Lymphocyte-to-Monocyte Ratio and Clinical Outcomes in Cholangiocarcinoma: A Systematic Review and Meta-Analysis

Dotto-Vasquez, Giuseppe; Villacorta-Ampuero, Andrea K.; Ulloque-Badaracco, Juan R.; Hernández-Bustamante, Enrique A.; Alarcón-Braga, Esteban A.; Herrera-Añazco, Percy; Benítes-Zapata, Vicente A.; Hernandez, Adrián V.

doi:10.3390/diagnostics12112655

Cited by 5 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gao and colleagues revealed that a low LMR was associated with poor OS and reduced DFS/PFS in nasopharyngeal carcinoma through a meta-analysis involving 3773 patients [ 46 ]. Dotto-Vasquez et al performed a meta-analysis including 19 studies and indicated that cholangiocarcinoma patients with low values of LMR were associated with worse OS and poor time to recurrence (TTR) [ 47 ]. In a recent meta-analysis comprising 8361 cases, it was reported that decreased pretreatment LMR was significantly correlated with reduced PFS and worse OS in lung cancer [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis

Wang,

Xu,

Zhang

2023

BMC Med

View full text Add to dashboard Cite

Background Many studies have explored the prognostic role of the lymphocyte-to-monocyte ratio (LMR) in patients with glioma, but the results have been inconsistent. We therefore conducted the current meta-analysis to identify the accurate prognostic effect of LMR in glioma. Methods The electronic databases of PubMed, Web of Science, Embase, and Cochrane Library were thoroughly searched from inception to July 25, 2023. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the prognostic role of LMR for glioma. Results A total of 16 studies comprising 3,407 patients were included in this meta-analysis. A low LMR was significantly associated with worse overall survival (OS) (HR = 1.35, 95% CI = 1.13–1.61, p = 0.001) in glioma. However, there was no significant correlation between LMR and progression-free survival (PFS) (HR = 1.20, 95% CI = 0.75–1.91, p = 0.442) in glioma patients. Subgroup analysis indicated that a low LMR was significantly associated with inferior OS and PFS in glioma when using a cutoff value of ≤ 3.7 or when patients received mixed treatment. Conclusions This meta-analysis demonstrated that a low LMR was significantly associated with poor OS in glioma. There was no significant correlation between LMR and PFS in glioma patients. The LMR could be a promising and cost-effective prognostic biomarker in patients with glioma in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis

Wang,

Xu,

Zhang

2023

BMC Med

View full text Add to dashboard Cite

show abstract

“…In the progression of malignancy, it influences the cellular components of the immune system, and its chronic state stimulates immunity and is associated with a poor prognosis [28,29]. In this sense, several studies have demonstrated the importance of some inflammatory markers in the prognosis of cancer patients, such as the lymphocyte/monocyte ratio, which is a prognostic indicator in head and neck cancer [30], rectal cancer [31], ovarian cancer [32] and cholangiocarcinoma [33]. We also have the NLR, which is a prognostic indicator in melanoma [34], endometrial cancer [35], or solid tumors [36].…”

Section: Discussionmentioning

confidence: 99%

Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis

et al. 2023

Self Cite

View full text Add to dashboard Cite

The systemic immune-inflammation index (SIII) is a marker studied in multiple types of urologic cancer. This systematic review evaluates the association between SIII values with overall survival (OS) and progression-free survival (PFS) in testicular cancer. We searched observational studies in five databases. The quantitative synthesis was performed using a random-effects model. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The only measure of the effect was the hazard ratio (HR). A sensitivity analysis was performed according to the risk of bias in the studies. There were 833 participants in a total of 6 cohorts. We found that high SIII values were associated with worse OS (HR = 3.28; 95% CI 1.3–8.9; p < 0.001; I2 = 78) and PFS (HR = 3.9; 95% CI 2.53–6.02; p < 0.001; I2 = 0). No indication of small study effects was found in the association between SIII values and OS (p = 0.5301). High SIII values were associated with worse OS and PFS. However, further primary studies are suggested to enhance the effect of this marker in different outcomes of testicular cancer patients.

show abstract

A Novel Bifidobacterium/Klebsiella Ratio in Characterization Analysis of the Gut and Bile Microbiota of CCA Patients

Zhang,

Zhu,

Zhang

et al. 2023

Microb Ecol

View full text Add to dashboard Cite

Cholangiocarcinoma (CCA) is a serious health problem worldwide. The gut and bile microbiota have not been clearly characterized in patients with CCA, and better noninvasive diagnostic approaches for CCA need to be established. The aim of this study was to investigate the characteristics of the gut and bile microbiota in CCA patients. Forty-two CCA patients and 16 healthy normal controls (HNCs) were enrolled. DNA was extracted from fecal and bile samples and subjected to 16S rRNA gene analysis. We found that there were significant differences in the species diversity, structure, and composition of the microbial communities between the CCA group and the HNC grouAt the phylum level, compared with that in the HNC group, the relative abundance of Firmicutes and Actinobacteriota was significantly decreased in the CCA group, whereas Proteobacteria and Bacteroidota were significantly enriched. The Firmicutes/Bacteroidota (F/B) ratio significantly decreased in the CCA group compared to the HNC grouThe relative abundance of Klebsiella in the CCA group was significantly higher than that in the HNC group, while the relative abundance of Bifidobacterium was significantly decreased. The Bifidobacterium/Klebsiella (B/K) ratio was established as a novel biomarker and was found to be significantly decreased in the CCA group compared with the HNC grouOur findings provide evidence supporting the use of Klebsiella and Bifidobacterium as noninvasive intestinal microbiomarkers for improving the diagnosis of CCA.

show abstract

Lymphocyte-to-Monocyte Ratio and Clinical Outcomes in Cholangiocarcinoma: A Systematic Review and Meta-Analysis

Cited by 5 publications

References 49 publications

Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis

Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis

Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis

A Novel Bifidobacterium/Klebsiella Ratio in Characterization Analysis of the Gut and Bile Microbiota of CCA Patients

Contact Info

Product

Resources

About