Lymphomas and leukemias in the relatives of patients with mycosis fungoides

Greene, Mark H.; Pinto, Harlan A.; Kant, Jeffrey A.; Siler, Kathleen; Vonderheid, Eric C.; Dalager, Nancy A.

doi:10.1002/1097-0142(19820215)49:4<737::aid-cncr2820490423>3.0.co;2-r

Cited by 32 publications

(8 citation statements)

References 21 publications

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“…There may also be a direct effect of radiotherapy on lung cancer risk or shared environmental factors such as cigarette smokingz8 or occupational exposures as suspected in CTCL. 8,28,29 More surprising is the increased frequency of colon cancer after CTCL, which may be a clue to common exposures or susceptibility mechanisms. An excess of colon cancer has been suggested previously in CTCL patients' and in the context of familial occurrences of lymph~ma,~' including mycosis f~ngoides.~' It is possible, however, that heightened diagnostic surveillance may contribute to the excess of certain cancers such as colon.…”

Section: Discussionmentioning

confidence: 99%

Risk of second malignancy after cutaneous T-cell lymphoma

Kantor

Curtis

Vonderheid

et al. 1989

Cancer

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Risk of second primary malignancy was assessed in a population-based follow-up survey of all persons who developed cutaneous T-cell lymphoma (CI'CL) in nine geographic areas of the United States covered by the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute during the period 1973 to 1983. Among 544 patients with a first primary tumor reported as CI'CL, a second cancer developed in 35 (6%), yielding a significantly elevated relative risk (RR) of 1.7, which reflects excesses for cancers of the lung and colon and non-Hodgkin's lymphoma. Although the excess of lymphoma may be related to the evolution of CI'CL to less differentiated T-cell lymphoma, additional studies are needed to clarify the immunologic, genetic, viral, and environmental factors that may contribute to the development of second cancers. Cancer 63:1612-1615, 1989. YCOSIS FUNGOIDES and Sezary syndrome, collec-M tively termed cutaneous T-cell lymphoma (CTCL),are uncommon neoplasms characterized by malignant proliferation of T-lymphocytes in the skin. Altered immune response in CTCL, particularly with more advanced disease,' in addition to the effects of radiation, alkylating agents, and PUVA suggest that CTCL patients may be at increased risk of second primary malignancy. A recent follow-up of 63 patients with CTCL revealed a 2.4-fold excess of subsequent malignancy of diverse sites compared to general population rates.' Various second neoplasms after CTCL have been reported in clinical series,*-" but the patterns and determinants are not yet clear.Evaluation of second malignancy risk after CTCL has been difficult due to small numbers of patients usually available for study. Therefore, the current report analyzes the incidence of second primary cancers in a cohort of 544 CTCL patients reported to the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute, which has documented and followed since 1973 all newly diagnosed cases of cancer in selected states and metropolitan areas covering approximately 10% of the US population.

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Section: Discussionmentioning

confidence: 99%

Risk of second malignancy after cutaneous T-cell lymphoma

Kantor

Curtis

Vonderheid

et al. 1989

Cancer

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“…Familial non‐Hodgkin's lymphoma (NHL) cases were collected from two sources: the published medical literature ( Camino, 1975; Greene & Miller, 1978; Shelley, 1980; Greene et al , 1982 ; Haim et al , 1982 ; Veltri et al , 1983 ; Kato et al , 1989 ; Lynch et al , 1992 ; Hayoz et al , 1993 ; Donadieu et al , 1996 ; James et al , 1998 ) from 1926 to the present; and our series of unpublished families with multigenerational NHL. Additional information on one of the published families was obtained by personal communication with the author ( James et al , 1998 ).…”

Section: Methodsmentioning

confidence: 99%

Age of onset evidence for anticipation in familial non‐Hodgkin's lymphoma

Wiernik

Wang

et al. 2000

Br J Haematol

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Summary. Anticipation, a phenomenon in which an inherited disease is diagnosed at an earlier age in each successive generation of a family, has been demonstrated in certain neurological and haematological disorders. This study was conducted to determine whether anticipation occurs in familial non-Hodgkin's lymphoma (NHL). Eleven published reports of multigenerational familial NHL were analysed for evidence of anticipation, together with 18 previously unreported families with familial NHL. Differences in disease-free survival between generations were determined. The difference between age at onset for each affected parent±child pair was tested against the null hypothesis that there was no difference in age at onset. These analyses were also performed separately using only parent± child pairs with age of onset > 25 years to avoid ascertainment bias. In addition, the age at onset distribution of the studied cases was compared with that of the Surveillance Epidemiology and End Results (SEER) Program using data for 1973±98. The median ages at onset in the child and parent generations of all families (48´5 and 71´3 years respectively) and in the selected pairs (52´5 and 71´5 years respectively) were signi®cantly different (P < 0´000002 and P < 0´000001 respectively). The null hypothesis was rejected for all (P < 0´000001) as well as selected pairs (P < 0´000003). A signi®cant difference was observed between the ages of onset of the child generation and the SEER population (P < 0´009), but not between the parent generation and the SEER population. Anticipation occurs in familial NHL, which suggests a genetic basis for it.

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“…In eight cases, the Hodgkin's disease preceded the CTCL, in seven cases it followed the CTCL, and in five cases the diagnosis was made simultaneously (29). Green reported that in a series of 526 patients with mycosis fungoides, eight had first degree relatives with Hodgkin's disease (30). It is not clear whether there is a genetic relationship between the two lymphomas, whether they are caused by a similar etiologic agent, such as a virus, or whether chemotherapy and radiation are related to the development of the second lymphoma.…”

Section: Discussionmentioning

confidence: 99%