Lymphocytic hypophysitis in the elderly

Sellayah, Renishka; Gonzales, Michael; Fourlanos, Spiros; King, James

doi:10.1016/j.jocn.2015.03.051

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Autoimmune hypophysitis is a disorder with a strong temporal relationship to pregnancy where there is lymphocytic infiltration of the pituitary gland and infundibulum frequently leading to hypopituitarism, diabetes insipidus or hyperprolactinemia. Our patient did not match the classical clinical picture of autoimmune hypophysitis (young peripartum females presenting with pituitary dysfunction), although there are case reports in the literature of males and elderly patients presenting with autoimmune hypophysitis [3]. Additionally, our patient had a cystic component on MRI, which is radiographically inconsistent with autoimmune hypophysitis and he lacked enhancement of the anterior pituitary and stalk thickening which is thought to be specific for lymphocytic hypophysitis.…”

Section: Discussionmentioning

confidence: 55%

Vanishing Pituitary Macroadenoma: A Case Report

Sieg

Stepanyan

Payne

et al. 2016

Cureus

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Pituitary macroadenomas are the most common suprasellar lesions in adults and are typically managed surgically through transsphenoidal resection when symptomatic. Due to their close proximity to the optic chiasm, pituitary macroadenomas often present with signs of bitemporal hemianopsia. Alternatively, these tumors can cause mass effect, thus presenting with signs of elevated intracranial pressure or can present with signs and symptoms of endocrine dysfunction. Here, we discuss a 55-year-old male diagnosed with a non-functioning pituitary macroadenoma (NFPA) based on cranial imaging, ophthalmologic exam, and endocrine evaluation. Following diagnosis, the patient was scheduled for transsphenoidal hypophysectomy. On magnetic resonance imaging (MRI) done three and half months later for surgical planning, the tumor had almost completely regressed and only residual pituitary tissue was noted. We describe the presentation and clinical course of the patient, summarize chief differential diagnoses, and discuss potential managements of these conditions.

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Section: Discussionmentioning

confidence: 55%

Vanishing Pituitary Macroadenoma: A Case Report

Sieg

Stepanyan

Payne

et al. 2016

Cureus

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“…However, cases occurring outside pregnancy have been on the increase in the recent years [3][4][5]21]. The mean age at diagnosis is usually 35 ± 13 years for women and 45 ± 14 years for men [1][2][3], but some cases have been described in children [25] and in the elderly [26]. Among the ethnic factors, in the first series of patients the Caucasian to Japanese ratio was about 3:1 [2] but a recent reevaluation by Caturegli et al [21] lowered this ratio considerably with increased cases of Japaneses affected, even if still inferior to Caucasians in percentage.…”

Section: Epidemiologymentioning

confidence: 99%

Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects

et al. 2016

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Autoimmune hypophysitis is a multifaceted disease, which may certainly be diagnosed by pituitary biopsy. However, the possible different clinical, laboratory and imaging features must be considered by the physician to avoid a misdiagnosis when examining a possibly affected patient. Therapeutic choice has to be made taking into account the clinical conditions and the degree of hypothalamic-pituitary involvement, but also considering that spontaneous remissions can occur.

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