Lymphocyte responses to food antigens in patients with atopic dermatitis who are sensitive to foods

Kondo, Naomi; Agata, Hiroatsu; Fukutomi, Osamu; Motoyoshi, Fumiaki; Orii, Tadao

doi:10.1016/s0091-6749(05)80073-9

Cited by 94 publications

(66 citation statements)

References 15 publications

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“…We previously reported a similar study on canine food hypersensitivity [8]. In humans, a similar study was also reported in non-immediate type food hypersensitivity [10]. Consequently, performance of a lymphocyte stimulation test for possible food allergens may be useful in predicting offending food allergens in cats with food hypersensitivity.…”

supporting

confidence: 55%

“…On the other hand, the lymphocyte stimulation test has been shown to be useful for the diagnosis of food hypersensitivity in humans [10] and dogs [8]. There have been no reports on the lymphocyte stimulation test in feline food hypersensitivity, although a cat with Japanese cedar pollinosis was shown to have an antigen-specific lymphocyte blastogenic response against its pollen antigen [13].…”

mentioning

confidence: 99%

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Lymphocyte Blastogenic Responses to Food Antigens in Cats Showing Clinical Symptoms of Food Hypersensitivity

Ishida

Kurata²,

Masuda³

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Three cats were diagnosed as having food hypersensitivity by food elimination and oral food provocation tests. Twelve allergenic food ingredients were identified by oral food provocation test in the 3 cats. Of the 12 food ingredients, 9 offending food antigens were shown to be positive in a lymphocyte stimulation test; however, none of them were positive in antigen-specific IgE testing, and only four food antigens were positive in intradermal testing. The stimulation indices in the lymphocyte stimulation tests for the 9 food ingredients were found to be decreased after the cats were fed elimination diets. The present study demonstrates that the lymphocyte stimulation test reflects an immunologic reaction involved in food hypersensitivity and can help identify allergenic food ingredients in feline food hypersensitivity.

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supporting

confidence: 55%

mentioning

confidence: 99%

Lymphocyte Blastogenic Responses to Food Antigens in Cats Showing Clinical Symptoms of Food Hypersensitivity

Ishida

Kurata²,

Masuda³

et al. 2012

The Journal of Veterinary Medical Science

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“…may play a role [10]. Several reports indicate, however, that the LTT may not be useful in the diagnosis of food-, pollen-, or mite dust-allergy or hypersensitivity reactions toward insect toxins [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic relevance of the lymphocyte transformation test for sensitization to beryllium and other metals (IUPAC Technical Report)

Klein¹,

Schwenk²,

Heinrich‐Ramm³

et al. 2004

Pure and Applied Chemistry

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The lymphocyte transformation test (LTT) has been proven useful especially in the diagnosis of drug-induced allergic disorders. It is an in vitro test which is based on the fact that lymphocytes, which have been sensitized by a certain antigen, transform into blasts and proliferate when they are again exposed to this antigen. This proliferation is determined by measurement of the incorporation of [3H ]-thymidine or bromodeoxyuridine into replicating DNA. The test has the advantage over skin tests of avoiding re-exposure of individuals, and it was, therefore, hoped that it may also help to diagnose metal allergies and especially sensitization toward beryllium. However, the LTT measures only the sensitization of lymphocytes, but not the effector reaction, i.e., there may be positive results in exposed individuals even in the absence of clinical symptoms. There are several reports evaluating the LTT toward gold salts (Au), amalgam (Hg), nickel (Ni), beryllium (Be), and several other metals. With metals other than Be, the LTT appears to be of little use. In contrast, the LTT with Be may, indeed, define patients at risk of developing chronic beryllium disease (CBD), which affects mainly the respiratory tract and may even cause death. Beryllium sensitization progresses to CBD at a rate of 7-11 % per year. Since the Be-LTT can detect sensitization in workers who have not yet developed a disease it is an important diagnostic tool to detect individuals at risk. In conclusion, the LTT can detect a cell-mediated immunological response of an individual to metals. However, for most metals its usefulness is questionable, with the exception of Be; a positive Be-LTT can identify not only patients with CBD, but also persons at risk of developing CBD in later years.

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“…Food-reactive T cells in PBMCs from patients with food allergy with AD have been shown to proliferate in the presence of food antigens. 8,9 This capacity is, however, not restricted to the patient with food allergy because PBMCs from foodtolerant individuals can also mount significant lymphoproliferative responses when stimulated in vitro. 9 Studies that determined cytokine production in food antigenstimulated PBMCs showed that patients with food allergy have a T H 2-skewed response compared with nonatopic control subjects.…”

mentioning

confidence: 99%

Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow’s milk allergy: Relevance of TH2 cytokines

Schade

Dijk²,

Reijsen³

et al. 2000

Journal of Allergy and Clinical Immunology

101

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Lymphocyte responses to food antigens in patients with atopic dermatitis who are sensitive to foods

Cited by 94 publications

References 15 publications

Lymphocyte Blastogenic Responses to Food Antigens in Cats Showing Clinical Symptoms of Food Hypersensitivity

Lymphocyte Blastogenic Responses to Food Antigens in Cats Showing Clinical Symptoms of Food Hypersensitivity

Diagnostic relevance of the lymphocyte transformation test for sensitization to beryllium and other metals (IUPAC Technical Report)

Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow’s milk allergy: Relevance of TH2 cytokines

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