Lymphocyte-rich pleural liposarcoma mimicking pericardial cyst

Iqbal, M J; Posen, J; Bhuiya, Tawfiqul; Lackner, Rudy P.; Steinberg, Harry; Rossoff, Leonard J.

doi:10.1067/mtc.2000.106971

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…Inclusive of our study, follow-up of >12 months is available for 115 patients with mediastinal liposarcoma, including 39 well-differentiated, 23 dedifferentiated, 28 myxoid, and 25 pleomorphic liposarcomas. [1][2][3][5][6][7][9][10][11][12]14,16,18,[20][21][22][23][24]27,28,[33][34][35][36][37][38][39][40][41]43,44,[46][47][48][49][52][53][54][55][56][59][60][61][62][63][64][67][68][69][70][71]…”

Section: Discussionmentioning

confidence: 99%

Liposarcomas of the Mediastinum and Thorax

Boland

Colby

Folpe

2012

American Journal of Surgical Pathology

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Liposarcoma rarely occurs in the mediastinum, and most reports predate the current genetically based classification system. We report the clinicopathologic and molecular genetic features of a series of thoracic liposarcomas identified over a 60-year period. Twenty-four confirmed cases were reclassified using the most recent World Health Organization classification. Fluorescent in situ hybridization for CPM amplification and/or DDIT3 rearrangement was performed on selected cases. The 24 cases occurred in 13 men and 11 women (mean age, 53 y; range, 15 to 73 y) and arose in all mediastinal compartments. All subtypes were encountered with 8 well-differentiated liposarcomas, 6 dedifferentiated liposarcomas (3 of 6 confirmed CPM+), 7 pleomorphic liposarcomas (2 of 7 confirmed CPM-, 1 of 7 confirmed DDIT3-), 2 myxoid liposarcomas, and 1 unclassifiable liposarcoma (CPM- and DDIT3-). Unusual histologic features included myxoid well-differentiated liposarcoma mimicking myxoid liposarcoma (2 cases), lipoleiomyosarcoma (1 case), dedifferentiated liposarcoma with "meningothelial"-like dedifferentiation, differentiated myxoid liposarcoma mimicking well-differentiated liposarcoma (CPM-), and pleomorphic liposarcoma with epithelioid and myxoid change. Follow-up information was available for 19 patients (mean, 55 mo; range, 8 to 252 mo). Outcome was strongly associated with histologic subtype, with death from disease occurring in 1 of 6 well-differentiated, 1 of 4 dedifferentiated, 5 of 7 pleomorphic, and 2 of 2 myxoid liposarcomas. The mediastinum shows a preponderance of uncommon subtypes and unusual morphologic variants. Correct classification has important implications, with most patients with well-differentiated/dedifferentiated liposarcoma having a protracted clinical course, in contrast to the more rapid disease progression seen in patients with myxoid and pleomorphic liposarcoma.

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Section: Discussionmentioning

confidence: 99%

Liposarcomas of the Mediastinum and Thorax

Boland

Colby

Folpe

2012

American Journal of Surgical Pathology

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“…Lymphocytes, including T cells, have also been reported in one other case of a cystic liposarcoma of the pleura 22. In fact, for conventional (non-cystic) liposarcoma, ‘lymphocyte-rich’ variants have been described previously by others23 24 and recently, by our own group 25 26…”

Section: Discussionmentioning

confidence: 69%

Multicystic dedifferentiated retroperitoneal liposarcoma: tumour cyst fluid analysis and implications for management

et al. 2015

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SUMMARYLiposarcomas are soft tissue sarcomas of adipocyte origin. We describe a case of a dedifferentiated retroperitoneal liposarcoma with an unusual presentation on recurrence as a large, multicystic tumour. The patient was a 72-year-old woman who had undergone multiple treatments including two prior resections. For her most recent locoregional disease recurrence, the patient was offered surgical debulking for symptom palliation. At this operation, performed after two cycles of chemotherapy, the tumour cyst fluid was analysed and found to have a predominance of immune cells with no identifiable malignant cells. This case and the results of our tumour cyst fluid analysis raise several interesting considerations for the management of this unique situation in a rare disease. BACKGROUND

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“…4,8 The most common sites of liposarcoma are the deep soft tissue of the trunk and retroperitoneum and the subcutaneous fat of the upper and lower extremities. The 5-year survival of patients undergoing curative resection or radiation therapy is about 50%.…”

Section: Discussionmentioning

confidence: 99%

Primary liposarcoma of the mediastinum

Mase

Kawawaki

Narumiya

et al. 2002

Jpn J Thorac Caridovasc Surg

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Primary mediastinal liposarcomas are extremely rare malignancies that remain asymptomatic until large and, even then, initial symptoms are nonspecific. We report a 48-year-old man followed up for asymptomatic multiple bullae who suffered progressive weight loss and dyspnea on exertion. Radiography and computed tomography of the chest showed a large mass with calcified nodules in the left pleural cavity and giant bullae in the right pleural cavity. Previous computed tomography of the chest showed a small tumor of mediastinal adipose tissue with calcified nodules. Tumor growth was calculated at about 500 times the tumor volume per 3.6 years. We completely resected the mediastinal tumor and conducted a bullectomy through a median sternotomy. The microscopic pathological diagnosis was well-differentiated/sclerosing liposarcoma. The man underwent no postoperative adjunctive irradiation and remains well 8 months after surgery.

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Lymphocyte-rich pleural liposarcoma mimicking pericardial cyst

Cited by 7 publications

References 6 publications

Liposarcomas of the Mediastinum and Thorax

Liposarcomas of the Mediastinum and Thorax

Multicystic dedifferentiated retroperitoneal liposarcoma: tumour cyst fluid analysis and implications for management

Primary liposarcoma of the mediastinum

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