Lymphocyte subsets in the small intestine of piglets fed with probiotic and zinc: a qualitative and quantitative micro-anatomical study

Kalita, A.; Talukdar, Madhumita Choudhury; Sarma, Kavita; Kalita, P. C.; Barman, Nagendra Nath; Roychoudhury, P.; Kalita, Girin; Choudhary, Om Prakash; Doley, Probal Jyoti; Debroy, Swarup; Keneisenuo, K; Sarkar, Richa

doi:10.5603/fm.a2020.0148

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Pre-weaning piglet mortality ranges from 5% to 35%, and the major cause is due to the late maturation of the immune system and dietary changes in post-weaned piglets. Hence, a study evaluated the modification of humoral response in the intestine after dietary supplementation of probiotics ( Lactobacillus acidophilus , Lactobacillus rhamnosus and Bifidobacterium longum ) and zinc in pre- and post-weaned piglets [ 56 ]. The IgA + and IgM + B lymphocyte rate was higher in the probiotic-supplemented piglets than in the control group, irrespective of segments of intestine and age group.…”

Section: Immunomodulation Of B Lymphocytes By Prebiotics Probiotics A...mentioning

confidence: 99%

Immunomodulation of B Lymphocytes by Prebiotics, Probiotics and Synbiotics: Application in Pathologies

2023

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Introduction: Prebiotics, probiotics and synbiotics are known to have major beneficial effects on human health due to their ability to modify the composition and the function of the gut mucosa, the gut microbiota and the immune system. These components largely function in a healthy population throughout different periods of life to confer homeostasis. Indeed, they can modulate the composition of the gut microbiota by increasing bacteria strands that are beneficial for health, such as Firmicute and Bifidobacteria, and decreasing harmful bacteria, such as Enteroccocus. Their immunomodulation properties have been extensively studied in different innate cells (dendritic cells, macrophages, monocytes) and adaptive cells (Th, Treg, B cells). They can confer a protolerogenic environment but also modulate pro-inflammatory responses. Due to all these beneficial effects, these compounds have been investigated to prevent or to treat different diseases, such as cancer, diabetes, allergies, autoimmune diseases, etc. Regarding the literature, the effects of these components on dendritic cells, monocytes and T cells have been studied and presented in a number of reviews, but their impact on B-cell response has been less widely discussed. Conclusions: For the first time, we propose here a review of the literature on the immunomodulation of B-lymphocytes response by prebiotics, probiotics and synbiotics, both in healthy conditions and in pathologies. Discussion: Promising studies have been performed in animal models, highlighting the potential of prebiotics, probiotics and synbiotics intake to treat or to prevent diseases associated with B-cell immunomodulation, but this needs to be validated in humans with a full characterization of B-cell subsets and not only the humoral response.

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Section: Immunomodulation Of B Lymphocytes By Prebiotics Probiotics A...mentioning

confidence: 99%

Immunomodulation of B Lymphocytes by Prebiotics, Probiotics and Synbiotics: Application in Pathologies

2023

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Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs

Wiarda

Watkins

Gabler

et al. 2023

Developmental & Comparative Immunology

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Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs

Wiarda

Watkins

Gabler

et al. 2022

Preprint

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Intraepithelial T lymphocytes (T-IELs) are T cells located within the epithelium that provide a critical line of immune defense in the intestinal tract. In pigs, T-IEL abundances and phenotypes are used to infer putative T-IEL functions and vary by intestinal location and age, though investigations regarding porcine T-IELs are relatively limited. In this study, we expand on analyses of porcine intestinal T-IELs to include additional phenotypic designations not previously recognized in pigs. We describe non-conventional CD8α+CD8β- αβ T-IELs that were most prevalent in the distal intestinal tract and primarily CD16+CD27-, a phenotype suggestive of innate-like activation and an activated cell state. Additional T-IEL populations included CD8α+CD8β+ αβ, CD2+CD8α+ γδ, and CD2+CD8α- γδ T-IELs, with increasing proportions of CD16+CD27- phenotype in the distal intestine. Thus, putative non-conventional, activated T-IELs were most abundant in the distal intestine within multiple γδ and αβ T-IEL populations. A comparison of T-IEL and respective mucosal microbial community structures across jejunum, ileum, and cecum of 5- and 7-week-old pigs revealed largest community differences were tissue-dependent for both T-IELs and the microbiota. Between 5 and 7 weeks of age, the largest shifts in microbial community compositions occurred in the large intestine, while the largest shifts in T-IEL communities were in the small intestine. Therefore, results indicate different rates of community maturation and stabilization for porcine T-IELs and the mucosal microbiota for proximal versus distal intestinal locations between 5 and 7 weeks of age. Collectively, data emphasize the intestinal tract as a site of location- and age-specific T-IEL and microbial communities that have important implications for understanding intestinal health in pigs.

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Lymphocyte subsets in the small intestine of piglets fed with probiotic and zinc: a qualitative and quantitative micro-anatomical study

Cited by 4 publications

References 15 publications

Immunomodulation of B Lymphocytes by Prebiotics, Probiotics and Synbiotics: Application in Pathologies

Immunomodulation of B Lymphocytes by Prebiotics, Probiotics and Synbiotics: Application in Pathologies

Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs

Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs

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