lymphoma type adult T‐cell leukemia—a clinicopathologic study of HTLV related T‐cell type malignant lymphoma

Abstract

The clinical and pathological features of T-cell type malignant lymphoma related to human T-cell leukemia virus (HTLV) were investigated in eight patients presenting lymphadenopathy. Biopsy of lymph nodes showed an histology of diffuse non-Hodgkin's lymphoma. All patients were positive for anti-ATLA antibody and HTLV proviral DNA in the lymph node cells. Most patients showed pronounced hypercalcemia and high serum levels of lactic dehydrogenase. All patients died between 3 and 17 months (mean 8 months) after the onset of disease. HTLV-related malignant lymphoma should be added to the spectrum of ATL, being classified as a lymphoma type ATL.

Adult T-Cell Leukemia/Lymphoma in a Renal Transplant Recipient: An Opportunistic Occurrence

“…Its role in ATL is established, particularly after early-life exposure [6], In HTLV-I-endemic areas such as Jamaica, where 65.8% of all peripheral T cell lymphomas are HTLV-I associated [19], it is not surprising that this type of malig nancy will also be encountered in the spectrum of second ary malignancies. The histological appearance of the tu mor is consistent with that seen in lymphoma-type ATL [20], and the T cell phenotype associated with HTLV-I seropositivity fulfilled the criteria for ATL [21], In Jamaica, the seroprevalence for HTLV-I is 3-7% [22], The most significant route of transmission for the development of ATL is from mother to infant via breast milk [6,23]. Sexual transmission in young adulthood car ries a much lower risk related to the long latency period necessary for the development of ATL [6], Acquisition of 228 Williams/Buchner/Shah/Williams Adult T-Cell Lcukemia/Lymphoma in a Renal Transplant Recipient HTLV-I by blood transfusion is more often associated with the development of tropical spastic paraparesis/ HTLV-l-associated myelopathy [24,25].…”

Clonal HTLV-I-infected CD4+ T-lymphocytes and non-clonal non-HTLV-I-infected giant cells in incipient ATLL with Hodgkin-like histologic features

“…Histologically, ATLL is categorized as of pleomorphic type (Takatsuki et al, 1992;Yamaguchi et al, 1986). In comparison, incipient ATLL shows Hodgkin-like histologic features (Ohshima 4).…”

“…Its characteristic clinicopathologic features include a rapidly progressing clinical course, accompanied by the appearance of tumor cells with flower-like nuclei in the peripheral blood, frequent lymphadenopathy and diffuse infiltration of various-sized neoplastic T cells with irregular nuclear contours in the lymph nodes (Takatsuki et al, 1992). There have been reports of patients in whom overt ATLL is preceded by smoldering clinical features and peculiar prodromal clinical manifestations (Yamaguchi et al, 1986). In these patients, integrated proviral HTLV-I DNA was present in T lymphocytes (Yoshida et al, 1984).…”

Major prognostic factors of Japanese patients with lymphoma‐type adult T‐cell leukemia

“…Adult T-cell leukemia (ATL) is a peripheral T-cell malignancy caused by the human T-cell leukemia virus type I (HTLV-I) [ 1,2]. The lymphoma type of ATL has recently been proposed as one in a spectrum of diseases that occur without typical ATL cells being identified in the peripheral blood [2][3][4].…”