Lymphocytic Choriomeningitis Virus Infections and Seroprevalence, Southern Iraq

Alburkat, Hussein; Jääskeläinen, Anne J.; Barakat, Ali; Hasony, Hassan J.; Sironen, Tarja; Al-Hello, Haider; Smura, Teemu; Vapalahti, Olli

doi:10.3201/eid2612.201792

Cited by 10 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall LCMV IgG seroprevalence was 8.8%. In the control group, 12.2% of participants were seropositive compared to 7% in the group of acute febrile patients [ 23 ]. Additionally, LCMV RNA was detected in 5.1% of cerebrospinal fluid samples from patients with a neuroinvasive infection in southern Iraq [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, a previously published Croatian study conducted among inhabitants of the Vir Island showed no gender difference [ 26 ]. In Argentina, significantly higher LCMV seroprevalence was found in men [ 18 , 23 ], while in Canada seroprevalence was higher in women [ 32 ]. The possible reason for this gender distribution is that women are more frequently exposed to dust contaminated with the excreta of house mice during the cleaning of the house and yard.…”

Section: Discussionmentioning

confidence: 99%

“…In one Iraqi study (2012–2013) [ 20 ], a higher seroprevalence was found in women (9.7% vs. 3.5%), while in another one (2012–2016), men were more often seropositive compared to women (7.9% vs. 5.6%). However, in patients with acute febrile illness, the gender ratio was reversed (3.9% in women, 2.8% in men) [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Seroepidemiological studies revealed that up to 15% of the population is LCMV seropositive [ 17 , 18 , 19 , 20 , 21 , 22 ]. While some studies showed higher seroprevalence rates in specific population groups such as forestry workers or hunters, others did not find differences in the seropositivity between persons professionally exposed to rodents and the general population [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

et al. 2021

View full text Add to dashboard Cite

Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce. We analyzed the seroprevalence of LCMV in continental Croatian regions. A total of 338 serum samples of professionally exposed (forestry workers, hunters, agriculture workers in contact with rodents) and non-exposed populations (general population, pregnant women) were tested for the presence of LCMV antibodies using indirect immunofluorescence assay. No participants reported recent febrile disease. LCMV IgG antibodies were detected in 23/6.8% of participants: 9.8% exposed persons and 5.1% non-exposed persons (6.1% in the general population and 3.9% in pregnant women). No participants were LCMV IgM positive. Although higher seropositivity was found in males compared to females (8.9% vs. 4.7%), inhabitants of suburban/rural areas compared to inhabitants of urban areas (9.2% vs. 4.6%), and persons who used well as a source of water compared to those who used tap (11.4% vs. 5.6%), these differences did not reach statistical significance. Results of logistic regression showed that the presence of rodents in the house/yard and cleaning rodent nests were associated with an elevated risk for LCMV infection (OR = 2.962, 95% CI = 1.019–8.607).

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The seroprevalence was 12.2% in the healthy control group and 7% in the acute febrile patients. Moreover, two CSF samples from patients with fever and neurologic symptoms were positive for LCMV RNA [26].…”

Section: Lcmv Prevalence In Humansmentioning

confidence: 99%

Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review

et al. 2021

View full text Add to dashboard Cite

Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne zoonotic virus distributed worldwide. Since serologic assays are limited to several laboratories, the disease has been underreported, often making it difficult to determine incidence and seroprevalence rates. Although human clinical cases are rarely recorded, LCMV remains an important cause of meningitis in humans. In addition, a fatal donor-derived LCMV infection in several clusters of solid organ transplant recipients further highlighted a pathogenic potential and clinical significance of this virus. In the transplant populations, abnormalities of the central nervous system were also found, but were overshadowed by the systemic illness resembling the Lassa hemorrhagic fever. LCMV is also an emerging fetal teratogen. Hydrocephalus, periventricular calcifications and chorioretinitis are the predominant characteristics of congenital LCMV infection, occurring in 87.5% of cases. Mortality in congenitally infected children is about 35%, while 70% of them show long-term neurologic sequelae. Clinicians should be aware of the risks posed by LCMV and should consider the virus in the differential diagnosis of aseptic meningitis, especially in patients who reported contact with rodents. Furthermore, LCMV should be considered in infants and children with unexplained hydrocephalus, intracerebral calcifications and chorioretinitis. Despite intensive interdisciplinary research efforts, efficient antiviral therapy for LCMV infection is still not available.

show abstract

A case report of human infection with lymphocytic choriomeningitis virus in Israel

Grupel

Lustig

Brosh‐Nissimov

2022

Journal of Medical Virology

View full text Add to dashboard Cite

Lymphocytic choriomeningitis virus (LCMV) is an often‐overlooked cause for viral meningitis but can have severe consequences in certain clinical situations. We present the first documented infection by LCMV in Israel. The epidemiology of LCMV is evolving with a potential for a worldwide endemicity due to the widespread presence of the natural host. Increased awareness and testing are required to identify this virus and screening of certain populations (e.g., organ donors) should be considered.

show abstract

Lymphocytic Choriomeningitis Virus Infections and Seroprevalence, Southern Iraq

Cited by 10 publications

References 14 publications

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review

A case report of human infection with lymphocytic choriomeningitis virus in Israel

Contact Info

Product

Resources

About