Lymphocyte studies in familial chronic lymphatic leukemia

Branda, Richard F.; Ackerman, Samuel; Handwerger, Barry S.; Howe, Robert B.; Douglas, Steven D.

doi:10.1016/0002-9343(78)90238-3

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…If the Gunz et al (1975) 3 first degree; 3 others Petzholdt et al (1976) Siblings M55, M63, M65 Fazekas et al (1978) Siblings, M57, M65, M70. Branda et al (1978) Parent F79; offspring M54 Conley et al (1980) Siblings F76, F Siblings M69, M Nephew 48; maternal aunt M62; great aunt Alfinito et al (1982) Siblings F52, F58 Vanni & Deambrogio (1983) Siblings F66 genetic basis of familial CLL involves a similar mechanism, this offers a novel method of identifying a predisposition locus for the disease.…”

Section: Discussionmentioning

confidence: 99%

Familial chronic lymphocytic leukaemia: a survey and review of published studies

Yuille¹,

Matutes²,

Marossy³

et al. 2000

Br J Haematol

109

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B-cell chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia. To gain insight into the role of inherited factors in the disease, we have conducted a survey of the family histories of 268 CLL patients and have reviewed published familial cases and epidemiological studies. The results of our survey and published studies strongly support the hypothesis that a subset of the disease can be ascribed to a genetic predisposition. The most likely genetic model for inherited predisposition appears to be dominantly acting genes with pleiotropic effects because in many families CLL appears to be associated with other lymphoproliferative disorders.

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Section: Discussionmentioning

confidence: 99%

Familial chronic lymphocytic leukaemia: a survey and review of published studies

Yuille¹,

Matutes²,

Marossy³

et al. 2000

Br J Haematol

109

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“…Study population Familial CLL cases were obtained from two sources: the published medical literature (Rosenow, 1925; Riccitelli & Ragnotti, 1927; Curschmann, 1936; Videbaek, 1947; Gunz & Dameshek, 1957; Furbetta & Solinas, 1961; Wisniewski & Weinreich, 1966; Branda et al , 1978; Yuille et al , 1998; Bevan et al , 1999; Goldin et al , 1999; Payelle‐Brogard et al , 1999; Pritsch et al , 1999; Sakai et al , 2000) and our series of unpublished families with multigenerational CLL. Our series consists of all multigenerational familial cases seen by the authors and all responses to multiple worldwide web sites in which details on familial haematological malignancies were solicited from physicians and patients.…”

Section: Methodsmentioning

confidence: 99%

Anticipation in familial chronic lymphocytic leukaemia

Wiernik

Ashwin

et al. 2001

Br J Haematol

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Summary. Anticipation, a phenomenon in which an inherited disease is diagnosed at an earlier age in each successive generation of a family, has been demonstrated in certain heritable neurological disorders and in multiple myeloma, non-Hodgkin's lymphoma and other haematological neoplasms. The present study was conducted to determine whether anticipation occurs in familial chronic lymphocytic leukaemia (CLL). Fourteen published reports of multigenerational familial CLL were analysed for anticipation, together with 10 previously unreported families with familial CLL, and the difference in disease-free survival between generations was determined. The difference between age at onset for each affected parent±child pair was tested against the null hypothesis that there was no difference in age at onset. The age at onset of the studied cases was also compared with that of the Surveillance Epidemiology and End Results (SEER) Program of the U.S. National Cancer Institute. The median ages at onset in the child and parent generations of all families (51´0 and 72´0 years respectively) were significantly different (P , 0´000001), and the null hypothesis was rejected (P , 0´000001). A significant difference was observed between the ages of onset of the child generation and the SEER population (P , 0´00001), but not between the parent generation and the SEER population. Anticipation characterizes familial CLL.

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“…The established relationship between HLA and Hodgkin's 51 Sibs M, M Sib M LK Videbaek 1958 52 Uncle, nephew Hudson et al 1960 53 Sibs M, M; Sibs M, M Gunz et al 1962 54 Sibs F, M, M Fitzgerald et al 55 Furbetta et al 1963 56 Grandparent M, parent F, offspring F Wisniewski 1966 57 Parent M, offspring M Rigby 1966 58 2 half-sibs Ardizzone et al 1968 59 Sibs M, M Magaraggia et al 1968 60 Sibs M, M McPhedran et al 1969 61 Sibs F, M, F, cousins F, M, M Fraumeni et al; 62 Blattner et al 1969 63 Sibs F, M, M Gunz et al 1969 64 Sibs M, F Sib CGL Sibs M, M Undritz et al 1971 65 Sibs M, M, M, F Potolosky et al 1971 66 Sibs F, F Sib LY, sib LY, sib acute LK Schweitzer et al 1973 67 Sibs F, M, M, F, F Blattner et al; 68 Neuland et al; 69 Shen et al; 70 Parent M, offspring M, M, F, F Caporaso et al 1991 71 Gunz 1975 72 3 first degree; 3 others Petzholdt 1976 73 Sibs M, M, M Fazekas et al 1978 74 Sibs, M, M, M Branda et al 1978 75 Parent F; offspring M Conley et al 1980 76 Sibs F, F Sibs M, M Nephew, maternal aunt; Nephew M; greataunt Alfinito et al 1982 77 Sibs F, F Vanni et al 1983 78 Sibs F, F Brok-Simoni et al 79 MZ twins F, F, sib F Hakim et al 1987 80 Eriksson et al 1987 81 Sibs M, M; Sibs M, F; Sibs M, F; MZ twins M; Parent M, offspring M; Parent M, offspring M Shah et al 1992 82 Sibs F, M, F Cuttner 1993 83 Sibs M, M; Sib M NHL Parent M, offspring M; MZ twins M, M Fernhout et al 1997 84 Sibs F, F, F, F Yuille et al 2000 9 Parent …”

Section: Molecular Genetics Of Familial Chronic Lymphocytic Leukemiamentioning

confidence: 99%