Lymphocyte subpopulations, levels of interferon, and expression of their receptors in patients with chronic hepatitis B and C: Correlation with the species of viruses and the degree of liver fibrosis

Kalyuzhin, O. V.; Понежева, Ж.Б.; Semenova, I V; Khokhlova, O.N.; Serebrovskaya, L. V.; Guseva, Tatiana S.; Паршина, О В; Maleev, V V

doi:10.17116/terarkh2017891114-20

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…Many studies have shown that carriers of hepatitis B surface antigen (HBsAg) have higher risk of HCC compared to HBsAg negative cases 4 . Several other studies showed that hepatitis B and C infections may increase the risk of lymphoid malignancies 5 , pancreatic cancer 6 , liver fibrosis 7 and chronic kidney disease 8 . Moreover, studies have shown that hepatitis C virus (HCV) is present not only in hepatocytes, but also in patients' plasma and serum.…”

Section: Introductionmentioning

confidence: 99%

Kashmiri refugees at the verge of hepatitis B and C epidemic in the State of Azad Jammu and Kashmir, Pakistan

Kazmi¹,

Rauf

Shafique

et al. 2022

Rev. saúde pública

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OBJECTIVE: To determine the seroprevalence of hepatitis B and C among immigrants residing refugee camps in Muzaffarabad, Azad Kashmir, Pakistan, and to identify possible risk factors for HBV and HCV transmission. METHODS: Around 1,225 individuals inhabiting Muzaffarabad refugee camps, participated in the study. A qualitative Immuno-Chromatographic Technique was used for initial screening and PCR test was used for detection of HBV and HCV in participants. The major risk factors for HBV and HCV transmission were assessed using a questionnaire approach. RESULTS: Around 86 (7.0%) individuals were observed for HBsAg presence, and 215 (17.5%) individuals were found positive for Anti-HCV. Only 32 (2.6%) individuals were confirmed for HBV DNA and 126 (10.3%) individuals were positive for HCV RNA after PCR. Demographically, both HBsAg and Anti-HCV were found more prevalent in female (4.4% HBsAg and 10.8% Anti-HCV) population as compared to male (2.6% HBsAg and 6.7% Anti-HCV) population. Surprisingly, the HBsAg (23.5%) and Anti-HCV (41.1%) appeared to be more frequent in the age group 62–75 years. Previous history of hepatitis in the family (p < 0.0001), blood transfusion (p = 0.0197) dental treatment (p < 0.0001) and tattooing or piercing on any part of the body (p = 0.0028) were assessed as significant risk factors in HBV and HCV transmission. CONCLUSIONS: Presence of 7.0% HBsAg and 17.5% Anti-HCV in a small fragment of the migrant population cannot be overlooked. Lack of awareness among people and negligence of health department could escalate the situation.

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Section: Introductionmentioning

confidence: 99%

Kashmiri refugees at the verge of hepatitis B and C epidemic in the State of Azad Jammu and Kashmir, Pakistan

Kazmi¹,

Rauf

Shafique

et al. 2022

Rev. saúde pública

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Interferons alpha and gamma, pidotimod, and tilorone in the treatment of acute respiratory infections in patients with allergic rhinitis: a prospective, cohort clinical and immunological study

et al. 2022

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Aim. To compare the clinical efficacy and influence on interferon (IFN) production / sensing of drugs with immunemediated antiviral effects, which potentiate type 1 (T1) immune responses, in the treatment of acute respiratory infections (ARI) in patients with allergic rhinitis.Materials and methods. 146 ARI patients with remission of seasonal allergic rhinitis were divided into 4 cohorts. In addition to symptomatic therapy, patients received either 2,000 IU of IFNγ in each nasal passage 5 times a day; or rectal suppositories containing 106 IU of IFN-α2b and antioxidants (AO) twice a day, and a gel with IFN-α2b and AO intranasally 3 times a day; or 400 mg of pidotimod per os twice a day; or 125 mg of tilorone per os on days 1, 2, 4, and 6. The severity of ARI was determined daily as the sum of 10-point scores for 15 symptoms. Serum concentrations of IFNα and IFNγ and the ability of blood cells to produce these cytokines ex vivo spontaneously and upon stimulation with Newcastle disease virus or phytohemagglutinin were studied using enzyme-linked immunosorbent assay (ELISA). The proportions of circulating lymphocytes expressing type I IFN receptor subunit 2 (CD118) or IFNγ receptor α-chain (CD119) were determined by flow cytometry.Results. ARI symptoms in all cohorts generally regressed in a similar way. However, from day 5 of the treatment, pidotimod relieved symptoms more effectively than other drugs. In patients treated with tilorone, the regression of ARI manifestations was delayed in the first two to three days, followed by rapid symptom reduction. An initial decrease in the induced production of IFNγ was found in patients treated with pidotimod, and a tendency to a decrease in this parameter was noted in other cohorts. The induced production of IFNγ after the treatment in all groups did not differ from that in healthy donors. No significant changes and differences in the proportions of CD118+ and CD119+ lymphocytes were found between the cohorts, except for a decrease in the number of CD118+ cells after the treatment with tilorone. In patients treated with IFN-α2b + AO, the proportions of CD119+ and CD118+ lymphocytes tended to increase slightly.Conclusion. Drugs that promote the development of T1 over T2 immune responses are a useful option for treating ARI in patients with allergic rhinitis.

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Current Issues of Antiviral Therapy of Arvi and Influenza in Military Units

Малиновская

Мосягин²,

Коржов

2020

Morsk. med.

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Conducting preventive medical and epidemiological measures for influenza and ARVI in closed military units, including on ships, vessels and auxiliary units of the Navy, is a factor of increasing the combat effectiveness of forces of the Russian Army. In the structure of total morbidity of military personnel, acute respiratory viral infections account for 35–50%, however, during the young military reinforcement, the incidence of these infections in combination with community-acquired pneumonia can reach 70–80%. The risk of exceeding the epidemiological threshold for respiratory tract infections, the etiological basis of which is viral aggression, is especially important in newly formed military contingents, for units participating in local military conflicts and peacekeeping operations, as well as with a new recruitment of cadets at training centers. The use of non-specific antiviral drugs based on exogenous recombinant interferon -2b is one of the conditions for adequate prevention of influenza and ARVI in closed military units. The paper presents the results from the analysis of publications on the effectiveness and Viferon® safety in the treatment of influenza and ARVI. Viferon is a preparation of recombinant human interferon -2b with a complex of antioxidants in various dosage forms, used in the treatment and prevention of acute respiratory viral infections and influenza. Use of Viferon in various dosage forms is a reliable method of prevention and treatment of influenza and other acute respiratory viral infections in military forces, including on ships, vessels and auxiliary units of the Navy, at risk of emergency epidemiological situations due to ARVI and influenza, in conditions of limited contingent.

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Lymphocyte subpopulations, levels of interferon, and expression of their receptors in patients with chronic hepatitis B and C: Correlation with the species of viruses and the degree of liver fibrosis

Cited by 4 publications

References 2 publications

Kashmiri refugees at the verge of hepatitis B and C epidemic in the State of Azad Jammu and Kashmir, Pakistan

Kashmiri refugees at the verge of hepatitis B and C epidemic in the State of Azad Jammu and Kashmir, Pakistan

Interferons alpha and gamma, pidotimod, and tilorone in the treatment of acute respiratory infections in patients with allergic rhinitis: a prospective, cohort clinical and immunological study

Current Issues of Antiviral Therapy of Arvi and Influenza in Military Units

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