Lymphoma of the uterine cervix- a rare clinical presentation: A case report

Abstract

Background/Aim. Lymphomas are malignant diseases of lymphocytes. There are two basic types of lymphoma: Hodgkin's lymphoma (HL) whose main characteristic is the presence of Reed-Sternberg cells and non-Hodgkin's lymphoma (NHL), which presents a heterogeneous group of diseases, and depending on the growth rate and the course of the disease, they can be indolent (slow-growing) and aggressive (fast-growing). Follicular lymphoma (FL) is the most common indolent form of NHL, while diffuse large B-cell lymphoma (DLBCL) is the most common aggressive form. Case report. This paper presents a case of NHL, DLBCL, localized in the cervix, histo-pathologically diagnosed in a 35-year-old woman who, after a cervical biopsy, was patho-histologically diagnosed with mild dysplasia (CIN1 / L-SIL) of the cervical epithelium and, after that, an infection with Human Papilloma Virus (HPV), subtypes 16 and 31 was proven. The diagnosis of DLBCL was patho-histologically confirmed on a conical section of the vaginal portion of the uterus, after which the disease was treated with eight cycles of chemotherapy (HT) according to the RCHOP protocol. Conclusion. The coexistence of CIN1 / L-SIL and NHL is random and may overlook concomitant cervical lymphoma, which is usually localized subepithelially, if the biopsy is not adequately performed and if HPV serotyping is not performed.