2013
DOI: 10.1007/s00277-013-1784-3
|View full text |Cite
|
Sign up to set email alerts
|

Lymphoma-associated hemophagocytic lymphohistiocytosis: experience in adults from a single institution

Abstract: Lymphoma-associated hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disease. Differences between B cell and T cell lymphoma-associated HLH remain unclear, specifically clinical characteristics and survival. We retrospectively analyzed 30 lymphoma-associated HLH patients from July 2004 to October 2012. Patients were divided into B cell (n = 13) and T cell (n = 17) lymphoma groups. Patients' age, performance status, presence of Epstein-Barr virus infection, international prognostic index, presence o… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

6
41
3
2

Year Published

2014
2014
2019
2019

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 70 publications
(52 citation statements)
references
References 24 publications
6
41
3
2
Order By: Relevance
“…[9][10][11] The incidence and mortality of HLH in T-cell lymphoma is especially high. 5 No malignancy or other cause was identified in patients 3 and 6, despite multiple investigations that were performed.…”
Section: Patient Characteristics and Laboratory Findingsmentioning
confidence: 99%
“…[9][10][11] The incidence and mortality of HLH in T-cell lymphoma is especially high. 5 No malignancy or other cause was identified in patients 3 and 6, despite multiple investigations that were performed.…”
Section: Patient Characteristics and Laboratory Findingsmentioning
confidence: 99%
“…The overall mortality associated with malignancy-associated HLH is .90%, and chemotherapy may not salvage these patients because of endorgan dysfunction at presentation. 92,93 Treatment of lymphomaassociated HLH (LA-HLH) involves HLH-94/HLH-2004 protocol and treating the underlying B-or T-cell lymphoma with chemotherapy. The majority of B-cell lymphoma-related HLH was DLBCL and treatment consisted of rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone.…”
Section: Treatmentmentioning
confidence: 99%
“…For adults, transplantation using two cord units is frequently necessary [3][4][5] and literature demonstrates that double umbilical cord blood transplantation (DUCT) yields durable remissions [1,5,6]. Data on DUCT in hepatosplenic gamma-delta T-cell lymphoma with hemophagocytic lymphohistiocytosis (HLH) are limited to case reports [7,8]. We describe a 22-year-old woman with hepatosplenic gamma-delta lymphoma with hemophagocytosis treated with DUCT.…”
mentioning
confidence: 99%