Lymphomas Associated with Breast Implants: A Review of the Literature

Rupani, Asha; Frame, James D.; Kamel, Dia

doi:10.1093/asj/sjv016

Cited by 47 publications

(43 citation statements)

References 67 publications

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“…This association was highlighted by the Food and Drug Administration in the United States in 2011 (1, 2) and, whilst breast implants have been in use since 1962, the first case was only reported in 1997 (3). Since then, whether through increased use of implants, or growing clinician awareness and acceptance of this rare complication, the rate of diagnosis is rising: the latest literature review reports 173 cases (4,5). De Jong and colleagues estimate an incidence of BIA--ALCL of 1--3 cases in 1 million breast implant cases per year (6) however opinion in some other countries express possible higher risks (7) and more robust epidemiological studies are required.…”

mentioning

confidence: 99%

Breast implant associated anaplastic large cell lymphoma: The UK experience. Recommendations on its management and implications for informed consent

Johnson

O’Donoghue

McLean

et al. 2017

European Journal of Surgical Oncology (EJSO)

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confidence: 99%

Breast implant associated anaplastic large cell lymphoma: The UK experience. Recommendations on its management and implications for informed consent

Johnson

O’Donoghue

McLean

et al. 2017

European Journal of Surgical Oncology (EJSO)

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“…But breast carcinoma originating from a silicone granuloma has been reported (6). Considering so many women that have breast implants every year; the compiled data show that there is a very small risk of developing non-Hodgkin's lymphoma and anaplastic large cell lymphoma (7). Moreover, the relationship between breast augmentation and angiosarcoma of the breast remains unclear, but a few cases has been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Silicone Granuloma Associated with Pectoral Muscle Involvement after Ruptured Breast Implant: a Novel case report

İkizceli¹,

Gülşen

Akın

2018

Eur J Breast Health

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IntroductionSilicone has rapidly become one of the most commonly used prosthetic for breast implants over the last 30 years. Therefore, we have been witnessing more silicone-related disease. Silicone implant rupture, one of the most common silicone-related diseases, occurs more frequently with the implant's age. After implant rupture, silicone leakage can remain within the breast parenchyma or spread to regional lymph nodes first (1). Case studies report silicone migration to distal parts of the body, such as the arm, subcutaneous soft tissues of the abdominal wall and the inguinal area and even to the liver, where silicone causes foreign body inflammation and sometimes mimics malignancy (1). Silicone granuloma associated with pectoral muscle involvement has not been published before.In this study, an unusual case of a patient who was previously operated on a ruptured breast implant following silicone granuloma associated with pectoral muscle involvement is reported, and all imaging modality pattern are shown. Case PresentationA 72-year-old woman was referred to breast radiology department with a pain and hardness in her left breast. The patient had undergone bilateral subglandular breast augmentation surgery when she was 52-year-old. Ten years later, she had silicone implant rupture of left breast, required breast revision surgery and the breast implant and free silicone is removed without replacement. Her right breast was normal. After 10 years of ruptured silicone implant, she complained of pain, hardness, and swelling on her left breast. First of all, to determination of breast cancer and evaluation of the breast parenchyma changes after open removal surgery, a mammography (MG) and breast ultrasonography (US) were performed (IMS Giotto MD digital radiography and Tomosynthesis, Bologna, Italy). The MG showed; diffuse, multiple high-density nodules in the left breast, some with a thin rim of calcifications (Figure 1) Eur J Breast Health 2018; 14: 54-57 DOI: 10.5152/ejbh.2017.3499 54 ABSTRACTIn this study, an unusual case of a patient who was previously operated on a ruptured breast implant following silicone granuloma associated with pectoral muscle involvement is reported. A 72-year-old woman had undergone breast augmentation surgery when she was 52-year-old and silicone implant rupture 10 years later. After 10 years of ruptured silicone implant, her mammography showed diffuse, multiple high-density nodules in the left breast. The pectoral muscle was significantly hypertrophic. The magnetic resonance imaging showed that the pectoral muscle was quite hypertrophic and had heterogeneous enhancement. In clinical consideration and the presence of the suspected malignancy, a biopsy was performed. The histological analysis identified pectoral muscle and breast tissue, which had been mainly replaced by giant cells, along with an apparent foreign body response. Silicone granuloma can present itself as a soft tissue mass. Malignancy is the most important differential diagnosis. Meticulous follow-up is recommended ...

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“…Relatórios da comunidade científica sugeriram uma possível ligação entre o linfoma anaplásico quinase -linfoma anaplásico de células grandes (ALCL) negativo e implantes mamários [4,37]. O relatório da Administração de Alimentos e Medicamentos dos EUA de 2011 incluiu 17 artigos publicados entre 1997 e 2010 que representaram 34 pacientes com ALCL, uma forma rara de linfoma não-Hodgkin associado à forte expressão de CD30 [54]. Em 1997, Keech e Creech publicaram o relato de caso sentinela da ALCL associada a implantes mamários (BIA) [55].…”

Section: Linfoma Anaplástico De Grandes Célulasunclassified

Controvérsia sobre a Doença do Implante de Silicone Mamário: Uma revisão sistemática sobre o tema

Santos

Garcia

Amarante

et al. 2020

Braz. J. Implantol. Health Sci.

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Introdução: Atualmente, existem evidências esmagadoras para apoiar a segurança dos implantes mamários de silicone. A decisão obter, manter ou remover os implantes mamários é escolha da paciente. Se uma paciente optar por remover os implantes mamários, é importante encontrar um cirurgião plástico certificado pela Sociedade Brasileira de Cirurgia Plástica. Objetivos: O objetivo deste artigo é apresentar o estado atual das evidências científicas relacionadas à segurança dos implantes mamários de silicone. Os estudos em andamento são fortemente incentivados em todas as áreas, da detecção do câncer à doença auto-imune, cabendo ao profissional cirurgião plástico (a), o esforço necessário para melhorar a segurança, a conscientização e a educação do paciente. Metodologia: Foi pesquisado o termo “Silicone Implant Illness” nos portais de indexação Google Acadêmico, Scopus e Web of Sciences e foram selecionados 102 artigos com maior fator de impacto e citações. Conclusão: Até o presente momento, não existem estudos concretos ou baseados em evidências ou dados revisados por pares sobre a formação de uma nova síndrome.

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Lymphomas Associated with Breast Implants: A Review of the Literature

Abstract: 3

Cited by 47 publications

References 67 publications

Breast implant associated anaplastic large cell lymphoma: The UK experience. Recommendations on its management and implications for informed consent

Breast implant associated anaplastic large cell lymphoma: The UK experience. Recommendations on its management and implications for informed consent

Silicone Granuloma Associated with Pectoral Muscle Involvement after Ruptured Breast Implant: a Novel case report

Controvérsia sobre a Doença do Implante de Silicone Mamário: Uma revisão sistemática sobre o tema

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