been referred to as lethal [17][18][19][20][21][22][23][24][25][26] The confirmation of these latter processes requires adequate tissue for histopathologic examination. In addition to routine microscopy, a battery of T-cell, B-cell, and NK-cell immunoperoxidase stains is required, as well as in situ hybridization to look for the presence of EBV.…”

Section: Discussionmentioning

confidence: 99%

Destructive facial T‐cell lymphoma: the difficulty in diagnosis of pyoderma‐like processes

et al. 2004

View full text Add to dashboard Cite

A 48‐year‐old woman presented with extensive facial ulceration of 1 year in duration. Based on the combination of the clinical appearance and a “nondiagnostic” biopsy taken elsewhere, the patient was started on oral prednisone at a dose of 40 mg/day, with a working diagnosis of pyoderma gangrenosum. According to the patient, the ulceration worsened over the 2 months whilst on prednisone and pain control was a major issue, controlled for the most part with oral oxycodone. One month prior to our evaluation of the patient, she was started on dapsone at 50 mg/day with no added benefit. Approximately 2 years prior to our evaluation, she developed raised, reddish, skin lesions on the abdomen and legs which recurred, but healed spontaneously each time after a few weeks. Her past medical history was remarkable for the remote use of intravenous drugs (which she had stopped for the past 20 years) and the past and continued use of alcohol on a daily basis. She had recently been tested elsewhere and was found to be positive for hepatitis C, but not human immunodeficiency virus (HIV). Examination revealed several ulcerations of the face and forehead, with an “apple jelly” coloration to the periphery and necrotic center. There was complete erosion of the nasal sidewall with apparent involvement of the septum (Fig. 1). There were also scattered, smaller, nonulcerated, reddish to purplish lesions on the abdomen. Otolaryngologic examination revealed ulceration of the right ala and erosion of the nasal septum, but was otherwise unremarkable. No cervical or submental lymphadenopathy was noted. 1 Facial ulceration at the time of initial evaluation Routine laboratory tests showed the patient to be anemic, with a hemoglobin level of 11 g/dL (normal, 12–15.5 g/dL) and a white blood count of 13,300 (normal, 3500–10,500) The total bilirubin was normal at 1.0 mg/dL, but several liver function tests were elevated by 2–4 times the upper limit of normal, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ‐glutamyl transpeptidase (G‐GT). Hepatitis C tests were abnormal, including antibody to hepatitis B core antigen (anti‐HBc) and anti‐hepatitis C virus (anti‐HCV) antibodies, and hepatitis C‐RNA was positive. Anti‐hepatitis B surface antigen (anti‐HBsAg) and antibody were negative. Human immunodeficiency virus (HIV) was negative. Antinuclear antibodies, antineutrophil cytoplasmic antibodies (ANCA), serologic tests for syphilis, cryoglobulins and cryofibrinogens, renal function, and urinalysis were all either negative or normal. The chest X‐ray showed bilateral pulmonary nodules, confirmed by computed tomography (CT) scan of the chest. Serologic tests for several fungal organisms, including Sporothrix and Cryptococcus, were negative. Tuberculin skin testing was negative. Two 4‐mm punch biopsies were taken from the right cheek and from the right lower lateral abdomen near the hip. Biopsy of facial tissue cultures for acid‐fast bacilli and fungal elements was negative. Bacterial culture revealed 1+Staphylococcus ...

show abstract

“…It has a very florid T-cell population, with a granulomatous infiltrate centred around blood vessels with severe vascular destruction. 11 It displays hyperplasia and involvement of the eccrine sweat glands, 12 and typically presents in the skin and/or lungs. Although our patient's tumour displayed an angiocentric pattern, the overall histology was very different.…”

Section: Discussionmentioning

confidence: 99%

A 62-year-old man presenting with widespread nodulo-ulcerative cutaneous lesions

Farrar

Jack

Lyon

et al. 2001

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

Lymphomatoid Granulomatosis of the Skin and Lung

Cited by 61 publications

References 38 publications

Cutaneous infiltrate of chronic lymphocytic leukemia and relationship to primary cutaneous epithelial neoplasms

Cutaneous infiltrate of chronic lymphocytic leukemia and relationship to primary cutaneous epithelial neoplasms

Destructive facial T‐cell lymphoma: the difficulty in diagnosis of pyoderma‐like processes

A 62-year-old man presenting with widespread nodulo-ulcerative cutaneous lesions

Contact Info

Product

Resources

About