Lymphoepithelioma-like carcinoma of the breast: not Epstein-Barr virus–, but human papilloma virus–positive

Kulka, Janina; Kovalszky, Ilona; Svastics, E; Berta, Maria; Füle, Tibor

doi:10.1016/j.humpath.2007.08.006

Cited by 43 publications

(38 citation statements)

References 15 publications

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“…The presence of HPV has been shown in the LELCs of other organs, such as oral cavity, 26,27 breast, 25 and uterine cervix. 28,29 However, there are no studies to date evaluating the presence of HPV in LEL-HCCs.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

Patel

Liu

Vaccharajani

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The World Health Organization has recently recognized lymphoepithelioma-like carcinoma, or inflammatory hepatocellular carcinoma, as a variant of hepatocellular carcinoma.Objective.-To identify and characterize the inflammatory hepatocellular carcinomas in our institution from 1988 to the present.Design.-All cases of hepatocellular carcinoma in our institution from 1988 to the present were reviewed and reclassified as lymphoepithelioma-like carcinoma and were studied in comparison to appropriately matched controls.Results.-Among the 8 cases of lymphoepithelioma-like carcinoma identified, the male to female ratio was 1:3, the mean age was 68.5 years (range, 57-78 years), and all of the cases were seen in noncirrhotic livers. The average numbers of lymphocytes were significantly higher in the cases than in the controls. T cells were predominant, with a uniform distribution of CD4 and CD8 positive cells. Cholangiolar differentiation was seen by K19 positivity as focal in 1 case and diffuse in 2 cases. In situ hybridization for Epstein-Barr virus was negative in all of the cases. Diffuse overexpression of p16 (.75% of cells) was seen in 2 cases, both of which were negative for the presence of transcriptionally active human papilloma virus by in situ hybridization. In our series, 3 of 8 cases (37.5%) showed local recurrence, which was similar to the controls (6 of 18; 33%), P . .99. Although the rate of distant metastases was lower among the cases (12.5%) than the controls (22.2%), the difference was not statistically significant (P . .99).Conclusion.-We present the first series of 8 cases of lymphoepithelioma-like carcinoma of the liver occurring in patients without cirrhosis and with a female preponderance and the absence of Epstein-Barr virus. Although clinical outcomes were similar to those of controls in our small series, additional data may be required for confirmation.

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Section: Discussionmentioning

confidence: 99%

“…Human papilloma virus (HPV) DNA has been shown in the tumor cells of lymphoepitheliomas of the breast, 25 and transcriptionally active HPV has been shown by in situ hybridization in LELCs of the oropharynx. 26,27 There is controversial evidence of involvement of HPV in the uterine cervix; some authors report its presence, 28,29 whereas others do not.…”

mentioning

confidence: 99%

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

Patel

Liu

Vaccharajani

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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“…Previous studies have demonstrated the presence of HPV high-risk types 16, 18 and 33 in breast cancer specimens from diverse populations around the world: Italy, Norway, China, Japan, USA, Austria, Brazil, Australia, Taiwan, Turkey, Greece, Korea, Mexico, Hungary and Syria (Lonardo et al, 1992;Hennig et al, 1999;Yu et al, 1999;Liu et al, 2001;Damin et al, 2004;Widschwendter et al, 2004;de Villiers et al, 2005;Kan et al, 2005;Tsai et al, 2005;Gumus et al, 2006;Kroupis et al, 2006;Lawson et al, 2006;Choi et al, 2007;Akil et al, 2008;Khan et al, 2008;Kulka et al, 2008;MendizabalRuiz et al, 2009). The prevalence of HPV positive breast cancer in these studies was reported to vary from 4% in Mexican to 86% in American women.…”

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confidence: 99%

Human papilloma virus is associated with breast cancer

et al. 2009

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BACKGROUND: There is increasing evidence that high-risk human papilloma virus (HPV) is involved in cancers in addition to cervical cancer. For example, it is generally accepted that HPV has a role in a significant proportion of head and neck tumours, and it has long been hypothesised that hormone dependent oncogenic viruses, such as HPV may have causal roles in some human breast cancers. A number of reports have identified HPV DNA in breast tissue and breast cancer specimens, but these rely on standard polymerase chain reaction (PCR), which is criticised for its propensity for contamination. METHODS: We have used two different technologies, in situ and standard PCR (with sequencing), and histology based on light microscopy. RESULTS: We unambiguously demonstrate the presence of high-risk HPV in the cells of breast cancer specimens and breast cancer cell lines. In addition, we also show that the oncogenic characteristics of HPV associated breast cancer are very similar to HPV-associated cervical cancer. Specifically, that putative koilocytes are present in some HPV associated breast cancers. INTERPRETATION: The above observations indicate a likely causal role for high-risk HPV in human breast cancer and offer the possibility of primary prevention of some breast cancers by vaccination against HPV.

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“…A possible relationship of this type of the tumour with the human papilloma virus [27] has also been suggested in a patient with a previous history of cervical carcinoma in situ. In our case, HIV seropositivity was established.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Breast: Cytological and Histological Features and Review of the Literature

Trihia

Siatra²,

Gklisty³

et al. 2012

Acta Cytologica

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Objective: We present, for the first time, the cytological features of lymphoepithelioma-like carcinoma (LELC) of the breast in preoperative fine-needle aspiration (FNA) and touch imprints from secondary deposits in the sentinel lymph node (SLN). Study Design: We report a case of a 53-year-old woman who was diagnosed with breast carcinoma on preoperative FNA and was subjected to SLN biopsy, partial mastectomy and axillary lymph node dissection. The final diagnosis was LELC of the breast. Cytological and histological features were analyzed. Results: The smears from preoperative FNA contained cohesive clusters and isolated tumour cells in a haemorrhagic background with scattered lymphocytes. Some of the clusters were infiltrated by the inflammatory cells. The cells had large, pleomorphic nuclei and scanty, ill-defined cytoplasm. The intraoperative touch imprints from the SLN were highly cellular, comprising abundant scattered lymphoid cells, among which were tight clusters of indistinct cells, about 3 times larger than the lymphocyte population. Conclusion: In our case, LELC shares many cytological features with LELC described in other organs. Immunostains with epithelial markers play an important role in establishing the epithelial nature of the neoplastic cells. LELC should be borne in mind in the evaluation of breast lesions with prominent lymphoid cell infiltration. Its cytological features, as presented, could contribute to its preoperative evaluation on cytological grounds.

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Lymphoepithelioma-like carcinoma of the breast: not Epstein-Barr virus–, but human papilloma virus–positive

Cited by 43 publications

References 15 publications

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

Human papilloma virus is associated with breast cancer

Lymphoepithelioma-Like Carcinoma of the Breast: Cytological and Histological Features and Review of the Literature

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