Lymphocyte‐C‐reactive protein ratio as a novel prognostic index in intrahepatic cholangiocarcinoma: A multicentre cohort study

Abstract

Background & Aims The lymphocyte‐C‐reactive protein ratio (LCR) is a novel inflammatory‐based score, based solely on the lymphocyte and C‐reactive protein. We aimed to clarify the prognostic value of the LCR score in intrahepatic cholangiocarcinoma (ICC) patients after resection. Methods We compared the prognostic accuracy of the LCR score with other inflammatory‐based scores in this large, multicentre cohort study. The independent variables associated with overall survival (OS) were explored in both the primary (n = 228) and validation cohorts (n = 135). Harrell's concordance index (C‐index) was used to compare the predictive ability of all the assessed inflammatory‐based scores. Results The LCR score was differentiated two groups of ICC patients with distinct prognoses (1‐, 3‐, and 5‐year OS rates: 94.4%, 66.3%, and 59.3%; and 66.6%, 45.6%, and 32.7%, respectively) (P < .001). Multivariate analysis showed that the LCR score, as well as the TNM stage and preoperative CA19‐9 level, were independently associated with OS. The predictive accuracy of the LCR score (c score: 0.634) was superior to that of the other inflammatory‐based scores (c scores: 0.508‐0.615). These findings were supported by the external validation cohort. Conclusion The LCR score is stable and consistently the best prognostic score and may offer as a simple, objective and discriminatory method in facilitating the risk stratification of ICC patients.

LDH-to-leukocyte ratio predicts COVID-19 diagnosis and CRP-to-lymphocyte ratio predicts prognosis of patients with COVID-19

“…Interestingly, the lymphocyte-to-C-reactive protein ratio (i.e. ALC/CRP ratio, the reciprocal of CRP/ALC ratio) has been described as marker of in ammation and outcome in patients with different gastrointestinal cancers [21], [22] and as marker for intestinal ischemia in strangulated abdominal wall hernias [23] recently, but not in COVID-19 or other infectious diseases.…”

The tireless search to improve the prognostic assessment of intrahepatic cholangiocarcinoma: An urgent need

“…In this issue of Liver International , Lu et al explored the lymphocyte‐C‐reactive protein ratio (LCR) score as a prognostic value after resection in iCCA 10 . They included two large cohorts of iCCA patients (study cohort, n = 228 and validation cohort, n = 135) from two referral centres in China.…”

Prognostic Significance of Preoperative Lymphocyte-to-C-Reactive Protein Ratio in Patients with Non-Metastatic Colorectal Cancer

“…9,10 Recently, another alternative composite inflammatory index, lymphocyte-to-C-reactive protein (LCR), represented as a combination of circulating lymphocyte and C-reactive protein counts, has been gained notable attention as a prognostic factor in gastric cancer, rectal cancer, and cholangiocarcinoma. [11][12][13] However, the prognostic potential of LCR has not been explored for patients with non-metastatic CRC. Moreover, it remains unclear which combination of inflammatory markers might be best in predicting survival outcome in patients with CRC.…”