Lymphocytic gastritis—relationship to <i>Campylobacter pylori</i> infection

Dixon, M. F.; Wyatt, J I; Burke, Dave; Rathbone, B. J.

doi:10.1002/path.1711540204

Cited by 184 publications

(65 citation statements)

References 15 publications

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“…The controversy between the negative histology and positive serology for H pylori in LG in the present and previous studies [5,6,13] might be explained by the fact that the bacteria are present in very small numbers, which could make them impossible to detect. In the present study, even the patients histologically positive for H pylori showed only a small amount of bacteria.…”

Section: Discussioncontrasting

confidence: 67%

“…The reported prevalence of LG among patients with dyspepsia varies between 1-8 % [4,5] . Most dyspeptic patients with LG are seropositive for Helicobacter pylori, indicating that LG may represent an atypical host immune response to the infection [6] . Cases associated with H pylori infection have been reported to respond to H pylori eradication treatment [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

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Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect ofH pyloritreatment

Mäkinen

Niemelä²,

Kerola³

et al. 2003

WJG

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AIM: Lymphocytic gastritis is commonly associated withHelicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation, forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis, and to evaluate the effect of H pylori treatment.

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Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect ofH pyloritreatment

Mäkinen

Niemelä²,

Kerola³

et al. 2003

WJG

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“…It is an uncommon condition that is present in 0.83% of unselected gastric biopsies (79) and in 1.7-4.5% of inflamed gastric biopsies (85,86). The essential diagnostic feature is the presence of increased mucosal lymphocytes in the lamina propria, as well as in the surface and foveolar epithelium.…”

Section: Lymphocytic Gastritismentioning

confidence: 99%

Gastritis and Carditis

Owen

2003

Modern Pathology

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Dyspepsia is a common clinical problem. Its causes include peptic ulcer disease, gastroesophageal reflux, and functional (nonulcer) dyspepsia. A detailed clinical description of pain does not reliably differentiate the cause. Approximately 80% of gastroscopies are performed for the investigation of dyspepsia. "Gastritis" is diagnosed endoscopically in 59% of all stomachs, although in only 3% are the changes severe. Pathologic examination of unselected gastric biopsy specimens reveals that abnormalities are present in 62-73%, but there is only a weak correlation between endoscopic and histologic findings. For these reasons, it is recommended that endoscopic examination should always be accompanied by biopsy. Ideally, biopsies should be taken in a systematic fashion to include sampling of antrum and corpus. Recent evidence suggests that gastric infection by Helicobacter pylori initially presents as a superficial gastritis. Later it may become atrophic with development of intestinal metaplasia. The onset of atrophic changes may be related to the duration of infection, the strain of the infecting organism, associated dietary factors, or as-yet undefined host factors related to immunity. Persistent superficial gastritis predisposes to duodenal ulcer and gastric mucosa-associated lymphoid tissue lymphoma. Atrophic gastritis predisposes to gastric ulcer and adenocarcinoma. Evidence is accumulating that in some patients, pernicious anemia may be an end result of H. pylori-induced atrophic gastritis. Reactive gastropathy is a relatively common finding in gastric biopsies; in most instances it is associated with either reflux of duodenal contents or therapy with nonsteroidal anti-inflammatory drugs. Lymphocytic gastritis, eosinophilic gastritis, and the gastritis associated with Crohn's disease are distinct morphologic entities. Most gastroscopies are performed for the investigation of dyspepsia (1-7). This is a common clinical problem but is rarely life-threatening. The causes of dyspepsia include peptic ulcer disease (30%), gastroesophageal reflux (29%), and nonulcer (functional) dyspepsia (40%). The cause of functional dyspepsia is unclear at the present time, although in many instances it may be related to abnormalities of gut motility. In Ͻ1% of cases is gastric cancer a cause of dyspepsia. A detailed description of the symptoms of dyspepsia does not reliably differentiate the cause, although the presence of heartburn strongly suggests a component of gastroesophageal reflux. Correlations among patient symptoms, endoscopic appearances, and biopsy findings of gastritis are imperfect (4 -6). Agreement is best in cases where peptic ulcer or another focal lesion is identified. A study by Khakoo et al. (7) from the United Kingdom illustrates the problems encountered. Endoscopic and histologic findings were reviewed in 167 patients who underwent gastroscopy for dyspeptic symptoms. Of these, 98 patients (57%) had endoscopic evidence of gastritis. In 42% of patients, gastritis involved the antrum alone, in 7% it involved the...

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“…The organisation and histological features of the lymphoid tissue in the GIT differs from that of peripheral lymph nodes, occurring in the form of mucosa associated lymphoid tissue (MALT) which has unique immuno-physiological characteristics. The lymphoid tissue of MALT may be a normal tissue component, as in the intestine; or it may be acquired as a consequence of an autoimmune or inflammatory disorder, as in the stomach (Isaacson et al, 1988;Dixon et al, 1988). Lymphomas of the GIT may therefore behave differently from primary nodal disease.…”

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confidence: 99%