Lymphoid Hyperplasia of the Colon in Children

Capitanio, Marie A.; Kirkpatrick, John A.

doi:10.1148/94.2.323

Cited by 95 publications

(36 citation statements)

References 8 publications

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“…Lymphoid nodular hyperplasia is part of the generalized lymphoid hyperplasia associated with viral infections in infancy and childhood and immunodeficiency states as a cause of the lymphoid hyperplasia should always be excluded by estimation of serum immunoglobulin (22). Capitanio MA et al (23) reported a rectal bleeding caused by the lymphoid hyperplasia. Lymphoid nodular hyperplasia should be considered as a differential diagnosis of LGIB in every infant who presents with LGIB under age of 2 years especially in breast fed infants.…”

Section: Discussionmentioning

confidence: 99%

Lower Gastrointestinal Bleeding in Children: Experiences From Referral Center in Southern Iran

et al. 2013

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Background: Lower gastrointestinal bleeding (LGIB) in infants and children is a common problem in medical centers; however, its epidemiologic properties have not been studied well. Objectives: Due to the fact that LGIB has various causes in different geographical places, considering the importance of etiology in decision making for diagnostic techniques and treatment and since the lack of comprehensive database related to this issue, the main purpose of the current study was to determine the main causes of LGIB in children in a single center from Southern Iran. Patients and Methods:The study was conducted on all the patients less than 18 years old with LGIB who referred to Pediatric Gastroenterology Ward affiliated with Shiraz University of Medical Sciences between 2005 and 2009. The data, including the patients' sex, age, and endoscopic as well as pathological findings, were collected and analyzed. Results: Overall, our series included a total of 309 patients with LGIB (185 males and 124 females) below 18 years old. The most common causes of LGIB included colorectal polyps (n = 90; 29.1%), lymphoid nodular hyperplasia (n = 62; 20%), solitary rectal ulcer (n = 31; 10%), and inflammatory bowel disease (n = 20; 6.5%). Nevertheless, no obvious causes were identified in 30.7% of the patients. The prevalence of lymphoid nodular hyperplasia in less than 2 years old patients and colorectal polyps in the 2-6 years old patients were significantly higher than the other causes (P = 0.001). The most cases with inflammatory bowel diseases and solitary rectal ulcer were more than 2 years old. On the other hand, no statistically significant differences were observed between males and females as well as different age groups regarding the means of the underlying causes of LGIB (P > 0.05). Conclusions:The results of present study could be used by the Iranian physicians in order to gain an overall picture of LGIB in Iran and guide the management of the patients with LGIB.

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Section: Discussionmentioning

confidence: 99%

Lower Gastrointestinal Bleeding in Children: Experiences From Referral Center in Southern Iran

et al. 2013

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“…The term "lymphoid hyperplasia" was first introduced in 1970 by Capitanio & Lirkpatrick to describe numerous lymphoid follicles with an average diameter of 2 mm (9,11,12). Typical endoscopic findings of lymphoid hyperplasia include multiple nodular, closely spaced, yellowish-white polyps measuring 1-2 mm in diameter (9).…”

Section: Hematoxylin and Eosin Staining (A) And Immunostainings (B-e)mentioning

confidence: 99%

Reactive Lymphoid Hyperplasia with a Lipomatous Component Associated with Fecal Compaction in an Appendiceal Orifice

et al. 2014

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A 69-year-old man underwent endoscopic mucosal resection of a solitary polyp located in the cecum. After the procedure, a fecal mass and appendiceal orifice appeared under the cut surface. A diagnosis of reactive lymphoid hyperplasia was made based on the results of an immunostaining analysis, which revealed a segregated population of T cells and B cells in multiple lymphoid follicles. The aggregation of adipocytes forming a lipomatous area and granulation tissue was also observed. We speculate that the compaction of the fecal mass in the appendix triggered mucosal inflammation, resulting in the formation of the polyp, which concealed both the feces and appendiceal orifice.

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“…Even when lymphoid hyperplasia is of no clinical significance, it is thought to result from a wide variety of stimuli to the large bowel (9,13,14). Diseases associated with lymphoid hyperplasia include milk allergy (9), bacterial and viral infection (9, 18, 19), Crohn's disease (12, 13, 15, 16), ulcerative colitis (15, 16), colorectal cancer (16, 17), sarcoidosis (19), and immunoglobulin deficiency (20).…”

Section: Clinical Coursementioning

confidence: 99%

Crohn's Disease Associated with Diffuse Lymphoid Hyperplasia of the Large Intestine. A Possible Role of the Lymph Follicle in HLA-DR Antigen Expression on Epithelium.

et al. 1992

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A 14-year-old girl diagnosed as Crohn's disease had lymphoid hyperplasia throughout the large bowel. Biopsy specimens from the lymphoid hyperplasia demonstrated non-caseous granulomas within the lymph follicles. An immuno-histochemical study of biopsy specimens showed that HLA-DR antigens were expressed on epithelium close to the lymph follicle, which was observed in all specimens containing the lymph follicle. This case provides evidence for the importance of the lymph follicle in the etiopathogenesis of Crohn's disease by demonstration of non-caseous granulomas within the lymph follicle and expression of HLA-DR antigens on epithelium close to the lymph follicle.

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Lymphoid Hyperplasia of the Colon in Children

Cited by 95 publications

References 8 publications

Lower Gastrointestinal Bleeding in Children: Experiences From Referral Center in Southern Iran

Lower Gastrointestinal Bleeding in Children: Experiences From Referral Center in Southern Iran

Reactive Lymphoid Hyperplasia with a Lipomatous Component Associated with Fecal Compaction in an Appendiceal Orifice

Crohn's Disease Associated with Diffuse Lymphoid Hyperplasia of the Large Intestine. A Possible Role of the Lymph Follicle in HLA-DR Antigen Expression on Epithelium.

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