Lymphocyte responsiveness of children supplemented with vitamin A and zinc

Kramer, Tim R.; Udomkesmalee, Emorn; Dhanamitta, Sakorn; Sirisinha, Stitaya; Charoenkiatkul, Somsri; Tuntipopipat, Siriporn; Banjong, Orapin; Rojroongwasinkul, Nipa; Smith, James C.

doi:10.1093/ajcn/58.4.566

Cited by 23 publications

(6 citation statements)

References 7 publications

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“…Also, the proportion of abnormal conjunctival impression cytology results decreased in children who received both zinc and vitamin A (27). In another study (44), children who were supplemented with both zinc and vitamin A tended to show higher proliferative responsiveness of T lymphocytes to purified protein derivatives than did those treated with placebo (P = 0.08). All of these observations suggest the existence of an interaction between zinc and vitamin A in children.…”

Section: Discussionmentioning

confidence: 95%

Synergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children

Rahman

Wahed

Fuchs

et al. 2002

The American Journal of Clinical Nutrition

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Background: Zinc deficiency limits the bioavailability of vitamin A. Because zinc and vitamin A deficiency often coexist in malnourished children, simultaneous zinc and vitamin A supplementation may improve the vitamin A deficiency in these children. Objective: A randomized, double-blind, placebo-controlled intervention trial was conducted to evaluate whether combining zinc and vitamin A supplementation would improve the biochemical indexes of vitamin A nutriture. Design: Children aged 12-35 mo were randomly assigned to 1 of 4 intervention groups: 20 mg Zn/d for 14 d (Z group), 60 000 retinol equivalents (200 000 IU) vitamin A on day 14 (A group), zinc plus vitamin A (ZA group), or placebo syrup and placebo capsule (placebo group). Venous blood was drawn at enrollment and on day 21. Results: Mean serum retinol concentrations were not significantly different between the A and ZA groups. Among vitamin A-deficient children, the proportion of children who remained vitamin A deficient (serum retinol < 0.7 mol/L) after supplementation was 40.6% in the Z group, 37.5% in the A group, and 47.0% in the placebo group; only 13.3% in the ZA group remained vitamin A deficient (P < 0.05 compared with the placebo group). The proportion of children whose retinol binding protein concentrations remained low was significantly lower in the ZA group than in the other groups (P < 0.05). Conclusion: Combined zinc and vitamin A supplementation improves vitamin A nutriture in vitamin A-deficient children.

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Section: Discussionmentioning

confidence: 95%

Synergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children

Rahman

Wahed

Fuchs

et al. 2002

The American Journal of Clinical Nutrition

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“…The effect of zinc on the different cells involved in inflammation, such as mast cells, 59-61 platelets, 62 macrophages, [62][63][64][65][66][67] neutrophils, 68,69 natural killer cells, 70,71 and lymphocytes, [72][73][74][75] is cell type specific; zinc can also influence the cytokine messengers that facilitate communication with these cells. [76][77][78][79][80] In some cases, elevated zinc levels have a predominantly inhibitory effect, such as with mast cells and platelets.…”

Section: Effect Of Zinc On Immunologic Cells and Cytokinesmentioning

confidence: 99%

Zinc and Skin Health

Schwartz

Marsh²,

Draelos³

2005

Dermatologic Surgery

110

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“…calcium, phosphorus, iron, vitamin A and zinc) have been reported among preschool (Chusilp et al 1992; Ministry of Public Health, 1995) and school-aged children (Bloem et al 1989; Egger et al 1991; Udomkesmalee et al 1992). Deficits in some of these micronutrients in school-aged children have been associated with reduced linear growth, as well as impaired immune competence, cognition and school performance (Soemantri et al 1985; Kramer et al 1993; Sandstead et al 1998; Van Stuijvenberg et al 1999). If these micronutrient deficits persist, the likelihood of catch-up growth is diminished.…”

mentioning

confidence: 99%

Does zinc deficiency play a role in stunting among primary school children in NE Thailand?

et al. 2007

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Stunting in school-age years may result in a decrease in adult size, and thus reduced work capacity and adverse reproductive outcomes. We have compared the mean intakes of energy, protein and selected growth-limiting nutrients in fifty-eight stunted children and 172 non-stunted controls drawn from 567 children aged 6 -13 years attending ten rural schools in NE Thailand. Control children were selected randomly after stratifying children by age in each school. Dietary data were calculated from 24-h recalls using nutrient values from Thai food composition data and chemical analysis. Inter-relationships between stunting and sociodemographic, anthropometric and biochemical variables were also examined. Biochemical variables investigated were serum albumin, zinc, ferritin, transferrin receptor and retinol, and iodine in casual urine samples. Significantly more males than females were stunted (males, n 38, 65·5 % v. females, n 20, 34·5 %; P¼ 0·025). Stunted males had lower mean intakes of energy, protein, calcium, phosphorus and zinc, and a lower mean (95 % CI) serum zinc (9·19 (8·53, 9·84) v. 9·70 (8·53, 9·29) mmol/l) than non-stunted males; no other biochemical differences were noted. Stunted males also had a lower mean arm muscle area (P¼0·015), after adjusting for age, than nonstunted males. In conclusion, the lower dietary intakes of the stunted males compared to their non-stunted counterparts may be associated with anorexia and hypogeusia induced by zinc deficiency. Hence, zinc deficiency may be a factor limiting linear growth, especially among boys in NE Thailand, but more research is needed to establish whether other factors also play a role.

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Lymphocyte responsiveness of children supplemented with vitamin A and zinc

Cited by 23 publications

References 7 publications

Synergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children

Synergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children

Zinc and Skin Health

Does zinc deficiency play a role in stunting among primary school children in NE Thailand?

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