Lymphocyte Subsets and Mood States in Panic Disorder Patients

Park, Joo-Eon; Kim, Sang–Wook; Park, Quehn; Jeong, Do-Un; Yu, Bum-Hee

doi:10.3346/jkms.2005.20.2.215

Cited by 21 publications

(17 citation statements)

References 26 publications

(30 reference statements)

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“…Several studies have found no significant differences in cytokine levels between panic disorder patients and healthy subjects [10][11][12][13], as consistent with our results, except those related with the levels of IL-12 and IFN-γ. Park et al [24] found that panic disorder patients exhibited no differences with respect to the numbers of immune cells, except for a reduced proportion of T suppressor cells and an increased T helper cell/T suppressor cell ratio, as compared with normal healthy subjects. Reduced levels of IL-2 in panic disorder patients have also been reported [14].…”

Section: Discussionmentioning

confidence: 97%

Decreased IFN-γ and IL-12 levels in panic disorder

Tükel

Arslan

Ertekin

et al. 2012

Journal of Psychosomatic Research

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Section: Discussionmentioning

confidence: 97%

Decreased IFN-γ and IL-12 levels in panic disorder

Tükel

Arslan

Ertekin

et al. 2012

Journal of Psychosomatic Research

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“…) and alterations of other immune cell markers (Rapaport ; Park et al. ) in PD, with data showing heterogeneous results. No significant changes in any of these variables could be found during CO 2 inhalation‐induced panic (van Duinen et al.…”

Section: Laboratory/biological Studiesmentioning

confidence: 99%

How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways

et al. 2013

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Multiple studies have demonstrated an association between cigarette smoking and increased anxiety symptoms or disorders, with early life exposures potentially predisposing to enhanced anxiety responses in later life. Explanatory models support a potential role for neurotransmitter systems, inflammation, oxidative and nitrosative stress, mitochondrial dysfunction, neurotrophins and neurogenesis, and epigenetic effects, in anxiety pathogenesis. All of these pathways are affected by exposure to cigarette smoke components, including nicotine and free radicals. This review critically examines and summarizes the literature exploring the role of these systems in increased anxiety and how exposure to cigarette smoke may contribute to this pathology at a biological level. Further, this review explores the effects of cigarette smoke on normal neurodevelopment and anxiety control, suggesting how exposure in early life (prenatal, infancy, and adolescence) may predispose to higher anxiety in later life. A large heterogenous literature was reviewed that detailed the association between cigarette smoking and anxiety symptoms and disorders with structural brain changes, inflammation, and cell-mediated immune markers, markers of oxidative and nitrosative stress, mitochondrial function, neurotransmitter systems, neurotrophins and neurogenesis. Some preliminary data were found for potential epigenetic effects. The literature provides some support for a potential interaction between cigarette smoking, anxiety symptoms and disorders, and the above pathways; however, limitations exist particularly in delineating causative effects. The literature also provides insight into potential effects of cigarette smoke, in particular nicotine, on neurodevelopment. The potential treatment implications of these findings are discussed in regards to future therapeutic targets for anxiety. The aforementioned pathways may help mediate increased anxiety seen in people who smoke. Further research into the specific actions of nicotine and other cigarette components on these pathways, and how these pathways interact, may provide insights that lead to new treatment for anxiety and a greater understanding of anxiety pathogenesis.

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“…However, other studies have shown that there was no difference in T-lymphocyte subsets between panic disorder patients and control groups 14,15). There should be more consideration for these results, and the precise molecular mechanisms of antiviral immunologic pathways should be studied further.…”

Section: Discussionmentioning

confidence: 87%

Recurrence of Panic Attacks after Influenza Vaccination: Two Case Reports

Kim

Jeon

Yoon

2016

Clin Psychopharmacol Neurosci

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Human influenza is a contagious respiratory illness caused by the influenza virus. The influenza vaccination is recommended annually, but several adverse effects related to allergic reactions have been reported. Panic attacks are also known to occur, but no case of a panic attack adverse effect has been reported in South Korea. We present two cases of panic disorder patients whose symptoms were aggravated by the influenza vaccination. We assumed that dysregulation of T-lymphocytes in panic disorder patients could have a role in activating various kinds of cytokines and chemokines, which then can lead to panic attack aggravation.

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Lymphocyte Subsets and Mood States in Panic Disorder Patients

Cited by 21 publications

References 26 publications

Decreased IFN-γ and IL-12 levels in panic disorder

Decreased IFN-γ and IL-12 levels in panic disorder

How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways

Recurrence of Panic Attacks after Influenza Vaccination: Two Case Reports

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