Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes.

Mackay, Charles R.; Kimpton, Wayne G.; Brandon, Malcolm R.; Cahill, Ross N. P.

doi:10.1084/jem.167.6.1755

Cited by 160 publications

(92 citation statements)

References 19 publications

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“…retransfusion [74]. Naïve and memory lymphocytes were analysed in sheep and their tissue specific immigration was obvious [41][42][43]. Based on these experiments, the concept about naïve and memory T cells was clarified.…”

Section: Important Intestine-related Lymphocyte Migration Studies In mentioning

confidence: 99%

“…The most important one seems to be α4β7-integrin, which interacts with MAdCAM-1 (mucosal cell adhesion molecule) on endothelial cells. Expression of α4β7-integrin has been demonstrated on memory T cells of sheep which migrate through intestinal lymph nodes and PP [41]. Likewise, high levels of α4β7-integrin were detected on lymphocytes in ovine intestinal lymph, whereas expression in peripheral or pulmonary lymph was low [1,42].…”

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

“…Likewise, high levels of α4β7-integrin were detected on lymphocytes in ovine intestinal lymph, whereas expression in peripheral or pulmonary lymph was low [1,42]. MAdCAM-1 was detected at high levels on HEV of mesenteric lymph nodes and PP as well as on postcapillary venules of the intestinal lamina propria, whilst tonsils and peripheral lymph nodes were only weakly positive [41,66]. In contrast to MAdCAM-1, L-selectin preferentially directs the migration of lymphocytes into peripheral lymph nodes [15].…”

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

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Lymphocyte migration studies

Bimczok

Rothkötter

2006

Vet. Res.

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-For maintenance of immunity and tolerance, the organs and tissues of the organism are connected by migrating lymphoid cells. Understanding lymphocyte migration is essential for many disorders and diseases -especially in the mucosa-lined organs. Detailed analyses of migrating lymphocytes have been performed in many species, especially in laboratory animals. However, important experiments in lymphocyte migration have been carried out in large animals, for example sheep, cattle and pigs. These species allow experimental procedures like in situ-organ labelling, lymphocyte retransfusion studies or lymph vessel cannulations. Such studies have made an important contribution to the understanding of the overall principles of lymphocyte migration especially in the mucosal immune system. Major results on the specific migration of naïve and memory T cells through lymphoid organs, the re-distribution of γ/δ T cells in the intestinal immune system and the emigration of newly produced B cells from the ileal Peyer's patches have been obtained in large animals. Since there are growing numbers of markers for large animals, and molecular biology methods are available in these species, experiments in large animals will be an essential tool for the understanding of lymphocyte migration especially in mucosal organs.

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Section: Important Intestine-related Lymphocyte Migration Studies In mentioning

confidence: 99%

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

Section: Regulation Of Lymphocyte Migrationmentioning

confidence: 99%

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Lymphocyte migration studies

Bimczok

Rothkötter

2006

Vet. Res.

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“…Although ␥␦-T cells are a significant component of ruminant peripheral blood, afferent lymph (draining nonlymphoid tissues), and efferent lymph (draining lymph nodes), they are only a minor population within lymph nodes (11). This, as well as the observation that they form a major lymphoid population within epithelial tissues, has led investigators to suggest that ␥␦-T cells recirculate preferentially through nonlymphoid tissues like skin and gut (2).…”

mentioning

confidence: 99%

Subset-Specific Regulation of the Lymphatic Exit of Recirculating Lymphocytes In Vivo

Young¹,

Marston²,

Dudler³

2000

The Journal of Immunology

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The blood-to-lymph recirculation of lymphocytes is required for the maintenance of immune surveillance and the dissemination of memory. Although the ability of lymph-borne cells to recirculate has been well documented, relatively less is known about the migration capacity of PBLs. We have found a clear preference for PBLs to recirculate through s.c. rather than intestinal lymph nodes. This preference could be directly attributed to the migratory characteristics of γδ-T cells. γδ-T cells were found to express significantly higher levels of L-selectin than other subsets, suggesting that at least some of this preferential migration could be attributed to their interaction with ligands on vascular endothelium. More detailed experiments showed that γδ-T cells migrated through lymph nodes with greater efficiency than αβ T cells or B cells, which clearly indicated an enhanced ability of γδ-T cells to exit lymph nodes in the efferent lymph independent of entry from the blood. This hypothesis was supported by histological examination, where γδ-T cells were found almost exclusively in the interfollicular traffic areas within lymph nodes. These data indicate that γδ-T cells are the most active recirculating lymphocyte subset in ruminants and suggest new mechanisms to regulate the traffic of lymphocyte subsets through normal lymph nodes.

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“…In addition, native antigen-loaded DC could encounter B cells that enter the lymph node by HEV and activate them (Qi et al 2006). Other cell types are also transported by aVerent vessels, such as T and B lymphocytes and macrophages (Mackay et al 1988). Indeed DC, T, and B cells leave peripheral tissues and migrate towards lymph nodes owing to their expression of chemokine receptor CCR7 (Bromley et al 2005;Debes et al 2005).…”

Section: Inxammationmentioning

confidence: 99%

Developmental and pathological lymphangiogenesis: from models to human disease

Hajjami

Petrova

2008

Histochem Cell Biol

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The lymphatic vascular system, the body's second vascular system present in vertebrates, has emerged in recent years as a crucial player in normal and pathological processes. It participates in the maintenance of normal tissue Xuid balance, the immune functions of cellular and antigen traYcking and absorption of fatty acids and lipidsoluble vitamins in the gut. Recent scientiWc discoveries have highlighted the role of lymphatic system in a number of pathologic conditions, including lymphedema, inXammatory diseases, and tumor metastasis. Development of genetically modiWed animal models, identiWcation of lymphatic endothelial speciWc markers and regulators coupled with technological advances such as high-resolution imaging and genome-wide approaches have been instrumental in understanding the major steps controling growth and remodeling of lymphatic vessels. This review highlights the recent insights and developments in the Weld of lymphatic vascular biology.

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Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes.

Cited by 160 publications

References 19 publications

Lymphocyte migration studies

Lymphocyte migration studies

Subset-Specific Regulation of the Lymphatic Exit of Recirculating Lymphocytes In Vivo

Developmental and pathological lymphangiogenesis: from models to human disease

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