Lymphocytic Response of Normal Individuals to Transient Hyper- and Hypoglycemia

Lazarus, Sydney S.; Volk, Bruno W.; Jacobi, Mendel; Zymaris, Michael C.

doi:10.3181/00379727-74-17929

Cited by 9 publications

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“…An increased discharge of adrenaline is a common response to stress, and it is interesting to note that the ingestion of glucose evokes other stress responses such as lymphocytopenia [Freeman & Elmadjian, 1946;Jailer, Marks & Marks, 1948;Lazarus, Volk, Jacobi & Zymaris, 1950], eosinopenia [Jordan, Last, Pitesky & Bond, 1950;Dury, 1950;Hungerland & Raming, 1951], and increased excretion of 17-ketosteroids [Abelin & Pfister, 1950], corticosteroids and uric acid [Pincus, 1949;Pincus, Hoagland, Freeman, Elmadjian & Romanoff, 1949]. Unfor¬ tunately the effect of fructose on these reactions does not seem to have received any attention.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Glucose and Fructose Ingestion on the Adrenaline and Noradrenaline Levels in Human Plasma

Weil‐Malherbe¹,

Bone²

1954

Journal of Endocrinology

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1. The ingestion of 50 g glucose by fasting subjects led to an increase of the concentration of adrenaline in venous plasma amounting to a mean value of 55% after 10 min. The effect was almost as marked 5 min after the glucose meal when the mean blood sugar level had only gone up by 3%. During the period 10-60 min after the glucose meal the concentration of adrenaline in the plasma gradually returned to its initial value.2. The concentration of noradrenaline in the plasma was not significantly changed after a glucose meal.3. The ingestion of 50 g fructose by fasting subjects was without effect on the concentration of adrenaline or noradrenaline in the plasma. 4. A glucose meal given 15 min before an intravenous injection of insulin slightly modified the effect of insulin on the concentration of adrenaline by delaying its initial fall and also its subsequent recovery.It is suggested that the rise in the level of adrenaline after a glucose meal is caused by a decrease in the hepatic utilization of the hormone.It has been shown [Weil-Malherbe & Bone, 1954] that the administration of glucose during hypoglycaemic coma leads to a rise in the level of adrenahne in the plasma. The curve rapidly reaches a peak concentration from which it falls to a level inter¬ mediate between the concentration maintained during hypoglycaemia and that reached at the height of the reaction. It was of interest to find out whether this effect of glucose was confined to the hypoglycaemic state and whether it was shared by other monosaccharides. MATERIALS AND METHODSGlucose or fructose was given by mouth to fasting subjects and the concentration of adrenaline in the plasma determined at intervals. The subjects received a solution containing 50 g of the sugar in about 200 ml. which they were asked to drink quickly. Venous blood samples were collected before the test and 5, 10, 20, 30, 40 and 60 min after the the solution had been taken.The subjects were patients of this hospital. None of them was known to suffer from any physical disabihty or was severely or chronically disturbed mentally. Only recently admitted, co-operative cases were chosen for investigation.The analytical methods used were the same as those given in the preceding paper [Weil-Malherbe & Bone, 1954].

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Section: Discussionmentioning

confidence: 99%

The Effect of Glucose and Fructose Ingestion on the Adrenaline and Noradrenaline Levels in Human Plasma

Weil‐Malherbe¹,

Bone²

1954

Journal of Endocrinology

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“…ously (3,4,6). Sarcoma 37 in contrast to the leucocyte does not behave in the same manner toward the material from Serratia since there is no demonstrable effect in tissue culture…”

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“…

ously (3,4,6). Sarcoma 37 in contrast to the leucocyte does not behave in the same manner toward the material from Serratia since there is no demonstrable effect in tissue culture

The inhibition by the material from Gram negative organisms would appear to be more complex than "negative chemotaxis" since the material is distributed throughout the medium of red cells, white cells and plasma.

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confidence: 99%

“…It a h been hypothecated that the mechanisms stimulated by hypoglycemia are located in the hypophysis, the adrenal cortex, or the sympathetic nervous system (3,4). In a previous study it was observed that insulin administered 40 normal individuals is accompanied by -a marked rise of the absolute lymphocyte count (6). I n diabetic patients, however, the extent of the rise was propontional to the degree of hypoglycemia responsiveness evidenced by the insulin tolerance test( 7 ) .…”

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confidence: 99%

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Role of Pancreas in Hypoglycemia Responsiveness and Associated Rise of Circulating Eosinophils.

Lazarus

Volk

Tui

1952

Experimental Biology and Medicine

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ously (3,4,6). Sarcoma 37 in contrast to the leucocyte does not behave in the same manner toward the material from Serratia since there is no demonstrable effect in tissue cultureThe inhibition by the material from Gram negative organisms would appear to be more complex than "negative chemotaxis" since the material is distributed throughout the medium of red cells, white cells and plasma. The zone of stimulation noted with decreasing concentrations of the material would be more in favor of a direct effect on the leucocyte. Summary. The complex carbohydrate from S. t~p l z o s a , P . acruginos~, and Serratia as well as a filtrate from S . intercellularis inhibited the migration of human leucocytes. The same effect was noted with whole bacteria of S. typhosa and P. atwginosa. S o inhibition (7,8). was seen with M. aweus, D . pnerrtnoniae Type I11 or with the polysaccharide of Type 111. Front the J t z i s h Sanitaritcmi a n d Hospital for Chronic Diseases, Brooklyn, S . I-., a n d the Crtrdriroor Inslilttlc of Psychobiologic Studies, Queens Village, .V. 1..

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Krankheiten des Kohlenhydratstoffwechsels

Gräfe¹,

Kühnau²

1955

Innersekretorische Und Stoffwechsel-Krankheiten

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Lymphocytic Response of Normal Individuals to Transient Hyper- and Hypoglycemia

Cited by 9 publications

References 0 publications

The Effect of Glucose and Fructose Ingestion on the Adrenaline and Noradrenaline Levels in Human Plasma

The Effect of Glucose and Fructose Ingestion on the Adrenaline and Noradrenaline Levels in Human Plasma

Role of Pancreas in Hypoglycemia Responsiveness and Associated Rise of Circulating Eosinophils.

Krankheiten des Kohlenhydratstoffwechsels

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