Lymphocyte subsets in patients with acute myopericarditis, arrhythmias and dilated cardiomyopathy.

Koga, Yoshinori; Miyazaki, Yoshitaka; Toshima, Hironori; Hori, Yukio; Takamoto, Tetsuro; Yokoyama, Mineyuki

doi:10.1253/jcj.53.78

Cited by 7 publications

(7 citation statements)

References 23 publications

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“…Patients with myocarditis exhibit an imbalance between helper and cytotoxic T cells [52], providing further evidence that T-cell subpopulations play a great role in the pathogenesis of myocarditis. A recent study in patients with cardiomyopathy revealed a reduced activation of T helper type 1 (Th1) cells producing IFN- γ and an impaired production of IL-10, known as a major regulatory cytokine, downregulating an over-enhanced immune response [53].…”

Section: Immunopathology In Myocarditismentioning

confidence: 99%

Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy

Miteva

Linthout

Volk

et al. 2013

Stem Cells International

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Myocarditis is a common inflammatory cardiomyopathy, associated with cardiomyocyte apoptosis, which can lead to chronic left ventricular dysfunction. Under conventional heart failure therapy, inflammatory cardiomyopathy typically has a progressive course, indicating a need for alternative therapeutic strategies to improve long-term outcomes. Experimental and clinical studies consistently support the application of cellular transplantation as a strategy to improve myocardial function. Mesenchymal stromal cells (MSCs) mediate distinct paracrine effects supporting endogenous regeneration, but most important are their remarkable immunoregulatory properties. In this review, an overview of current knowledge on immunopathology in myocarditis will be given. Furthermore, current research regarding the immunomodulatory properties of MSCs in the context of myocarditis will be discussed. Finally, the impact of MSC priming by the environment on their functionality and the advantages of systemic administration of MSCs under myocarditis are outlined.

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Section: Immunopathology In Myocarditismentioning

confidence: 99%

Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy

Miteva

Linthout

Volk

et al. 2013

Stem Cells International

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“…In a similar manner, our patients with chronic progressive heart failure could manifest im mune abnormalities at specific windows of time during the natural history of their dis ease. In another study indicating elevated lev els on TNF in a spectrum of elderly patients, including some with heart failure, an attempt was made to correlate TNF elevation with weight loss as an indicator of disease severity, but such a correlation could not be found [24], Studies by Koike [11] and by Koga [28] have suggested that smoldering myocardial inflammation causing irreversible myocardial damage is related to immune dysfunction in some forms of heart failure [26], The mecha nism whereby immune activation and inflam mation might exert their effects in ischemic and hypertensive heart failure remains un known. Recent research has shown an asso ciation between free radicals and coronary artery disease [27], as well as an association between antioxidants and the early stages of congestive cardiomyopathy [28].…”

Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor, Natural Killer Activity and Other Measures of Immune Function and Inflammation in Elderly Men with Heart Failure

Pritchett¹,

Cohen²,

Rao³

et al. 1995

Gerontology

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Objective: To determine the status of tumor necrosis factor (TNF) and other measures of immunity and inflammation in chronic heart failure (CHF) in the elderly. Design: Comparative survey study of subjects with heart failure and age-matched controls. Settings: University affiliated tertiary care VA Medical Center, Heart Failure Clinic. Patients: Twenty men with New York Class II and III heart failure and 17 age-matched controls. Interventions: None. Main outcome measure: Levels of lymphocyte mitogenesis, TNF, natural killer (NK) cell activity, elastase-Α₁-antitrypsin (E/Α) and cross-linked fibrin D-dimers (XDP). Results: TNF levels (p = 0.27), NK activity (p = 0.56), and lymphocyte mitogenesis (p = 0.67) were similar in patients and controls. E/Α levels were somewhat lower in CHF patients (p = 0.05) and XDP were similar (p = 0.59). However, TNF levels were significantly related to NK activity and to E/Α activity in elderly men with heart failure but not controls. XDP were positively related to NK in heart failure patients but not controls. Conclusion: TNF and other measures of immune function and inflammation do not appear to be significantly elevated in elderly patients with heart failure of moderate severity. However, significant relationships exist between TNF, NK activity, XDP and E/Α in the heart failure patients only, suggesting that immune activation and subclinical inflammation does exist in these patients.

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“…For example, Koga et al [2] observed decreased concentrations of CD8 + (suppressor/cytotoxic T) cells in the peripheral blood of patients with acute myocarditis. In the investigations of concanavalin A stimulated suppressor T-cell activity, Eckstein et al [1] described a significant reduction of suppressor T cell activity in patients with myocarditis.…”

Section: Discussionmentioning

confidence: 99%

“…Recent clinical reports suggest that there is association between the decline in suppressor T-cell activity and the development of myocarditis [1,2], thus raising the possibility that augmentation of suppressor T-cell function might have a beneficial effect in acute viral myocarditis.…”

mentioning

confidence: 99%

Effects of lobenzarit on murine acute viral myocarditis

Yokoyama

Kanda

Suzuki

et al. 1992

Cardiovasc Drug Ther

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Lobenzarit (CCA) is a newly developed immunomodulating drug that has been demonstrated to enhance suppressor T-cell number and function. In this study we investigated the effect of CCA on murine myocarditis induced by the encephalomyocarditis (EMC) virus. Mice were first inoculated with the EMC virus. CCA (100 mg/kg) was administered daily for 14 days, starting on the day the mice were inoculated. The concentrations of Lyt2+ (suppressor/cytotoxic T) cells in the peripheral blood and heart were examined by laser flow cytometry and in situ staining. The concentration of Lyt2+ cells increased significantly in the peripheral blood and heart of CCA-treated mice when compared with untreated mice (blood: 23.0 +/- 2.6% vs. 18.8 +/- 2.8%, p less than 0.05; heart: 30.1 +/- 4.6% vs. 15.8 +/- 4.3%, p less than 0.05, respectively). Surprisingly, however, the severity of myocardial inflammation in CCA-treated mice was significantly greater than in untreated mice (area of inflammation: 33.1 +/- 10.5% vs. 18.8 +/- 19.5%, respectively, p less than 0.05). Thus, these findings suggest that CCA may aggravate EMC-induced acute myocarditis by enhancing the number of Lyt2+ cells.

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Lymphocyte subsets in patients with acute myopericarditis, arrhythmias and dilated cardiomyopathy.

Cited by 7 publications

References 23 publications

Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy

Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy

Tumor Necrosis Factor, Natural Killer Activity and Other Measures of Immune Function and Inflammation in Elderly Men with Heart Failure

Effects of lobenzarit on murine acute viral myocarditis

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