Lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

“…Conversely, a lower lymphocyte count was reported in ESRD patients and was shown as a predictor of morbidity and mortality in this population . Our early study indicates lymphocyte subset alteration occurs at early stage of CKD patients . More in‐depth analyses of changes in lymphoid cells reveal reduced numbers of naïve T and B cells, increased T cell differentiation, and loss of telomere length in ESRD patients, which resemble changes in immunological ageing .…”

“…30,51 Our early study indicates lymphocyte subset alteration occurs at early stage of CKD patients. 52 More in-depth analyses of changes in lymphoid cells reveal reduced numbers of na€ ıve T and B cells, increased T cell differentiation, and loss of telomere length in ESRD patients, which resemble changes in immunological ageing. 53,54 Further studies reveal expansion of a unique pro-inflammatory, cytotoxic subset of CD4 1 CD28null T cells is associated with atherosclerotic damage in this population.…”

Efeitos do uso de globulina antitimócito e de everolimo nas subpopulações de linfócitos T e B do sangue periférico em receptores idosos de transplante renal

“…End stage renal disease (ESRD) also induces phenotype and functional changes in peripheral lymphocytes. Although most studies agree that a T-cell lymphopenia accompanies the progressive loss of renal function [14][15][16], the numbers of naive T-cells have been reported to be reduced [17,18] or unchanged [16] among ESRD. There is also no agreement regarding the frequencies of memory T-cells among uremic patients.…”

“…As diferenças observadas foram consideradas estatisticamente significativas quando o teste de comparação empregado apresentasse p<0,05. ------24 (22,6) 25 (22,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)2) 0,206…”

“…Vale relembrar que nos últimos anos houve importante mudança na caracterização fenotípica dos linfócitos T reguladores, com a descrição da proteína FoxP3(HORI;, descrição da baixa expressão ou ausência de expressão de CD127(LIU;, além da descrição de novos marcadores, como CD39 para população TREG de maior atividade(DWYER;. Os vários estudos são heterogêneos em suas definições, dificultando comparações acuradas.Os achados deste estudo em linfócitos B na doença renal crônica convergem com a literatura descrevendo menores números absolutos de linfócitos B totais(FERNÁNDEZ-FRESNEDO; e menores percentuais(FERNÁNDEZ-FRESNEDO; com percentuais de linfócitos B naive e BREG mantidos.…”