Lymphoepithelioma-like Carcinoma of the Ovary

Abstract

Lymphoepithelioma-like carcinoma (LELC), which is commonly reported in the nasopharynx and occasionally in other organs, remains a rare condition in gynecology. It is morphologically defined as a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltrate. We present a case of an 82-year-old woman with a 10 cm LELC of the ovary shown by inguinal lymph nodes. There was no peritoneal carcinomatosis. Cytoreductive surgery was performed to remove a left ovarian neoplasm and multiple involved lymph nodes. Cytoreduction was complete. The tumor was a mixed poorly undifferentiated ovarian carcinoma consisting of 95% LELC and 5% moderately differentiated serous adenocarcinoma. Immunohistochemistry showed a large infiltration of T lymphocytes and plasma cells. Epstein-Barr virus was not detected by immunolabeling and polymerase chain reaction. The patient was still alive at 24 months of follow-up. To our knowledge, this is the second case of ovarian LELC and the first description of the native tumor before chemotherapy. In conclusion, this rare tumor of the ovary is difficult to diagnose both preoperatively and perioperatively. However, clinicians and pathologists should be aware that ovarian tumors with massive involvement of lymph nodes and no peritoneal carcinomatosis are suggestive of such a diagnosis and that prognosis is relatively good.

PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium

“…In the genital tract, this pathological entity is very rare, mainly described in the cervix, where it could be associated with Human Papillomavirus (HPV) infection [4–7]. Exceptionally, these tumors have been also encountered in the rest of genital tract including vulva, vagina, ovary, and endometrium [8–11]. In the endometrium, to the best of our knowledge, only 5 cases of lymphoepithelioma-like carcinoma have been reported [12–16].…”

Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

“…Lymphoepithelioma-like carcinoma (LELC) of the skin, however, is a rare condition [1-4] and only three cases have been reported in the vulvar region [5-7]. The same is true for other sites of the female genital tract with some cases described in the uterine cervix [8-14], two reports each in the ovary [15], the endometrium [16,12], and the vagina [17,18], and only one in the Bartholin gland [19]. In contrast to LELC of the nasopharynx, there is usually no evidence for an association with EBV, but cervical LELC is commonly associated with human papilloma virus [20-23].…”