Lymphoma Presenting as a Solitary Mass: Diagnosis by Fine Needle Aspiration Biopsy

P, Fýrat; Mocan, Gamze

doi:10.1046/j.1365-2303.2000.00236.x

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…This technique has an advantage over vitrectomy by providing increased concentration of viable cells for cytopathologic diagnosis and molecular studies. 38,39 Because of the varying presentation of PIOL, diagnosis is often delayed 10 to 21 months, after a mean of 4.3 diagnostic procedures. 8,12,15 Mishandling of vitreous specimens and prior treatment with corticosteroids at the time of vitrectomy, which are known to be cytolytic to lymphoma cells, 12 can lower the diagnostic yield.…”

Section: Ocular Tissue Diagnosismentioning

confidence: 99%

Intraocular Lymphoma: Update on Diagnosis and Management

2004

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Background: Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which lymphoma cells initially invade the retina, vitreous, or optic nerve head From the Laboratory of Immunology at the National Eye Institute, National Institutes of Health, Bethesda, Maryland. Submitted January 20, 2004; accepted April 12, 2004. Address correspondence to Chi-Chao Chan, MD, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N103, Bethesda, MD 20892. E-mail: chanc@nei.nih.gov No significant relationship exists between the authors and the companies/organizations whose products or services may be referenced in this article.Abbreviations used in this paper: CSF = cerebrospinal fluid; IgH = heavy chain immunoglobulin; mbr = major breakpoint region; mcr = minor cluster region; MTX = methotrexate; PCNSL = primary central nervous system lymphoma; PIOL = primary intraocular lymphoma; RPE = retinal pigment epithelium.

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Section: Ocular Tissue Diagnosismentioning

confidence: 99%

Intraocular Lymphoma: Update on Diagnosis and Management

2004

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“…[35][36][37][38][39][40] Fine-needle aspiration of intraocular mass lesions has been performed and can yield successful results. [41][42][43] Typically, chorioretinal biopsies and enucleated eyes demonstrate neoplastic cells between the RPE and Bruch's membrane. The tumor cells are large and hyperchromatic with prominent to conspicuous nucleoli.…”

Section: Figurementioning

confidence: 99%

Molecular pathology of primary intraocular lymphoma

Chan¹

2004

American Journal of Ophthalmology

129

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Silicone Fine-Needle Aspiration Retinal Biopsy

Globočnik Petrovič,

Vrabič,

Prevodnik Kloboves

et al. 2024

Retina

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Purpose: To describe a technique using a 41-gauge silicone fine needle aspiration biopsy (S-FNAB) and assess its value in diagnosing primary vitreoretinal lymphoma (PVRL). Methods: Retrospective review of seven consecutive patients who underwent vitreous biopsy and 41-gauge S-FNAB of retinal/subretinal lesions in a single tertiary center between January 2012 and March 2023. Results: Of seven patients, S-FNAB confirmed the diagnosis of PVRL in six patients. In five of those patients, both vitreous biopsy (VB) and retinal/subretinal S-FNAB (performed at the same procedure) yielded positive results, with the retinal thickness at the biopsy site as small as 231 μm. Four of these five patients had one or more previous negative VB. In one patient, S-FNAB yielded positive results despite a negative VB. S-FNAB failed to confirm positive VB for PVRL in the remaining patient. The time from symptom onset to diagnosis of PVRL ranged from 18 days to 26 months. There were no severe complications associated with the procedure. Conclusions. S-FNAB might be a valuable method for obtaining a sufficient sample of viable cells to diagnose PVRL. It can be performed as a primary procedure along with VB. Further studies are warranted to determine where this technique could be most advantageous.

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Lymphoma Presenting as a Solitary Mass: Diagnosis by Fine Needle Aspiration Biopsy

Cited by 3 publications

References 5 publications

Intraocular Lymphoma: Update on Diagnosis and Management

Intraocular Lymphoma: Update on Diagnosis and Management

Molecular pathology of primary intraocular lymphoma

Silicone Fine-Needle Aspiration Retinal Biopsy

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