Lymphoepithelial cyst of the parotid gland: its possible histopathogenesis based on clinicopathologic analysis of 64 cases

Wu, Lin; Cheng, Jun; Maruyama, Satoshi; Yamazaki, Manabu; Tsuneki, Masayuki; Lu, Yong; He, Zhitao; Zheng, Yage; Zhou, Zhiyu; Saku, Takashi

doi:10.1016/j.humpath.2008.10.012

Cited by 55 publications

(61 citation statements)

References 28 publications

(47 reference statements)

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“…Others researchers have advocated for an obstructive theory that assumes that ductal obstruction by lymphoid proliferation might lead to ductal dilatation that mimics a true cyst. 1,3,4,[18][19][20][21] Based on the latter theory, it is possible to elaborate on two possible mechanisms for HAART's action on BLEC. It is reported, on one hand, that HAART decreases the diffuse infiltrative lymphocytosis syndrome (DILS).…”

Section: Discussionmentioning

confidence: 99%

Comparative study of the effect of antiretroviral therapy on benign lymphoepithelial cyst of parotid glands and ranulas in HIV-positive patients

Syebele

Bütow

2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective. T h i s s tu dy ' s ai m w as to a s s e ss th e ef f e c t of h i gh l y a c ti v e an ti r e tr ov i r al d r u g s (HAART) on benign lymphoepithelial cysts (BLEC) of the parotid and ranulas.Study design. The records of 10 HIV-positive patients who presented with BLEC were reviewed, and 14 HIV-positive patients who presented with ranulas were prospectively enrolled. Patients in 2 both groups received the same combination of HAART and were clinically evaluated for the first three months. Patients with ranulas were followed up for an additional three months. A clinical reduction in the size of the lesions was considered to be a positive outcome.Results. All parotid glands with BLEC resolved within three months. No positive results were observed in ranulas during the first three months. However, some of the ranulas displayed a positive result after the initial three months of HAART. Conclusion.In contrast to BLEC, ranulas in HIV-positive patients seem to present a mixed and delayed response to HAART.Numerous publications report about HIV-related salivary gland disease (HIV-SGD). HIV-related enlargement of the parotid salivary gland, particularly benign lymphoepithelial cysts (BLEC), remains the most reported form of HIV-SGD. [1][2][3][4][5][6] Other salivary glands are affected as well 1 .However, little has been reported about ranulas as being part of HIV-related salivary gland Currently, the generally accepted standard mode of treatment for ranulas is surgical removal of the offending ipsilateral salivary gland either with or without the attached cystic lesion. [13][14][15] However, this radical surgical approach might face limitations in the current clinical presentations of some cases of ranulas in HIV-positive patients. Current cases seem to include more cases of plunging and bilateral ranulas (Fig. 1). More importantly, there are reported cases of BLEC co-existing with ranulas in the same subject and in multiple sites (Fig. 1A). This c l i n i c a l p r e s e n t a t i o n o f b o t h p a t h o l o g i e s i s o f g r e a t e t i o l o g i c a l i m p o r t a n c e a n d p r e s e n t s therapeutic implications in the context of HIV-SGD. The quest for a less invasive modality of 4 treatment for ranulas in HIV-positive patients might, therefore, become a greater challenge. To date, there is no evidence-based proof of treatment for ranulas with HAART. 12 The welldocumented benefit of HAART for BLEC in HIV-positive patients has led these authors to hypothesize that the very same drugs may positively affect ranulas in the context of HIV-SGD. A comparative approach has not been performed before.The aim of this study is, therefore, to assess how ranulas in HIV-positive patients respond to HAART, and compare the results with those of BLEC in parotid salivary glands in the context of HIV-SGD. Furthermore, a secondary objective is to define the time-frame within which to assess the effectiveness of the therapy in both groups. PATIENTS AND METHODSThis was a clinical study with both retrospective an...

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Section: Discussionmentioning

confidence: 99%

Comparative study of the effect of antiretroviral therapy on benign lymphoepithelial cyst of parotid glands and ranulas in HIV-positive patients

Syebele

Bütow

2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…3 There have been numerous case reports of this entity in the head and neck region occurring predominantly on the lateral aspect of the neck (branchial cleft cyst) and the parotid gland. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 There is controversy regarding the pathogenesis of these lesions; however, enclavement of epithelium within lymph nodes is a well-known phenomenon, especially in the parotid glands and the lateral cervical region.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of a Vallecular Cyst and Literature Review

Hoang

Kim

2015

Journal of Oral and Maxillofacial Surgery

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“…The findings in our case lend support for this notion. Wu et al [11] studied 64 cases of lymphoepithelial cyst in HIV-negative patients and noted dysplastic changes in the squamous epithelial lining in two cases of their series. We also noticed that some of the squamous cells lining the cyst exhibit dysplastic changes in our case.…”

Section: Proposed Histogenesismentioning

confidence: 99%

Squamous Cell Carcinoma of Parotid Gland Associated with Concurrent Lymphoepithelial Cysts and Lymphoepithelial Lesion: Case Report and Proposed Histogenesis

Zhou

Holsinger

2014

Head and Neck Pathol

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Lymphoepithelial cyst and lymphoepithelial lesion have similar histologic features and an affinity for the parotid gland. Though considered as different entities, both conditions arise from heterotopic salivary epithelial rests or inclusions in intra-or peri-parotid lymph nodes. We present a case of squamous cell carcinoma of parotid gland associated with concurrent lymphoepithelial cyst and lymphoepithelial lesion in a patient who was not infected with human immunodeficiency virus. We propose that lymphoepithelial cyst and lymphoepithelial lesion have a similar histogenesis.

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Lymphoepithelial cyst of the parotid gland: its possible histopathogenesis based on clinicopathologic analysis of 64 cases

Cited by 55 publications

References 28 publications

Comparative study of the effect of antiretroviral therapy on benign lymphoepithelial cyst of parotid glands and ranulas in HIV-positive patients

Comparative study of the effect of antiretroviral therapy on benign lymphoepithelial cyst of parotid glands and ranulas in HIV-positive patients

A Case Report of a Vallecular Cyst and Literature Review

Squamous Cell Carcinoma of Parotid Gland Associated with Concurrent Lymphoepithelial Cysts and Lymphoepithelial Lesion: Case Report and Proposed Histogenesis

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