Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone

Kieß, Wieland; Malozowski, Saúl; Gelato, Marie C.; Butenand, O.; Doerr, H. G.; B, Crisp; Eisl, E.; Maluish, Annette E.; Belohradsky, Bernd H.

doi:10.1016/0090-1229(88)90159-6

Cited by 75 publications

(34 citation statements)

References 15 publications

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“…These results also explain the apparent contradiction between the proposed importance of the IGFs in in vitro hematopoietic cell development and the clinical observations which suggest otherwise. Animals and humans with isolated growth hormone deficiency have no obvious hematologic abnormalities (2,38,39). Similarly, acromegalic patients who suffer from unregulated production of growth hormone do not have the enhanced erythropoiesis that is seen in patients with elevated erythropoietin levels (40).…”

Section: Methodsmentioning

confidence: 99%

A reappraisal of the role of insulin-like growth factor I in the regulation of human hematopoiesis.

Ratajczak

Kuczyński²,

Onodera³

et al. 1994

J. Clin. Invest.

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Section: Methodsmentioning

confidence: 99%

A reappraisal of the role of insulin-like growth factor I in the regulation of human hematopoiesis.

Ratajczak

Kuczyński²,

Onodera³

et al. 1994

J. Clin. Invest.

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“…1977;Berczi and Nagy 1987;Tapson and Berman 1987;Gruler et al 1988;Kelley 1988Kelley , 1989Baxter et al , 1991Blalock 1989; Guarcello et al 1989;Rothe and Falanga 1989;Green and Berman 1990;Sara and Hall 1990;Blalock 1990, 1991;Gelato 1993 responses that are T cell-dependent (Fabris et al 1971a;van Buul-Offers et al 1981;Roth et al 1984;reviewed by Berczi 1986;Kelley 1989). Observed effects of GH deficiency on the human immune system have been less consistent (Crist et al 1987;Rapaport et al 1987;Bozzola et al 1988bBozzola et al 1989Kiess et al 1988;Spadoni et al 1989 (Roth et al 1984) were treated with GH. Similarly, the deficient cellular responses of lymphocytes from hypophysectomized rodents were reversed to normal levels by GH administration (Berczi et al 1985).…”

Section: Effects Of Growth Hormone On Body Conditionmentioning

confidence: 99%

A review of bovine growth hormone

Burton¹,

McBride²,

Block³

et al. 1994

Can. J. Anim. Sci.

132

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. 74: 16'7-201. Unprecedented numbers of technical papers, abstracts, and short communications have been published in the past decade regarding the effects of exogenous bovine growth hormone on milk production, health, and reproductive efficiency of treated dairy cows. In well-managed dairy herds, exogenous growth hormone increases milk production without altering normal variability in milk composition. This has held true regardless of dairy breed tested, geographical location studied, or feeding management system used. Also consistent across studies is the rapidity of the galactopoietic effect of administered bovine growth hormone, which arises from altered partitioning and use of post-absorptive nutrients and increased synthetic capacity of the mammary gland. Growth hormone and its associated peptide, insulin-like growth factor-I, are now known to provide chronic lipolytic, diabetogenic, and gluconeogenic signals to target tissues culminating in increased mammary gland availability of glucose and nonesterified fatty acids. Together with yet ill-defined effects on mammary secretory tissue, this homeorhetic control of metabolism elicited by exogenous growth hormone is so efficient that treated cows are not more susceptible to metabolic disorders than untreated cows. However, some studies have reported an increased frequency of mastitis in groups of treated cows. This has been attributed mainly to increased milk volume in the mammary glands of treated cows and no convincing data are available that show decreased mammary gland immunity as a result of growth hormone treatments. On the contrary, an expanding body of evidence implicates growth hormone as a key neuroendocrine factor that is required for immunological competence. Trends of decreased reproductive efficiency in cows treated with growth hormone have also been reported, but available data imply that this is probably an indirect effect via prolonged negative energy balance in cows treated in early lactation rather than a direct negative effect on estrous cycling via altered reproductive hormone profiles. The objectives of the present review are to bring into focus and summarize pertinent biological discoveries regarding the treatment of dairy cows with recombinant bovine growth hormone, and to explore areas where additional growth hormone research is needed or warranted.Key words: Growth hormone, somatotropin, dairy cows, insulin-like growth factor-I Burton, J. L., McBride, B. W., Block, E., Glimm, D. et Kennelly,E. 1994. L'horrnone de croissance bovinemais au point bibliographique. Can. J. Anim. Sci. 74: . D'innombrables m6moires techniques, r6sum6s analytiques et communications brdves ont 6t6 publi6s dans la dernidre d6cennie au sujet des effets de I'hormone de croissance bovine exogdne sur la production laitidre, sur la sant6 et sur les fonctions de reproduction des vaches laitidres trait6es. Dans les 6levages laitiers bien conduits, la GH exogbne accroit la production de lait sans modifier la variabilit6 normale de sa composition, et cela inddpendamme...

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“…Proportions of total T cells and CD4+ cells were similar to controls, whereas B and CD8+ cells were, in some patients, more numerous than in controls. No consistent differences in T-cell populations were found in GH-deficient patients, and treatment with GH-releasing hormone did not alter these levels [49]. Thus, these studies suggest no strong link between pituitary hormone deficiency and immunological impairment in humans, but obviously a complete understanding of the importance of neuroendocrine hormones to human immune development and function is hampered by small populations in clinical studies and the impossibility of obtaining lymphoid tissue samples from patients that are readily harvested from rodents.…”

Section: Effects Of Neuroendocrine Hormones On Immune Parametersmentioning

confidence: 81%

“…Treatment of hypophysectomized mice with GH restored NK function [31]. GH-deficient patients have reduced NK cell numbers and activity, compared to healthy controls [49,83]. Short-term treatment with either GH or GH-releasing hormone did not restore NK function in patients with hypothalamic deficiencies [49].…”

Section: Neuroendocrine Effects On Nk Cellsmentioning

confidence: 99%

Use of Neuroendocrine Hormones to Promote Reconstitution after Bone Marrow Transplantation

Woody

Li²,

Richards³

et al. 1999

Neuroimmunomodulation

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A survey of the previous literature and the data shown here indicate that neuroendocrine hormones such as growth hormone and prolactin may be of potential clinical use after bone marrow transplantation (BMT) to promote hematopoietic and immune recovery. The amounts of hormones used in our model do not promote weight gain suggesting that their lymphohematopoietic actions were independent of their anabolic effects. While the hormones may not produce the same extent of immune/hematopoietic effects when compared to conventional hematopoietic and immune stimulating cytokines (i.e. IL-2 or G-CSF), their pleiotropic effects and limited toxicity after systemic administration makes them attractive to test in the post-BMT setting. However, more work needs to be performed to understand the mechanism(s) of their action, particularly with regard to T-cell function and development.

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Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone

Cited by 75 publications

References 15 publications

A reappraisal of the role of insulin-like growth factor I in the regulation of human hematopoiesis.

A reappraisal of the role of insulin-like growth factor I in the regulation of human hematopoiesis.

A review of bovine growth hormone

Use of Neuroendocrine Hormones to Promote Reconstitution after Bone Marrow Transplantation

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