Lymphoepithelioma‐like carcinoma of the lung

Miller, Barry; Montgomery, Charles A.; Watne, Alvin L.; Johnson, D. H.; Bailey, T; Kowalski, Ronald

doi:10.1002/jso.2930480112

Cited by 25 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare cancer, with known associations with the Epstein-Barr virus (EBV) [1,2,3,4,5,6,7,8,9,10,11]. Begin et al first described [12] this condition in 1987, and since then there have been 91 cases reported in the literature, including the present series [1,2,3,4,5,6,7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 74%

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Ooi

Khong

et al. 2003

Eur Radiol

View full text Add to dashboard Cite

Our objectives were to document CT features of advanced primary pulmonary lymphoepithelioma-like carcinoma (LELC) and to determine features that may assist differentiation from other non-small cell lung cancers (NSCLC). Imaging and clinical data of all patients with biopsy-proven pulmonary LELC (n=12) were retrieved from a database of all NSCLC patients over a 2-year period. Twenty-five controls were recruited from other inoperable non-LELC NSCLC patients from the database. Pre-treatment CT scans of the thorax of both study and control patients were reviewed for lobe involved; tumour site, borders and size; and pleural, vascular or pulmonary involvement. Presence of lymphangitis carcinomatosis was noted. Lymph node metastasis was characterised as ipsilateral or contralateral enlarged (>1 cm) mediastinal or hilar nodes, or as peribronchovas-cular nodal spread. Differences between the two groups were tested using Mann-Whitney rank-sum test. The LELC tumours were significantly larger (45.67 vs 17.71 cm 2 ) than controls and were closely associated with the mediastinum. There were more LELC tumours with well-defined borders (p<0.001) and fewer with spiculated borders (p<0001) than non-LELC tumours. There was increased peribronchovascular nodal spread (p=0.01) and vascular encasement (p=0.02) in LELC compared with non-LELC tumours. Advanced primary pulmonary LELC has distinct radiological features, and can appear as well-defined tumour closely associated with the mediastinum, with peribronchovascular spread and vascular encasement.

show abstract

Section: Introductionmentioning

confidence: 74%

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Ooi

Khong

et al. 2003

Eur Radiol

View full text Add to dashboard Cite

show abstract

“…Currently, there have been 33 case reports and/or series describing the occurrence of LELC of the lung, 1–33 which are summarized in Table 1. The patients were predominantly East Asians, and Caucasians accounted for only 18 of 153 cases.…”

Section: Epidemiologymentioning

confidence: 99%

Lymphoepithelioma‐like carcinoma of the lung

Ho¹,

Wong

Lam³

2006

Respirology

111

136

View full text Add to dashboard Cite

Lymphoepithelioma-like carcinoma of the lung HO JC, WONG MP, LAM WK. Respirology 2006; 11: 539-545 Abstract: Lymphoepithelioma-like carcinoma (LELC) of the lung was first reported in 1987. In the past two decades, there have been just more than 150 cases reported in the literature. This uncommon but distinct form of non-small cell lung carcinoma has a predilection for young non-smoking Asians, without gender distinction. Histologically, it is indistinguishable from undifferentiated nasopharyngeal carcinoma. The carcinogenic role of latent Epstein-Barr virus infection in causing LELC of the lung has been evident almost exclusively in Asians compared with Caucasians. Among the reported cases, more than half were in early resectable stages (I or II) and there was a tendency for peribronchovascular spread with vascular encasement in advanced diseases. In order to establish the diagnosis of LELC of the lung, both nasopharyngeal carcinoma and lymphoma have to be excluded by endoscopic biopsy (with or without magnetic resonance imaging of the nasopharynx) and immunohistochemical staining of the biopsy samples. The mainstay of treatment for early-stage disease is curative surgical resection, whereas multimodality treatment (surgery, chemotherapy, radiotherapy) has been adopted in advanced or metastatic diseases. The overall survival is more favourable in LELC of the lung compared with non-LELC type of non-small cell lung carcinoma. Future collaborative studies especially on optimizing treatment for this uncommon malignancy are clearly warranted.

show abstract

“…LELC of the lung has been described predominantly in Asian patients, mostly as individual case reports, with only a few small series of cases. [156][157][158][159][160][161][162][163][164] Begin and colleagues 156 are credited for the first description, in a 40-year-old female nonsmoker of Asian background with a lung tumor that histologically resembled a nasopharyngeal tumor. The immunologic profile was suggestive of EBV infection.…”

Section: Lymphoepithelioma-like Carcinomamentioning

confidence: 99%

Non–Small Cell Carcinomas of the Lung

2010

Tumors and Tumor-Like Conditions of the Lung and Pleura

View full text Add to dashboard Cite

Lymphoepithelioma‐like carcinoma of the lung

Cited by 25 publications

References 10 publications

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Lymphoepithelioma‐like carcinoma of the lung

Non–Small Cell Carcinomas of the Lung

Contact Info

Product

Resources

About