Lymphocytic infiltration surrounding liver metastases from colorectal cancer

Okano, Keiichi; Mizutani, Takashi; Moroguchi, Akito; Ishimura, Kimihiko; Karasawa, Yukihiko; Izuishi, Kunihiko; Goda, Fuminori; Usuki, Hisashi; Wakabayashi, Hisao; Maeta, Hajime

doi:10.1002/jso.10188

Cited by 65 publications

(49 citation statements)

References 37 publications

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“…10 Similarly, tumour lymphocytic infiltration was shown to independently predict patient outcome in patients with CLM. 48 The prognostic value of lymphocytes does not appear to be reflected at the systemic level, however, as whilst the number of tumourinfiltrating CD8+ T-lymphocytes was found to correlate with patient outcome in primary CRC, the number of these cells in the systemic circulation showed no correlation with prognosis. 49,50 Similarly, a recent study found no correlation between total circulating lymphocyte count and outcome in patients with either operable primary CRC or unresectable CLM.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases

Neal¹,

Mann²,

Sutton³

et al. 2009

European Journal of Cancer

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Background: There is increasing evidence that the presence of a preoperative systemic inflammatory response (SIR) independently predicts poor long-term outcome in patients with colorectal cancer (CRC).Socioeconomic deprivation was reported to correlate with the presence of the SIR and to itself independently predict poor outcome following primary CRC resection. The aim of this study was to determine the prognostic value of preoperative systemic inflammatory biomarkers and socioeconomic deprivation in patients undergoing resection of colorectal liver metastases (CLM) and to examine correlations between these variables in this context. Results: On multivariable analysis, poor CRS (3-5), high neutrophil count (>6.0 x10 9 /L) and low serum albumin (<40 g/dL) were the only independent predictors of shortened overall survival following metastasectomy, with neutrophil count representing the greatest relative risk of death. These factors were also the only independent predictors of shortened disease-free survival 3 following hepatectomy. Socioeconomic deprivation was associated with neither systemic inflammation nor long-term outcome in this context. Patients and methods: Conclusions:The presence of a preoperative systemic inflammatory response, but not socioeconomic deprivation, independently predicts shortened survival following resection of CLM.4

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Section: Discussionmentioning

confidence: 96%

Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases

Neal¹,

Mann²,

Sutton³

et al. 2009

European Journal of Cancer

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“…Una linfocitopenia relativa podría afectar el pronóstico. En la misma línea, algunos estudios han demostrado que los pacientes con menos infiltrados linfocitarios en los márgenes tumorales tienen peor pronóstico [23][24][25][26] y, según el sistema de etapificación de Jass 27 , un mayor infiltrado linfocitario en el tumor está asociado a una mejor chance de sobrevida. Otros estudios han validado el hecho que un tumor tenga mayor infiltrado inflamatorio, principalmente compuesto por linfocitos, se correlaciona con mejor pronóstico 28,29 .…”

Section: Discussionunclassified

Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cancer de colon etapa II resecado

Urrejola¹,

Bambs²,

Espinoza³

et al. 2013

Rev. méd. Chile

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“…Host immune response plays a role in the evolution of tumour growth. An impaired host immune response, evidenced by a weak lymphocyte infiltration at tumour margin, is associated with a poor prognosis in patients who had liver resection for CRLM (Okano et al, 2003). There is an inverse relationship between CRP levels and tumour lymphocyte infiltration, with a raised CRP concentration indicative of a weak infiltration of lymphocytes at the periphery of the tumour (Canna et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

et al. 2007

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There is increasing evidence that systemic inflammatory response has a positive correlation with a poorer outcome in patients undergoing resection for solid tumours. The aim of this study was to analyse the impact of an elevated C-reactive protein (CRP), an outcome following curative resection for colorectal liver metastases. One hundred and seventy patients who underwent curative resection for colorectal liver metastases were included in the study. Laboratory measurements of haemoglobin, white cell, platelets, albumin and CRP were taken on the day before surgery. Elevated CRP (410 mg l À1 ) was present in 54 (31.8%) patients. The median survival of patients with an elevated CRP was 19 months (95% CI 7.5 -31.2 months) compared to 42.8 months (95% CI 33.2 -52.5 months) for those with a normal CRP, P ¼ 0.004. Similarly, when assessing disease-free survival, patients with an elevated CRP had poorer disease-free survival (median of 11.8 months (95% CI 6.4 -17.3) compared to median of 15.1 months (95% CI 11.1 -19.1)), P ¼ 0.043. The result of the study showed that an elevated preoperative CRP is a predictor of poor outcome in patients undergoing curative resection for colorectal liver metastases.

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Lymphocytic infiltration surrounding liver metastases from colorectal cancer

Abstract: The extent of lymphocytic infiltration between the metastatic nodule and hepatic parenchyma may reflect host defensive activity in the liver and is closely related to prognosis in patients who underwent hepatic resection for liver metastases from colorectal cancer.

Cited by 65 publications

References 37 publications

Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases

Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases

Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cancer de colon etapa II resecado

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

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