Lymphoid tissue responses to perfluorocarbon emulsion in mice

Bollands, A.D.; Lowe, K. C.

doi:10.1016/0742-8413(87)90109-5

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Ex periments in several species, including man, have shown that in vivo use of PFC emulsions can produce temporary RES blockade [52]. Moreover, animal experiments have shown that PFC effects on the humoral immune re sponses to immunological 'challenges' are highly variable and dependent on: (1) emulsion composition, (2) dose and route of administration, (3) tissue and species in volved, and (4) timing of emulsion administration rela tive to immune challenge [49,[53][54][55][56], Such variability has inevitably introduced difficulties in assessing the effects of different PFC emulsions on immunological compe tence. The fact that responses are highly species specific also makes it difficult to extrapolate from laboratory ani mals into man.…”

Section: Effects On Lymphoid Tissues and Immunological Competencementioning

confidence: 99%

Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

Lowe¹

1991

Vox Sanguinis

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Recent advances in the development and assessment of synthetic oxygen transport fluids based on perfluorochemicals (PFCs) are reviewed. The basic properties of PFCs are outlined, together with the selection criteria for biomedical applications. PFCs must be emulsified for intravascular use and attention is focussed on the formulation and biocompatibility testing of both first- and second-generation emulsions and their components in man and other species. The multidisciplinary applications for PFCs in medicine and basic biomedical research are described, including the clinical use of Fluosol-DA 20% as an oxygen-carrying perfusate in percutaneous transluminal coronary angioplasty.

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