Lymphoma of the mediastinum and neck: evaluation with Ga-67 imaging and CT correlation.

Drossman, Susan R.; Schiff, Robert; Kronfeld, G D; McNamara, Joseph E.; Leonidas, John C.

doi:10.1148/radiology.174.1.2294545

Cited by 32 publications

(9 citation statements)

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“…Our results reported here are in agreement with those of Drossman et al [9] and strongly suggest that the value of Ga-67 imaging in patients with residual AMM lies in its ability to predict whether a residual mass represents active or recurrent disease. The disappearance or absence of Ga-67 uptake in the mediastinum in those with AMM may correspond to regression of tumor activity or nodal fibrosis.…”

Section: Discussionsupporting

confidence: 93%

“…This has been reported before and, based on the nature and intensity of chemotherapy, may represent regrowth during periods between chemotherapy cycles if there are sufficient time intervals [9,14,18]. Our patient was not noted to have any delays in chemotherapy cycles, and the reason for his thymic enlargement during chemotherapy cycles remains open to discussion.…”

Section: Discussionsupporting

confidence: 54%

“…The frequency of this "rebound" uptake in patients treated for a malignancy varies. One series reported this occurrence in 43% of patients <15 years of age; another reported it in 36% of children <5 years of age and in 15% in those over 5 years [9,14]. In a recent study, Benoit at al.…”

Section: Discussionmentioning

confidence: 99%

“…In a study of 19 patients with both Hodgkin disease and NHL (age 8-23 years), Drossman et al [9] showed the positive predictive value of Ga-67 imaging to be 73%, compared to 46% for CT scans. Rossleigh et al [23], using Ga-67 SPECT studies in 37 children, reported the sensitivity of SPECT to detect malignant lesions in the chest to be 96% (compared to 83% for planar imaging), whereas the specificity was 100% for both modalities of imaging.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, single photon emission computed tomography (SPECT) has been shown to be more accurate in depicting foci of galliumavid lymphoma in the chest and abdomen and in excluding disease when planar imaging was equivocal [6,7]. There has been some controversy regarding the usefulness of Ga-67 scanning in children [8,9]. Our goal was to evaluate the utility of Ga-67 (with SPECT) studies in pediatric patients with an anterior mediastinal mass (AMM) after successful/elective cessation of chemotherapy for NHL.…”

mentioning

confidence: 99%

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Anterior mediastinal mass in childhood non-Hodgkin lymphoma: Dilemma of post-therapy imaging

Bayar

Mathew

Jasty

et al. 2000

Med. Pediatr. Oncol.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Anterior mediastinal mass in childhood non-Hodgkin lymphoma: Dilemma of post-therapy imaging

Bayar

Mathew

Jasty

et al. 2000

Med. Pediatr. Oncol.

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Gallium-67 scans as an adjunct to computed tomography scans for the assessment of a residual mediastinal mass in pediatric patients with hodgkin's disease. A pediatric oncology group study

Weiner

Leventhal²,

Cantor

et al. 1991

Cancer

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This study determines the utility of gallium‐67 (Ga‐67) scintigraphs as an adjunct to computed tomography (CT) scans for the assessment of residual mediastinal masses in children and adolescents with advanced‐stage Hodgkin's disease. At diagnosis 42 patients with CT scan‐documented mediastinal disease had a Ga‐67 scan performed. Thirty‐four of 42 patients (81%) had gallium‐avid mediastinal lesions, whereas in eight (19%), the Ga‐67 scan was negative. At the completion of eight cycles of therapy of Mustargen (mechlorethamine), Oncovin (vincristine), procarbazine, prednisone (MOPP) alternating with doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD), 21 of 34 patients with initially positive Ga‐67 scans had them repeated; 18 of 21 converted to negative results, and three remained positive. In 11 of 18 patients, the loss of gallium avidity was consistent with a negative mediastinal CT scan. In seven, although the gallium scan was negative, the CT scan remained positive; all seven patients had a mediastinal biopsy of suspected residual disease and in all seven the biopsy results were negative for Hodgkin's disease. These preliminary results in a small cohort of patients demonstrate that Ga‐67 scans may be of benefit in evaluating residual mediastinal masses in patients with Hodgkin's disease. 68:2478‐2480, 1991.

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Current role of gallium scan and magnetic resonance imaging in the management of mediastinal Hodgkin lymphoma

Gasparini¹,

Balzarini²,

Castellani³

et al. 1993

Cancer

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Background. A residual mediastinal mass after treatment represents a common diagnostic problem in the management of patients with Hodgkin lymphoma (HD). Conventional diagnostic radiology, computed tomography (CT), or ultrasonography (US) do not adequately reflect changes as fibrosis or necrosis. Gallium‐67 (67Ga) imaging has been proven to be useful for the evaluation of HD in the mediastinum. The authors compared the ability of gallium scan and magnetic resonance imaging (MRI) to evaluate the mediastinal disease in the follow‐up of patients with HD. Methods. Thirty‐four patients previously treated for HD were investigated with gallium scan, MRI, and all the other investigations to evaluate the mediastinal region. Sixteen patients were in restaging after treatment, and 18 were investigated for suspected radiologic recurrence in the mediastinum (follow‐up, 9–75 months). The results of gallium scan and MRI were matched with clinical findings during the follow‐up. Results. A sensitivity of 85.7% for 67Ga and 92.8% for MRI was found, while the specificity was 100% for the scan and 80.6% for MRI. The predictive positive value that resulted was 100% for 67Ga and 68.4% for MRI. Conclusions. Both examinations were accurate in assessing the activity of residual masses in the mediastinum after treatment. 67Ga showed a lower sensitivity in comparison with MRI, but 67Ga frequently overestimates the presence of pathologic tissue. The authors acknowledge the complementary role of these two tests, but if only one of these examinations can be performed for logistic or economic reasons, then gallium scan represents the single most adequate diagnostic procedure.

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Lymphoma of the mediastinum and neck: evaluation with Ga-67 imaging and CT correlation.

Cited by 32 publications

References 0 publications

Anterior mediastinal mass in childhood non-Hodgkin lymphoma: Dilemma of post-therapy imaging

Anterior mediastinal mass in childhood non-Hodgkin lymphoma: Dilemma of post-therapy imaging

Gallium-67 scans as an adjunct to computed tomography scans for the assessment of a residual mediastinal mass in pediatric patients with hodgkin's disease. A pediatric oncology group study

Current role of gallium scan and magnetic resonance imaging in the management of mediastinal Hodgkin lymphoma

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