Lymphoid proliferations in the orbit: malignant or benign?

Gaag, R van der; Koornneef, L.; Heerde, P. Van; Vroom, Thea M.; Pegels, J H; Feltkamp, Constance A.; Peeters, H. J. F.; Gillissen, Jan P. M.; Bleeker, Gitta; Feltkamp, T. E. W.

doi:10.1136/bjo.68.12.892

Cited by 21 publications

(5 citation statements)

References 18 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Though the pathogenesis of Graves' ophthalmopathy is still unclear, many investigators have proposed an autoimmune mechanism [29][30][31][32][33][34][35][36][37][38][39][40]. As the histological evidence of autoimmunity, lymphocyte and macrophage infiltration and peptide factors such as IL-1a, TNFa, IFNy, TGF/3, PDGF and IGF-I, were detected in retroorbital tissues [41][42][43][44].…”

Section: Patients and Methods Statistical Methodsmentioning

confidence: 99%

Significance of Thyroid Stimulating Antibody and Long Term Follow Up in Patients with Euthyroid Graves' Disease.

et al. 1995

View full text Add to dashboard Cite

show abstract

Section: Patients and Methods Statistical Methodsmentioning

confidence: 99%

Significance of Thyroid Stimulating Antibody and Long Term Follow Up in Patients with Euthyroid Graves' Disease.

et al. 1995

View full text Add to dashboard Cite

show abstract

“…Lymphoproliferative diseases account for 15% of all space-occupying lesions in orbit [1]. Distinguishing them as benign or malignant lesions is always a diagnostic challenge.…”

Section: Discussionmentioning

confidence: 99%

Proptosis under evaluation—a rare case report on pseudolymphoma of orbit

Raguraman

Kushwaha

Penubarthi

2023

Egypt J Otolaryngol

View full text Add to dashboard Cite

Background Orbital pseudolymphoma is one of the rare diseases affecting the ocular adnexa and causing various symptoms requiring histopathological evidence for diagnosis and appropriate treatment with oral steroids or immunosuppressive agents. However, there is less literature available on this disease, thus adding to it will help in the early diagnosis and treatment of the patients. Case presentation A 48-year-old female from a village in South India came to our tertiary care centre with the only complaints of right eye protrusion for 1 year. With a working diagnosis of intraorbital mass, radiological investigations like contrast-enhanced CT and MRI were taken. It showed well-capsulated mass involving the right inferior rectus extending into the intraconal space just abutting the optic nerve. Trans-antral endoscopic biopsy under general anaesthesia was taken and reported as pseudolymphoma proven with CD 3 and CD 20 immunohistochemistry markers. The patient was treated with oral corticosteroids and tapered over a period of 3 months. During the treatment period, the patient developed no diminution of vision or new complaints. Conclusion Orbital pseudolymphomas are benign lymphoproliferative diseases affecting the ocular adnexal tissue. Patients can present with painless ptosis, proptosis, diplopia, or eyelid swelling. Prompt diagnosis and treatment result in the remission of the disease.

show abstract

“…Several immune-mediated diseases occur in orbital tissues despite the absence of systemic immune abnor¬ malities (van der Gaag, Koornneef, van Heerde et al 1984;van der Gaag, 1988). Although debated, the orbit seems to lack both lymphatics and drainage to a regional lymph node (Rouvière, 1932;Campbell, 1984;McGetrick, Douglas, Dortzbach et al 1989).…”

Section: Introductionmentioning

confidence: 97%

Site-dependent effects of experimental hypo- and hyperthyroidism on resident macrophages in extraocular muscles of rats: a quantitative immunohistochemical study

Schmidt¹,

Hogerwou²,

Gaag³

et al. 1992

Journal of Endocrinology

View full text Add to dashboard Cite

It has been suggested that the effects of dysthyroidism on resident immunocompetent cells of the extraocular muscles may play a role in the pathogenesis of Graves' ophthalmopathy. The distribution of such cells was therefore studied in extraocular muscles of rats that were made hyper- or hypothyroid by the oral administration of thyroxine or propylthiouracil respectively. Skeletal muscles were studied for comparison. The cell distributions were analysed in cryostat cross-sections subjected to a two-step immunoperoxidase method using well-characterized monoclonal antibodies against T cells, B cells, macrophages and MHC class II antigens. The extraocular muscles of control (euthyroid) rats contained numerous macrophages, fewer MHC-II positive cells and T cells and no B cells. Differences in the distribution of immunocompetent cells were found in control rats, between skeletal and extraocular muscles as well as within the various recti eye muscles. This particular tissue distribution resembles that previously reported for human extraocular and skeletal muscles. Quantitative analysis showed that experimental dysthyroidism only affected cell populations in the extraocular muscles. Significant effects on the number of macrophages were observed in the inferior rectus muscle of both hypo- and hyperthyroid rats, this was most pronounced in the orbital layer of the muscles. Both hyper- and hypothyroidism appear to affect local cell distributions in a tissue-specific manner. The presently observed site-dependent effects of dysthyroidism on local immunocompetent cell populations may have relevance for the differential involvement of muscular tissues in Graves' ophthalmopathy.

show abstract

Lymphoid proliferations in the orbit: malignant or benign?

Cited by 21 publications

References 18 publications

Significance of Thyroid Stimulating Antibody and Long Term Follow Up in Patients with Euthyroid Graves' Disease.

Significance of Thyroid Stimulating Antibody and Long Term Follow Up in Patients with Euthyroid Graves' Disease.

Proptosis under evaluation—a rare case report on pseudolymphoma of orbit

Site-dependent effects of experimental hypo- and hyperthyroidism on resident macrophages in extraocular muscles of rats: a quantitative immunohistochemical study

Contact Info

Product

Resources

About