Lymphocyte Function in the Critically Ill Surgical Patient

McIrvine, Andrew; Mannick, John A.

doi:10.1016/s0039-6109(16)42980-4

Cited by 29 publications

(12 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All three subpopulations of T-lymphocytes decreased in number compared to preoperative level. This response has been previously described [3,7,9] and is in accordance with another of our previous results-the missing influence of early postoperative nutrition on Multitest CMI score (skintest) [12]. The CMI score is used to measure cell-mediated immunity and a decrease in CMI score is seen postoperatively in the same study population with no differences between treatment groups.…”

Section: Discussionsupporting

confidence: 90%

“…The immunological response in patients who received "no food" in the early postoperative period after major surgery has been described [7][8][9], but the conclusions of a trial comparing the postoperative cellular immunological response in patients receiving early postoperative enteral nutrition with that of patients who receive nothing but water in the early postoperative period have, as far as we know, never been published.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial

Beier-Holgersen

Brandstrup

2011

Int J Colorectal Dis

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial

Beier-Holgersen

Brandstrup

2011

Int J Colorectal Dis

View full text Add to dashboard Cite

show abstract

“…In some patients, this leads to a prolonged and severe immune imbalance that is associated with poor prognosis [1][2][3][4]. Four hours after i.v.…”

Section: Introductionmentioning

confidence: 99%

“…Although the innate immune system can respond within hours, the course of ARDS/sepsis frequently exceeds 2-3 weeks. Thus, there is sufficient time for T lymphocytes and other parts of the adaptive immune system to take part in the ongoing immune responses [1,3,6,7].…”

Section: Introductionmentioning

confidence: 99%

Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytes

Vaschetto

Grinstein

Sorbo

et al. 2007

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Human neutrophil peptides (HNP) exert immune-modulating effects. We hypothesized that HNP link innate and adaptive immunity through activation of costimulatory molecules. Human lung epithelial cells and CD4+ lymphocytes were treated with HNP separately or in coculture. Stimulation with HNP induced an increase in cell surface expression of CD54 (ICAM-1), CD80, and CD86 on lung epithelial cells and the corresponding major ligands, CD11a (LFA-1), CD152 (CTLA-4), and CD28 on CD4+ lymphocytes. There was an increased nuclear expression of the transcription factor p53 in human alveolar A549 cells and an elevated NF-kappaB (p50) and a degradation of I-kappaB protein in CD4+ lymphocytes following HNP stimulation. HNP enhanced the interaction between A549 cells and CD4+ lymphocytes by increasing cell adhesion and release of IFN-gamma, IL-2, and IL-8. This was attenuated by using an alpha1-proteinase inhibitor to neutralize HNP. We conclude that HNP play an important role in linking innate to acquired immunity by activation of costimulatory molecules in lung epithelial cells and CD4+ lymphocytes.

show abstract

“…13,23], However, acute bacterial infections are not reported as a cause of lymphopenia. It is gen erally accepted that during the course of an acute infection, granulocytosis indeed modi fies the percentage of peripheral blood lym phocytes (PBL) but not the absolute PBL count.…”

Section: Introductionmentioning

confidence: 99%

Lymphopenia Induced by Acute Bacterial Infections in the Elderly: A Sign of Age-Related Immune Dysfunction of Major Prognostic Significance

Proust

Debouzy

et al. 1985

Gerontology

View full text Add to dashboard Cite

These studies were undertaken to investigate the effect of acute bacterial infections on the absolute number of peripheral blood lymphocytes (PBL) in an elderly population and to evaluate the prognostic significance of a decreased number of PBL in critically ill aged patients. The results show that a significant lymphopenia develops in elderly patients during the course of an acute bacterial infection whereas the same type of acute illness has no effect on the PBL count of younger subjects. The lymphopenia is not related to a particular localization of the infection nor to the type of bacterial pathogen. The prognosis of the bacterial infection is closely linked to the severity of the lymphocyte depletion and its outcome can nearly be predicted by monitoring the variation of the number of circulating lymphocytes during the early course of the disease.

show abstract

Lymphocyte Function in the Critically Ill Surgical Patient

Cited by 29 publications

References 69 publications

Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial

Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial

Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytes

Lymphopenia Induced by Acute Bacterial Infections in the Elderly: A Sign of Age-Related Immune Dysfunction of Major Prognostic Significance

Contact Info

Product

Resources

About