Lymphocyte Cyclic Nucleotide and Prostaglandin Content in Psoriasis: A Preliminary Report

S, Harpaz

doi:10.1001/archderm.1980.01640280063020

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…However, Geerdink et al (1980) investigated mononuclear leukocjrtes containing only 30% monoc)rtes. The decreased cAMP level was therefore possibly confined to the contaminating lymphocytes as reported by others (Harpaz et al, 1980). A potent chemotactic activity for peripheral blood leukocytes has been shown in psoriatic scales (Tagami & Ofuji, 1976), possibly a C5 cleavage product.…”

Section: Discussionsupporting

confidence: 64%

Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Herlin

Kragballe

1981

British Journal of Dermatology

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Eighteen patients with active psoriasis were investigated for antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by monocytes and neutrophil leukocytes. Patients with extensive psoriatic lesions showed increased ADCC whereas patients with minimal psoriasis had normal monocyte and neutrophil function. After clinical remission the ADCC became normal. No stimulatory factors in psoriatic serum could be demonstrated. The increased monocyte and neutrophil cytotoxicity in severe psoriasis is not explained by altered cyclic nucleotide levels as cAMP and cGMP levels were normal in psoriatic monocytes and neutrophils showing both increased and normal ADCC. Our results indicate that increased ADCC is secondary to the psoriatic activity.

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Section: Discussionsupporting

confidence: 64%

Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Herlin

Kragballe

1981

British Journal of Dermatology

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Mononuclear Leukocyte Cyclic Adenosine Monophosphate Responses in Psoriasis Are Normal

Archer

Hanson²,

Morley³

et al. 1984

Journal of Investigative Dermatology

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It has been proposed that immune dysfunction in psoriasis is a consequence of aberrant cyclic nucleotide metabolism. We have examined cyclic AMP responses to isoprenaline, histamine, and prostaglandin E2 in peripheral blood mononuclear leukocytes from patients with psoriasis, in the presence and absence of a potent cyclic AMP phosphodiesterase inhibitor. Stimulated and basal cyclic AMP levels in mononuclear leukocytes from psoriatics did not differ from those observed in mononuclear leukocytes from normal subjects, irrespective of the stimulant employed, either in the presence or in the absence of the phosphodiesterase inhibitor. These findings do not support the hypothesis that psoriasis is associated with either impaired beta-adrenergic reactivity or a more generalized abnormality of mononuclear leukocyte cyclic nucleotide metabolism.

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Lymphocyte Cyclic Nucleotide and Prostaglandin Content in Psoriasis: A Preliminary Report

Cited by 2 publications

References 19 publications

Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Mononuclear Leukocyte Cyclic Adenosine Monophosphate Responses in Psoriasis Are Normal

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