Lymphokines and bacteria, that induce tumoricidal activity, trigger a different secretory response in macrophages

Keller, R.; Keist, Ruth; Frei, Karl

doi:10.1002/eji.1830200334

Cited by 47 publications

(32 citation statements)

References 26 publications

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“…Thus, lymphokine-triggered cytotoxic activity in bone marrow-derived phagocytes declines after 24 h, but that elicited by bacteria persists (Keller et al, 1990). Furthermore, the secretion of IL-6 and prostaglandin E2 (PGE2) is enhanced by bacteria but not by lymphokines.…”

Section: Discussionmentioning

confidence: 99%

Bacillus Calmette-Guerin (BCG) enhances monocyte- and lymphocyte-mediated bladder tumour cell killing

Pryor

Goddard²,

Goldstein³

et al. 1995

Br J Cancer

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Section: Discussionmentioning

confidence: 99%

Bacillus Calmette-Guerin (BCG) enhances monocyte- and lymphocyte-mediated bladder tumour cell killing

Pryor

Goddard²,

Goldstein³

et al. 1995

Br J Cancer

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“…Peritoneal macrophages can be stimulated by a variety of agents such as IFN-γ, lipopolysaccharides, or other microbial products [17][18][19] and some of these have also been shown to trigger the release of TNF-α, IL-1β and IL-6 by the macrophages [20][21][22][23]. Peritoneal macrophages proliferation result showed that from 100 µg/mL to 300 µg/mL, TCDCA appeared markedly progressing inhibition, and its inhibited rates reached to 10%, 20% and 30% in the concentration of TCDCA 150 µg/mL, 180 µg/mLand 200 µg/mL, respectively (Figure 3).…”

Section: Effects Of Tcdca On Expression Of Iκbα and Phospho-iκbαmentioning

confidence: 99%

Taurochenodeoxycholic Acid Suppresses NF-κB Activation and Related Cytokines Expression in Peritoneal Macrophages from Adjuvant Arthritis Rat

Mao¹,

Liu²,

Guan³

et al. 2018

Rec.Nat.Prod.

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Taurochenodeoxycholic acid (TCDCA) is one of main bioactive substances of animals' bile acid and confers good anti-inflammatory activity. This study aimed to investigate the mechanism of the anti-adjuvant arthritis activity of TCDCA, the actions were observed in vitro on the protein and mRNA expression of cytokines, the activity of nuclear factor-kappa B (NF-κB) and its inhibitory IκBα protein level of peritoneal macrophages (PMs) in adjuvant arthritis (AA) rats. In a definite concentration ranging from 150 μg/mL to 200 μg/mL, the over protein and mRNA expression of TNF-α, IL-1β and IL-6 were remarkably suppressed in the supernatant of PMs treatment with TCDCA. Positive correlations were found between changes of NF-κB activity and expression of TNF-α, IL-1β and IL-6 influenced by TCDCA. The activity of NF-κB was markedly inhibited and IκBα protein level was increased by TCDCA (150 μg/mL,180 μg/mL and 200 μg/mL). TCDCA suppresses the protein and mRNA expression of TNF-α, IL-1β, and IL-6 by inhibiting the NF-κB binding activity, which is mediated through up-regulating the IκBα expression of PMs in AA rats.

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“…NO, one of the smallest biological molecular mediators plays important roles in many different aspects of mammalian biology, such as vascular relaxation, neurotransmission, platelet aggregation and immune regulation (Hemmi and Ishida, 1980;Hibbs et al, 1988). Since NO is related to cytostatic or cytotoxic function of macrophages against a variety of tumors (Hibbs et al, 1987;Keller et al, 1990), we examined the effects of EBE on the NO production from macrophages in exercise-stress rats. It is known that iNOS is expressed in many different cell types and produces high levels of NO.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effects of Eisenia bicyclis on Innate Immune Cells in Acute Exercise-Stress Rat Model

Namkoong¹,

Cheoung²,

Joo³

et al. 2011

Korean Journal of Plant Resources

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-In this study we investigated effects of supplementation with ethyl acetate extracts of the brown alga Eisenia bicyclis on innate immune cells to evaluate the possibilities as an immunomoulator in exercise stress. Twenty male SD rats were divided into four groups and the treatments were as follows: A, no Eisenia bicyclis extract (EBE) (200 mg/kg) intake and maintained at rest ; B, no EBE intake and undergoing exercise ; C, EBE intake and undergoing exercise ; D, EBE intake and maintained at rest. After 5 weeks of oral supplementation, rats were undergoing intensive swimming exercises for 2 h and sacrificed to assess the effects on peritoneal macrophages, spleen cells and natural killer (NK) cells. We showed increasing effects on nitric oxide-inducible nitric oxide synthase (NO-iNOS) production by macrophages and no effects of NK tumoricidal activity and suppressive effects on spleen cell proliferation in exercise group. However, EBE supplementation suppressed NO-iNOS production by macrophages and increased NK tumoricidal activity and spleen cell proliferative response to mitogen in exercise group. Overall, these results that EBE supplementation has differential effects on innate immune response and could be useful as sports nutrition.

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Lymphokines and bacteria, that induce tumoricidal activity, trigger a different secretory response in macrophages

Cited by 47 publications

References 26 publications

Bacillus Calmette-Guerin (BCG) enhances monocyte- and lymphocyte-mediated bladder tumour cell killing

Bacillus Calmette-Guerin (BCG) enhances monocyte- and lymphocyte-mediated bladder tumour cell killing

Taurochenodeoxycholic Acid Suppresses NF-κB Activation and Related Cytokines Expression in Peritoneal Macrophages from Adjuvant Arthritis Rat

Immunomodulatory Effects of Eisenia bicyclis on Innate Immune Cells in Acute Exercise-Stress Rat Model

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