Lymphocyte Transformation and Changes in Leukocyte Count

Cullen, Bruce F.; Belle, Gerald van

doi:10.1097/00000542-197511000-00014

Cited by 113 publications

(41 citation statements)

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“…An increase in both total number of leucocytes and neutrophils was also observed in other studies [29,30]. This increase is evident at the end of surgery and lasts several days.…”

Section: Leucocyte Countsupporting

confidence: 86%

Effect of general anaesthesia and surgery on neutrophil function

et al. 1995

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“…An increase in both total number of leucocytes and neutrophils was also observed in other studies [29,30]. This increase is evident at the end of surgery and lasts several days.…”

Section: Leucocyte Countsupporting

confidence: 86%

Effect of general anaesthesia and surgery on neutrophil function

et al. 1995

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“…Despite the uncomplicated perioperative courses, leukocytosis and neutrophilia are generally encountered after CPB. 6,7 However, the complex mechanisms and mediators are not well understood. One may speculate that increased concentrations of G-CSF contributed to post-CPB leukocytosis.…”

Section: Discussionmentioning

confidence: 99%

Neutrophilia and granulocyte colony-stimulating factor levels after cardiopulmonary bypass

Iwasaka

Kitano

Miyakawa

et al. 2001

Can J Anesth/J Can Anesth

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Purpose: The precise mechanism of neutrophilia after cardiac surgery is unknown. Granulocyte colony stimulating factor (G-CSF) can increase the number of leukocytes. The purpose of this study was to evaluate the relationship between serum G-CSF levels and peripheral blood leukocyte counts after cardiac surgery. Methods:We prospectively studied 10 patients undergoing cardiac surgery (coronary artery bypass grafting) using cardiopulmonary bypass (CPB). Plasma G-CSF levels and neutrophil count were measured before induction of anaesthesia, at the end of surgery, and on the first postoperative day. These changes were compared with those in patients undergoing non-cardiac major surgery (control group).Results: At the end of surgery, G-CSF levels increased (P < 0.01) in both groups, but were higher in the control than in the cardiac group (3,250 ± 690 vs 194 ± 29.5 pg·ml -1 , respectively, mean ± SEM, P < 0.01). On the first postoperative day, G-CSF levels were still high in both groups, and were still higher in the control (710 ± 179 vs 122 ± 19.9, respectively, P < 0.01). However, neutrophilia was greater in the cardiac group than in the control. G-CSF response correlated positively with neutrophilia in the control group (r=0.656, P < 0.05) but not in the cardiac group. Conclusions:Our results indicate that changes in leukocyte count following cardiac surgery are unique to patients undergoing CPB. G-CSF plays an important role as the mediator of neutrophilia after non-cardiac surgery, but not after cardiac surgery with CPB.Objectif : Le mécanisme précis de la polynucléose neutrophile qui survient après une intervention en cardiochirurgie est inconnu. Le facteur stimulant la formation de colonies de granulocytes (FSC-G) peut augmenter le nombre de leucocytes. L'objectif de la présente étude était d'évaluer la relation entre les niveaux sériques de FSC-G et la numération leucocytaire du sang périphérique à la suite d'une intervention cardiaque.Méthode : Nous avons mené une étude prospective auprès de 10 patients qui ont subi un pontage aorto-coronarien sous circulation extracorporelle (CEC). Les niveaux plasmatiques de FSC-G et la numération des neutrophiles ont été mesurés avant l'induction de l'anesthésie, à la fin de l'opération et au premier jour postopératoire. Les changements ont été comparés avec ceux qu'on a observés chez des patients qui ont subi une intervention importante, non cardiaque (groupe témoin).Résultats : À la fin de l'opération, les niveaux de FSC-G ont augmenté (P < 0,01) dans les deux groupes, mais ont été plus élevés dans le groupe témoin que dans le groupe de cardiochirurgie (3,250 ± 690 vs 194 ± 29,5 pg·ml -1 , respectivement, moyenne ± écart type, P < 0,01). Au premier jour postopératoire, les niveaux de FSC-G étaient encore élevés dans les deux groupes et toujours plus hauts chez les témoins (710 ± 179 vs 122 ± 19,9, respectivement, P < 0,01). Toutefois, la polynucléose neutrophile était plus marquée dans le groupe de cardiochirurgie que dans le groupe témoin. La réponse du FSC-G était en...

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“…In human surgical patients there are many data that confirm the postoperative depression of lymphocyte function. The degree of postsurgical inhibition of lymphocytic proliferation was reported to be proportional to the se-Acta Veterinaria Hungarica 51, 2003 verity of the surgery (Berenbaum et al, 1973;Cullen and Van Belle, 1975;Salo, 1978). Depressed lymphocyte transformation was found in association with major surgical stress but not in association with anaesthesia alone before surgery (Eskola et al, 1984), as well as during minimally stressful surgical procedures using inhalation halothane anaesthesia (Mattila-Vuori et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Surgical stress and anaesthetic agents can induce alteration of various aspects of polymorphonuclear leukocyte and lymphocyte functions. Postoperative immunosuppression is well documented in the human population (Cullen and Van Belle, 1975;Tonnesen and Wahlgreen, 1988;Nishina et al, 1999). The depression of cell-mediated immunity can develop in various degrees and is usually dependent on the kind of anaesthetic, its dose and on the extent of surgical trauma.…”

mentioning

confidence: 99%

Effect of ovariohysterectomy on canine postsurgical leukocyte function

Mojžišová

Hromada

Valocký

et al. 2003

Acta Veterinaria Hungarica

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The effect of surgery on phagocytic activity of blood leukocytes and mitogen-induced blastogenesis of lymphocytes was studied in fourteen dogs. Simple ovariohysterectomy with anaesthesia induced by ketamine and xylazine or by ketamine, xylazine and halothane caused a short nonsignificant depression of phagocytic activity that persisted for four hours after surgery. Ingestion capacity of leukocytes decreased significantly immediately after surgery. Mitogen-induced blastogenesis of lymphocytes was depressed significantly in the first 48 hours and despite partial recovery this parameter did not reach the value of the control groups until the end of observation (7 days). A more conspicuous decrease of blastogenic response of blood lymphocytes to mitogens was found after the use of ketamine and xylazine in a dose maintaining anaesthesia. Anaesthesia with ketamine and xylazine in the lower dose and maintained with halothane resulted in a later improvement of the blastogenic response of lymphocytes.

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Lymphocyte Transformation and Changes in Leukocyte Count

Cited by 113 publications

References 0 publications

Effect of general anaesthesia and surgery on neutrophil function

Effect of general anaesthesia and surgery on neutrophil function

Neutrophilia and granulocyte colony-stimulating factor levels after cardiopulmonary bypass

Effect of ovariohysterectomy on canine postsurgical leukocyte function

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