Lymphocyte Function and Abdominal Operations

Feliciano, David V.; Gorman, R. O; Bitondo, Carmel G.; Cruse, Pamela A.; Matthews, R.; Matthews, Kathleen S.

doi:10.1097/00132586-198804000-00010

Cited by 2 publications

(2 citation statements)

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“…Surgical patients with abdominal trauma or burns have diminished numbers of circulating T lymphocytes, especially those of helper T lymphocytes, when developing sepsis. 28,29 Reversal of the normal T-helper to T-suppressor cell ratio predicted sepsis after a major injury. 29 Polyclonal activation of immunoglobulin production, however, continued unhindered in similar cases.…”

Section: Cell-mediated Immune Responsesmentioning

confidence: 99%

Autoimmune Factors in Endometriosis: Cause or Effect?

Homm¹,

Mathur²

1988

Semin Reprod Med

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Section: Cell-mediated Immune Responsesmentioning

confidence: 99%

Autoimmune Factors in Endometriosis: Cause or Effect?

Homm¹,

Mathur²

1988

Semin Reprod Med

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“…A number of in vitro techniques, such as the stimulation of lymphocytes by the T-cell mitogens phytohaemagglutinin-A (PHA) and concanavalin-A, have also been widely used, showing that the immune system is influenced by trauma; the responsiveness of lymphocytes to mitogens becomes impaired and this change is related to the degree of the trauma [2,4,51. Also, the technique of anaesthesia might be of importance in patients undergoing surgery, since halothane and epidural anaesthesia, which both block the sympatho-adrenal response to surgical stress more effectively than conventional neurolept anaesthesia, also influence lymphocyte reactivity less than neurolept anaesthesia [&lo].…”

Section: Introductionmentioning

confidence: 99%

Determination of Protein Synthesis in Lymphocytes in Vivo after Surgery

Essén¹,

McNurlan²,

Thorell

et al. 1996

Clinical Science

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1. The stimulation and depression of peripheral blood lymphocytes has previously been studied in vitro, showing an immune depression postoperatively; however, it is difficult to interpret these in vitro findings. Therefore, an in vivo technique has been established for determination of the fractional protein synthesis rate, as an index of metabolic activity in human peripheral blood lymphocytes, by using a stable isotope technique. 2. The rate of protein synthesis was calculated from the increase in enrichment of L-[2H5]phenylalanine in protein of a mixed population of mononuclear leucocytes, isolated by density gradient, after an intravenous flooding dose of L-[2H5]phenylalanine. A linear time course of isotopic incorporation into the cells was demonstrated. 3. The fractional rate of protein synthesis of a mixed population of mononuclear leucocytes was studied in relation to surgical interventions and to potential modifiers of the response. The fractional synthesis rate increased 24 h after open and laparoscopic cholecystectomy (49 +/- 19% and 40 +/- 14% respectively, P < 0.02), irrespective of postoperative total parenteral nutrition or preoperative glucose infusion. In contrast to surgery, insulin did not stimulate protein synthesis in peripheral mononuclear leucocytes.

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Lymphocyte Function and Abdominal Operations

Cited by 2 publications

References 0 publications

Autoimmune Factors in Endometriosis: Cause or Effect?

Autoimmune Factors in Endometriosis: Cause or Effect?

Determination of Protein Synthesis in Lymphocytes in Vivo after Surgery

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