Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas)

Drexler, Hans; Uphoff, Cord C.; Gaïdano, Gianluca; Carbone, Antonino

doi:10.1038/sj.leu.2401160

Cited by 119 publications

(96 citation statements)

References 24 publications

(53 reference statements)

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“…33 The biologic and molecular mechanisms leading to neoplastic transformation and growth of this peculiar lymphoma require further investigation and cell line models will be invaluable tools for both in vitro and in vivo studies. 34 Despite the apparently local growth of primary effusion lymphomas, our investigation demonstrates the early neoplastic spread to the bone marrow suggesting that the treatment of this peculiar lymphoma would be necessarily systemic. On the other hand, the role of multidrug resistance requires more extensive studies but its association with the proven toxicity of chemotherapy programs in immunocompromised patients, underlines the urgent need to explore different treatment modalities, such as the use of new antiviral drugs capable of inhibiting the virus replication 35 and new biological response modifiers.…”

Section: Discussionmentioning

confidence: 73%

True

1999

Leukemia

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Deep immunosuppression and Epstein-Barr virus (EBV) infection promote the emergence of lymphoproliferative disorders in patients undergoing solid organ transplantation. In the last few years a new herpesvirus, named human herpesvirus-8 (HHV-8), has been identified in Kaposi's sarcoma and primary effusion lymphoma (PEL) developing in AIDS patients. Subsequently, the same viral DNA sequences have been identified in almost all cases of Kaposi's sarcoma emerged outside HIV infection, thus suggesting their possible pathogenetic role in this tumor. Similarly, the association between HHV-8 and PEL also emerged in cases without HIV infection, even though the total number of these patients is still limited. Here, we focus on the emergence of this unusual lymphoma in patients undergoing solid organ transplant and underline once again its association with the HHV-8. Moreover, despite the characteristic local growth of this peculiar type of lymphoma, we demonstrate at the molecular level, an early neoplastic spread to the bone marrow suggesting the need to investigate in more detail the origin of the disease, as well as the molecular mechanisms controlling its systemic dissemination.

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Section: Discussionmentioning

confidence: 73%

True

1999

Leukemia

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“…In the setting of AIDS, the clinical course for most of these lymphomas is extremely aggressive, with a mean survival from diagnosis of 5-7 months . While PELs are almost universally KSHV positive, the majority of PELs have concomitant EBV infection (reviewed in Dourmishev et al, 2003;Drexler et al, 1998;Moore and Chang, 2001). EBV apparently establishes levels type II latency in PELs with low of LMP-1 expression (Callahan et al, 1999;Fassone et al, 2000;Horenstein et al, 1997;Lacoste et al, 2000).…”

Section: B Primary Effusion Lymphomamentioning

confidence: 99%

The Viral Etiology of AIDS‐Associated Malignancies

Angeletti

Zhang

Wood

2008

Advances in Pharmacology

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“…The PEL cell lines forming the basis of this study were HBL-6, BC-1, BC-2, CRO-AP/2, CRO-AP/3, CRO-AP/5, BCBL-1, BC-3 and BCP-1. [23][24][25][26][27][28][29][30] The detailed characterization of these cell lines has been reported previously. 23 31,32 Seven out of nine PEL specimens were derived from HIV-infected patients, whereas two PEL samples (BC-3 and BCP-1) were derived from HIV-negative individuals.…”

Section: Patient Samples and Tumor Cell Linesmentioning

confidence: 99%