Lymphocyte Subpopulations in Patients With Untreated Pernicious Anaemia

Soler, J. L. Fuster; Remacha, Ángel F.; Nieto, Merce; Gimferrer, E

doi:10.1111/j.1600-0609.1985.tb01725.x

Cited by 8 publications

(1 citation statement)

References 2 publications

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“…In contrast to these observations, Soler et al [9] and Carmel et al [10] reported that in patients with pernicious anemia there was no increase in CD4+/CD8+ ratio or a significant decrease in CD8+ absolute number. Cyanocobalamin has been reported to restore both abnormal CD4+/CD8+ ratio, and decrease in absolute number of CD8+, but no change in absolute number of CD4+ cells was observed [6] .…”

Section: Discussionmentioning

confidence: 53%

Effects of Cyanocobalamin on Immunity in Patients with Pernicious Anemia

Erkurt

Aydoğdu

Dikilitaş³

et al. 2008

Med Princ Pract

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Objective: The aim of the study was to evaluate the role of vitamin B₁₂ in patients with pernicious anemia. Materials and Methods: This study was conducted prospectively at the Turgut Özal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B₁₂ effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count. Results: In vitamin B₁₂-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated. Conclusion: These findings suggest that vitamin B₁₂ has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B₁₂ replacement therapy.

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Section: Discussionmentioning

confidence: 53%

Effects of Cyanocobalamin on Immunity in Patients with Pernicious Anemia

Erkurt

Aydoğdu

Dikilitaş³

et al. 2008

Med Princ Pract

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Restoration of decreased suppressor cells by vitamin B₁₂therapy in a patient with pernicious anemia

et al. 1987

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A unique case of pernicious anemia is described. Initially, the percentage of OKT8-positive blood cells was markedly decreased, resulting in an increase in the OKT4/OKT8 ratio. The level of OKT8-positive blood cells was, however, returned to normal after vitamin B12 therapy. The finding may propose a possible role of the imbalance of blood lymphocyte subpopulations on the pathogenesis of pernicious anemia and also a responsibility of vitamin B12 for such a selective reduction in the OKT8-positive blood cells.

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Lymphocyte surface phenotypes in pernicious anemia

1987

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Because an immunological defect of an unknown nature is thought to be a factor in the pathogenesis of pernicious anemia, we studied lymphocyte surface phenotypes in 40 patients and compared them with 113 healthy controls. The only significant difference that emerged was in their slightly decreased number and proportion of surface immunoglobulin (lambda chain) -bearing cells. Of specific interest, the numbers of OKT4+ and OKT8+ lymphocytes and the T4+/T8+ ratios were not significantly different from control values. A sizable minority of patients had increased ratios, while a smaller number had decreased values. No explanation or identifying feature was apparent for those patients with either increased or decreased T4+/T8+ ratios. (One patient with a very low ratio, who was excluded from our analysis, developed acquired immune deficiency syndrome.) No differences were apparent in T4+/T8+ ratios or any other lymphocyte surface phenotypic characteristics when patients were segregated by presence of anti-intrinsic factor antibody or anti-parietal cell antibody, or by race, sex, or age. Our results in a racially heterogeneous group of patients do not support the suggestion that T4+/T8+ ratios are usually abnormal in prenicious anemia or that the presence of anti-intrinsic factor antibody is associated with such abnormality.

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Lymphocyte Subpopulations in Patients With Untreated Pernicious Anaemia

Cited by 8 publications

References 2 publications

Effects of Cyanocobalamin on Immunity in Patients with Pernicious Anemia

Effects of Cyanocobalamin on Immunity in Patients with Pernicious Anemia

Restoration of decreased suppressor cells by vitamin B₁₂therapy in a patient with pernicious anemia

Lymphocyte surface phenotypes in pernicious anemia

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Lymphocyte Subpopulations in Patients With Untreated Pernicious Anaemia

Cited by 8 publications

References 2 publications

Effects of Cyanocobalamin on Immunity in Patients with Pernicious Anemia

Effects of Cyanocobalamin on Immunity in Patients with Pernicious Anemia

Restoration of decreased suppressor cells by vitamin B12therapy in a patient with pernicious anemia

Lymphocyte surface phenotypes in pernicious anemia

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Product

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Restoration of decreased suppressor cells by vitamin B₁₂therapy in a patient with pernicious anemia