Lymphoma in the setting of autoimmune diseases: A review of association and mechanisms

Khanmohammadi, Shaghayegh; Shabani, Mahsima; Tabary, Mohammadreza; Rayzan, Elham; Rezaei, Nima

doi:10.1016/j.critrevonc.2020.102945

Cited by 18 publications

(8 citation statements)

References 54 publications

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“…Lymphoma: Every year, approximately 500000 people are diagnosed with non-Hodgkin's lymphoma and 80000 with Hodgkin's lymphoma, the most common cancers among the 90 lymphoma subtypes[ 186 ]. In a study conducted in China, a significantly decreased frequency of Th17 cells was observed in the peripheral blood of patients with non-Hodgkin's B-cell lymphoma compared to healthy individuals, along with an increase in Th1 cells[ 187 ].…”

Section: Association Between Th17 Response and Different Types Of Cancermentioning

confidence: 99%

Relationship between Th17 immune response and cancer

Marques¹,

Brito²,

Silva³

et al. 2021

WJCO

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Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades. Cancer has a close relationship with the immune system and, although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity, studies have emphasized their roles in cancer pathogenesis. The Th17 immune response profile is involved in several types of cancer including urogenital, respiratory, gastrointestinal, and skin cancers. This type of immune response exerts pro and antitumor functions through several mechanisms, depending on the context of each tumor, including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment. Among other factors, the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential, which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells. Interleukin (IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment, which allow Th17 cells to prevail in tumors. Moreover, the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers, being associated with variable clinical outcomes. The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

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Section: Association Between Th17 Response and Different Types Of Cancermentioning

confidence: 99%

Relationship between Th17 immune response and cancer

Marques¹,

Brito²,

Silva³

et al. 2021

WJCO

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“…Autoimmune disease is characterized by impaired self‐tolerance 22 . The typical autoimmune diseases associated with T cells include rheumatoid arthritis, SLE, primary Sjögren syndrome and type 1 diabetes 69 . Cytokines play an essential role in the occurrence of autoimmune disease.…”

Section: Altered Autophagy In T Cells and Inflammation Autoimmune DImentioning

confidence: 99%

Autophagy in T‐cell differentiation, survival and memory

Wang

Das

Kumar

et al. 2020

Immunol. Cell Biol.

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Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.

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“…Specifically, IL-10 is relevant because the presence of high levels of this cytokine can alter the delicate balance existing between T helper 1 (Th1) and 2 (Th2) lymphocytes. In this regard, Khanmohammad et al [10] showed that the presence and contribution of cytokines are essential, especially for specific gene polymorphisms.…”

Section: Pathophysiology Of the Connection Between Aid And Lymphomamentioning

confidence: 99%

“…It has also been proposed that the Fas receptor could be involved in both the development of AID and of lymphoproliferative diseases since, under physiological conditions, it is responsible for triggering the apoptosis process of self-reactive B and T lymphocytes. Therefore, a down-regulation of the Fas gene would make the self-reactive cells resistant to this process [10] (Figure 1).…”

Section: Pathophysiology Of the Connection Between Aid And Lymphomamentioning

confidence: 99%

The Role of Autoimmune Diseases in the Prognosis of Lymphoma

Masciopinto

Dell’Olio

Robertis

et al. 2020

JCM

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The connection between autoimmune disease (AID) and lymphoproliferative disorders is a complex bidirectional relationship that has long been a focus of attention by researchers and physicians. Although advances in pathobiology knowledge have ascertained an AID role in the development of lymphoproliferative diseases developing, results about AID influence on the prognosis of lymphoma are discordant. In this review, we collect the most relevant literature debating a direct or indirect link between immune-mediated diseases and lymphoma prognosis. We also consider the molecular, genetic, and microenvironmental factors involved in the pathobiology of these diseases in order to gain a deeper understanding of the nature of this link.

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Lymphoma in the setting of autoimmune diseases: A review of association and mechanisms

Cited by 18 publications

References 54 publications

Relationship between Th17 immune response and cancer

Relationship between Th17 immune response and cancer

Autophagy in T‐cell differentiation, survival and memory

The Role of Autoimmune Diseases in the Prognosis of Lymphoma

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